MAR 13, 2019 8:20 AM PDT

BRAIN Initiative Scientific Updates: Influence of Task Context on Motor Cortical Activity During Reaching and Grasping

Presented at: Neuroscience 2019
Speaker
  • Assistant Professor, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Rehab Neural Engineering Labs, Biomedical Engineer, VA R&D Center of Excellence
    Biography
      Jennifer Collinger is an Assistant Professor in the Department of Physical Medicine and Rehabilitation at the University of Pittsburgh and a Research Biomedical Engineer at the VA R&D Center of Excellence. Dr. Collinger's research interests are related to the use of neuroprosthetics and neurorehabilitation to restore function for individuals with upper limb paralysis or loss. In order to do so, her research program focuses on understanding the motor control of upper limb movements in both able-bodied participants and people with motor impairments. Currently, she is part of a team that is developing intracortical brain-computer interface technology for individuals with tetraplegia. This provides a unique opportunity to study sensorimotor cortical activity during complex motor behaviors.

    Abstract

    Humans interact with their environment in countless ways and can switch seamlessly between activities. Even for seemingly simple tasks, a variety of sensory inputs and contextual cues are integrated to create a motor plan to complete a task. In our work, we manipulate aspects of task context to study sensorimotor processing during grasping and object exploration tasks. Our experiments are conducted as part of an ongoing effort to develop intracortical-brain computer interface (BCI) devices for people with paralysis. This experimental paradigm allows us to study sensorimotor processing during complex tasks, which will ultimately lead to the development of improved neuroprosthetics. Study participants use the BCI to control a robotic arm and hand, which allows us to precisely control the mapping between neural activity and movement as well as the somatosensory inputs. Previous work supports the idea that neural activity generated during attempted movements in people with spinal cord injury exhibits the same relationship to movement variables as an able-bodied subject. Similarly, stimulation of somatosensory cortex in a person with chronic tetraplegia generates localized sensations that follow the expected spatial organization.

    I will provide an overview of our approach to controlling a motor BCI, which is based on an understanding of motor cortical activity measured in non-human primates during overt reaching and grasping behavior. I will also discuss a primary motivation for our current work that is investigating the influence of task context on motor control. We observed that that motor cortical activity is fundamentally different when reaching to and grasping an object, versus reaching with identical kinematics in an empty workspace. In more recent experiments, we have focused on the motor control of grasping.  We have observed encoding of implicit grasp force representations associated with familiar objects at particular phases of object grasping and transport movements. Additionally, even when explicit force targets are instructed, we see transient periods of motor cortical activity that are most informative about grasp force control. Overall, our experiments have shown the motor cortical activity is dependent on the context of a task and is not simply communicating a task-invariant motor plan to the upper limb.  


    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    DEC 16, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 16, 2020 8:00 AM PST
    Date: December 16, 2020 Time: 8:00am (PST), 11:00am (EST) Molecular imaging of living specimens offers a means to draw upon the growing body of high-throughput molecular data to better under...
    APR 01, 2021 8:00 AM PDT
    C.E. CREDITS
    APR 01, 2021 8:00 AM PDT
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    MAR 13, 2019 8:20 AM PDT

    BRAIN Initiative Scientific Updates: Influence of Task Context on Motor Cortical Activity During Reaching and Grasping

    Presented at: Neuroscience 2019

    Specialty

    Biochemistry

    Laboratory Testing

    Bioinformatics

    Brain

    Biomedical Engineering

    Immunology

    Geography

    Africa50%

    Registration Source

    Website Visitors100%

    Job Title

    Biologist50%

    Post Doc50%

    Organization

    Clinical Laboratory50%

    Other50%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more