SEP 24, 2014 12:00 PM PDT

Exploiting cell death for drug discovery

  • Professor, Columbia University, Departments of Biological Sciences and Chemistry
      A decorated researcher, Stockwell is investigating mechanisms of cell death and exploring their application in the treatment of cancer and neurodegeneration. His investigations have not only identified drug candidates, they've inspired new methods of small molecule drug discovery. Stockwell is author of The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines.

    Professor Stockwell will discuss the discovery of ferroptosis, a novel model of regulated but non-apoptotic cell death. He will describe how some tumors are sensitized to ferroptosis and may be targeted with compounds that inhibit cystine-glutamate exchange or the lipid repair enzyme Gpx4, leading to ferroptotic cell death. In addition, he will discuss small molecule inhibitors of ferroptosis, and how such compounds have been used to implicate activation of ferroptosis in numerous degenerative diseases.

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