MAY 13, 2015 03:00 PM PDT
Journeys through Space and Time: Ultra High-Resolution Expression Profiling of Long Noncoding RNAs
Presented at the Genetics and Genomics Virtual Event
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  • Head of Clinical Genomics, Garvan Institute of Medical Research, Conjoint Associate Professor at the University of New South Wales
      Marcel Dinger is the Head of Genome Informatics at the Garvan Institute of Medical Research and conjoint Associate Professor at UNSW Australia. After completing his PhD at the University of Waikato (New Zealand), he was awarded a NZ FoRST Postdoctoral Fellowship to join Professor Mattick's group at The University of Queensland to study the role of long noncoding RNAs in mammalian development and disease. He was recruited to the Garvan Institute in 2012.

    Long noncoding RNAs (lncRNAs) are increasingly recognized as having key regulatory roles in development and disease. However, these regulatory molecules often have short half lives and are expressed only in specific tissues or cell types, resulting in the poor representation of lncRNAs in transcriptomic datasets. Using novel detection and sampling approaches, we reveal a high-resolution spatiotemportal view of the long noncoding transcriptome that provides fresh insights into their roles in development and disease. Learning Objectives: 1. Provide an example of how a technology advancement has led to a key change in our understanding of the functions of the genome. 2. Explain the effect of increased cellular diversity on transcriptome coverage attained by RNA sequencing. 3. Describe the different ways that regulatory information can be stored in noncoding regions of the genome.

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