MAY 30, 2018 7:30 AM PDT

Keynote Presentation: Robotic Automation of Human Cell Culture for Regenerative and Reparative Medicine

Presented at: Lab Automation 2018
Speaker
  • Professor and Associate Director of Clinical Chemistry and Toxicology, Univerisity of Virgina School of Medicine
    Biography
      Dr. Robin Felder is a Professor of Pathology and Associate Director of Laboratory Medicine at the University of Virginia-UVA, and is Chair of Medical Automation.org. Dr. Felder received his PhD in Biochemistry from Georgetown University. He has published over 300 papers, reviews, and chapters, and co-edited 3 textbooks on medical automation. He has been awarded 27 patents and has founded 9 biotech companies, including 2 non-profit organizations including the Association for Laboratory Automation (SLAS) (and its journal JALA) as well as Medical Automation.org. He has received numerous awards including the Engelberger Robotics Award, UVA's Innovator of the Year Award, and the Annual Research Awards from the American Association for Clinical Chemistry (AACC), and National Academy for Clinical Biochemistry (NACB).

    Abstract

    Growing living human cells in vitro for basic research, drug discovery and reparative/regenerative medicine is challenged by the difficulty in developing methods for reproducibly and cost effectively growing large number of human cells in a way that represents in vivo cellular environment.  3D cell culture is a discipline that will ultimately replace 2D cell culture (culture performed on flat plastic surfaces) since the use of biologically relevant surfaces, substances, geometries, and stresses produces cells which more reliably express their in vivo phenotypes and physiology (PMIDs 12931155; 24912145).  Automation and robotics will be necessary to provide parallel and/or random access processing of many cell lines simultaneously so that they will better represent human physiology and meet the FDA’s evolving “good laboratory practice” (GLP) and “good manufacturing practice” (GMP) standards under development for cultured cells.  Automation and robotics will be developed in conjunction with new cell culture methods including the use of 3D technologies incorporating biomimetic substrates, xeno-free cell culture media, shear forces, and oxygen concentrations that more closely mimics the in vivo environment. The inherent design of our fully automated next generation 3D cell culture system will virtually eliminate cell misidentification, contamination and infection, while optimizing cell growth and phenotype in order to provide many industries, including the reparative/regenerative medical industries with the highest quality products.


    Learning Objectives: 

    1.  You will learn the advantages of automated 3D cell culture over conventional cell culture methods.
    2.  What kinds of control systems will be employed to enable a robot to perform the complex and demanding tasks associated with human cell culture.


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