MAR 13, 2019 8:20 AM PDT

BRAIN Initiative Scientific Updates: Influence of Task Context on Motor Cortical Activity During Reaching and Grasping

Presented at: Neuroscience 2019
Speaker
  • Assistant Professor, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Rehab Neural Engineering Labs, Biomedical Engineer, VA R&D Center of Excellence
    BIOGRAPHY

Abstract

Humans interact with their environment in countless ways and can switch seamlessly between activities. Even for seemingly simple tasks, a variety of sensory inputs and contextual cues are integrated to create a motor plan to complete a task. In our work, we manipulate aspects of task context to study sensorimotor processing during grasping and object exploration tasks. Our experiments are conducted as part of an ongoing effort to develop intracortical-brain computer interface (BCI) devices for people with paralysis. This experimental paradigm allows us to study sensorimotor processing during complex tasks, which will ultimately lead to the development of improved neuroprosthetics. Study participants use the BCI to control a robotic arm and hand, which allows us to precisely control the mapping between neural activity and movement as well as the somatosensory inputs. Previous work supports the idea that neural activity generated during attempted movements in people with spinal cord injury exhibits the same relationship to movement variables as an able-bodied subject. Similarly, stimulation of somatosensory cortex in a person with chronic tetraplegia generates localized sensations that follow the expected spatial organization.

I will provide an overview of our approach to controlling a motor BCI, which is based on an understanding of motor cortical activity measured in non-human primates during overt reaching and grasping behavior. I will also discuss a primary motivation for our current work that is investigating the influence of task context on motor control. We observed that that motor cortical activity is fundamentally different when reaching to and grasping an object, versus reaching with identical kinematics in an empty workspace. In more recent experiments, we have focused on the motor control of grasping.  We have observed encoding of implicit grasp force representations associated with familiar objects at particular phases of object grasping and transport movements. Additionally, even when explicit force targets are instructed, we see transient periods of motor cortical activity that are most informative about grasp force control. Overall, our experiments have shown the motor cortical activity is dependent on the context of a task and is not simply communicating a task-invariant motor plan to the upper limb.  


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
JUL 15, 2021 9:00 AM PDT
JUL 15, 2021 9:00 AM PDT
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
SEP 29, 2021 11:00 AM PDT
C.E. CREDITS
SEP 29, 2021 11:00 AM PDT
Date: Septembr 29, 2021 Time: 11:00am (PDT), 2:00pm (EDT) 3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. While...
OCT 27, 2021 6:00 AM PDT
C.E. CREDITS
OCT 27, 2021 6:00 AM PDT
Date: October 27, 2021 Time: 6:00 AM PDT, 9:00 AM EDT Etanercept is a recombinant Fc fusion protein therapeutic that has a complex distribution of post-translation modifications (PTM), such...
MAR 13, 2019 8:20 AM PDT

BRAIN Initiative Scientific Updates: Influence of Task Context on Motor Cortical Activity During Reaching and Grasping

Presented at: Neuroscience 2019

Specialty

Biochemistry

Laboratory Testing

Bioinformatics

Brain

Biomedical Engineering

Immunology

Geography

Africa50%

Registration Source

Website Visitors100%

Job Title

Biologist50%

Post Doc50%

Organization

Clinical Laboratory50%

Other50%


Show Resources
Loading Comments...
Show Resources