SEP 28, 2017 10:30 AM PDT

Engineering stem cell biology for disease modelling and therapeutics

Presented at: Cell Biology 2017
Speaker
  • Postdoctoral Associate, University of Wisconsin-Madison
    Biography
      Amr Abdeen received his Bachelors of Science from the German University in Cairo at 2010 in materials science and engineering. He pursued his PhD in materials science under the supervision of prof. Kristopher Kilian at the University of Illinois at Urbana-Champaign, where he studied biomaterials for the control of adult stem cells. His thesis focused on controlling mesenchymal stem cell angiogenic potential via biomaterials methods. He joined the Wisconsin Institute for Discovery in 2016, where his current work focuses on CRISPR based gene editing in multiple cell types, including pluripotent stem cells.

    Abstract

    Stem cells can self-renew and differentiate into multiple different cell types. Engineering of stem cells has enabled new methods to study development and organogenesis in humans as well as develop new disease models and therapies. Stem cells can be obtained from multiple sources in vivo or generated in the lab. Engineering of pluripotent stem cells, for example, can potentially generate any tissue in the body and can be used for tissue repair or organoid formation. Furthermore, advances in gene editing technologies have enabled precise editing of stem cell genomes, creating possibilities for establishment of models for diseases and personalized therapies. In this lecture I will discuss the sources and properties of various stem cells as well as their utilization in modelling, therapy and tissue engineering. 


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