MENU
SEP 09, 2019 8:00 AM PDT

Challenges in hemostasis test standardization

Sponsored by: Diagnostica Stago, Inc.
Speaker
  • Medical Director, UHS Pathology Services, University Health System; Professor, Clinical Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio
    BIOGRAPHY

Abstract

Standardization and harmonization of coagulation testing methods have come a long way in the last 3 to 4 decades; however, standardization is imperfect.  Laboratory professionals need to recognize the limitations of some of our most commonly used coagulation tests.  The INR system has harmonized prothrombin time across methods and platforms for the purpose of monitoring warfarin, but the system does not harmonize very high INR values nor does it harmonize INR values in the setting of liver disease.  Many hospital-based laboratories perform a one stage factor VIII assay to support a wide range of clinical indications.  In the last decade, important biases have been demonstrated between one stage assays and chromogenic assays when diagnosing hemophilia A patients or monitoring new hemophilia therapies.  Finally, quantitative D-dimer assays have excellent negative predictive value to exclude venous thromboembolism.  Unfortunately, there is a lack of standardization, and even a lack of a standardized unit of measure.  Implementation of D-dimer requires careful attention to both the unit of magnitude and the unit type, especially when using different instrumentation across a laboratory system.

Learning Objectives:

  • Recognize limitations of INR system
  • Choose appropriate factor VIII and factor IX assays for various clinical indications
  • Identify potential safety issues created by nonuniform D-dimer units and lack of standardization

 

 

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.  CE credits are available for this webinar up to 2 years from the date of the live broadcast


Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
APR 21, 2021 10:00 AM PDT
C.E. CREDITS
APR 21, 2021 10:00 AM PDT
Date: April 21, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Serological testing for SARS-CoV-2 has been steadily adopted into clinical practice over the course of this pandemic. In this webinar,...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
MAY 18, 2021 8:00 AM PDT
C.E. CREDITS
MAY 18, 2021 8:00 AM PDT
Date: May 18, 2021 Time: 8:00am (PST) The global pandemic has caused an increased focus and scrutiny on molecular diagnostic assay development, resulting in a need for assays that provide qu...
APR 08, 2021 11:00 AM PDT
C.E. CREDITS
APR 08, 2021 11:00 AM PDT
Date: April 8, 2021 Time: 11:00am (PDT), 3:00pm (EDT) Pneumonia is a deadly condition with clinical outcomes highly dependent on prompt and appropriate therapy. Diagnosis of pneumonia is cha...
SEP 09, 2019 8:00 AM PDT

Challenges in hemostasis test standardization

Sponsored by: Diagnostica Stago, Inc.

Specialty

Laboratory Testing

Immunology

Clinical Diagnostics

Microbiology

Clinical Chemistry

Hematology

Infectious Disease

Molecular Diagnostics

Molecular Biology

Biochemistry

Cell Biology

Genetics

Diagnostics

Biotechnology

Clinical Research

Geography

North America79%

Asia10%

Europe7%

Africa2%

South America1%

Oceania1%

Registration Source

Website Visitors58%

Email Promotions30%

WAVE Newsletter Promotion8%

Client/Sponsor Promotions1%

Trending Newsletter Promotion1%

Other1%

Job Title

Medical Laboratory Technician30%

Clinical Laboratory Scientist19%

Lab Management13%

Medical Doctor/Specialist7%

Facility/Department Manager7%

Educator/Faculty4%

Student4%

Research Scientist3%

QC/QA3%

Executive3%

Scientist2%

Pathologist2%

Marketing/Sales1%

Biologist1%

Chemist1%

Organization

Hospital39%

Clinical Laboratory18%

Academic Institution10%

Medical Center5%

Government2%

Biotech Company2%

Independent Laboratories2%

Medical Device Company2%

Diagnostic Company2%

Medical School1%

Ambulatory Care1%

Consultant1%

Research Institute1%

Non-Profit Organization1%

Other3%


Show Resources
Loading Comments...
Show Resources