Dr. Melissa Smith is an Assistant Professor of Biochemistry and Molecular Genetics at the University of Louisville. She joined the faculty there in July of this year, after spending the prior four years managing the Genomics Technology Core team at the Icahn School of Medicine at Mount Sinai. Dr. Smith's personal research focuses on utilizing cutting edge genomics technologies to investigate host-pathogen interactions. Specifically, she has been using single molecule, real-time (SMRT) sequencing methods to define mechanisms of viral immune evasion and profile host immune repertoires for more than six years. Ongoing work in her laboratory utilizes the long, phased reads provided by SMRT sequencing to reconstruct and profile the incredibly complex immune loci in the human genome (HLA, Ig, TCR) as well as viral surveillance and evolution, including SARS-CoV2 and HIV.