His work has been supported by grants from National Science Foundation, National Institute of Health and Kentucky Science Foundation. The main research projects are:
1. Development of the Tomato bushy stunt virus (TBSV)-yeast system to study virus replication and virus-host interactions. His lab has developed the TBSV-yeast system because of the advantages of using yeast as a model host. 2. Genome-wide screens and global proteomics approaches to identify host factors affecting TBSV replication. His lab have performed a dozen complementary genome-wide and global proteomics approaches that have led to the identification of ~500 host genes affecting TBSV replication in yeast. 3. Characterization of co-opted host factors critical for TBSV replication. 4. Discovery of cell-intrinsic restriction factors against TBSV replication.
Dr. Nagy published 150 scientific papers and got numerous awards for his scientific work, including Science and Engineering Award from the Governor of Kentucky (2002), Faculty Futures Award, University of Kentucky (2004), Bobby Pass Excellence in Grantsmanship Award (2006 and 2013), Thomas P. Cooper Research Award (2007), University Research Professor Award (2007), Ruth Allen Research Award, Phytopathology Society (2008), and prestigious paper award, University of Kentucky (2016).