JUN 20, 2018 09:00 AM PDT

Identifying Driver Alterations and Therapeutic Options in Cancer

C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Head of Knowledge Systems, Marie-Josée & Henry R. Kravis Center for Molecular Oncology
    Biography
      Nikolaus Schultz leads the development of the cBioPortal for Cancer Genomics, a popular resource for the visualization and analysis of large-scale cancer genomics data sets. His research focuses on identifying the genomic alterations that underlie different types of cancer. He is involved in several projects of The Cancer Genome Atlas (TCGA) and is an investigator in the Stand Up To Cancer (SU2C) Prostate Cancer Dream Team.

      Dr. Schultz is an Associate Attending Computational Oncologist in the Department of Epidemiology and Biostatistics and an affiliate member of the Human Oncology and Pathogenesis Program. He is the Head of Knowledge Systems in the Marie-Josée and Henry R. Kravis Center for Molecular Oncology.

    Abstract:

    With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for clinical support tools that aid clinicians in their decision making. To this end, we are developing tools for the visualization and interpretation of genomic variants in the context of clinical annotation. 

    To this end, we have developed OncoKB, a precision oncology knowledge base that annotates the effects and treatment implications of somatic mutations in cancer. OncoKB annotations are available for research use via oncokb.org, and the database is used to annotate the sequencing reports of of tumor samples from patients at Memorial Sloan Kettering Cancer Center. 

    We are also co-developers of the cBioPortal for Cancer Genomics. The cBioPortal is an open source software tool that provides intuitive visualization and analysis of cancer genomics data, allowing cross-cohort analyses but also the viewing and interpretation of individual tumor samples. The public site at cbioportal.org provides access to published sequencing data from more than 25,000 tumor samples, and private instances of cBioPortal are installed at multiple academic research centers, in hospitals, and pharmaceutical companies. Annotations from OncoKB as well as other sources, such as COSMIC, CIViC, and cancerhotspots.org, are integrated into cBioPortal to facilitate the interpretation of variants in cancer cohorts and individual patient samples.

    This presentation will summarize the challenges of precision oncology and cancer genomics research and will present how OncoKB and the cBioPortal for Cancer Genomics can be used to overcome some of these challenges.


    Show Resources
    You May Also Like
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    MAY 16, 2019 04:00 PM CEST
    C.E. CREDITS
    MAY 16, 2019 04:00 PM CEST
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    NOV 18, 2019 07:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    NOV 18, 2019 07:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    Loading Comments...
    Show Resources