OCT 03, 2018 9:00 AM PDT

Mechanisms of Myeloid Immunosuppression: Functional Characterization of the Tumor Microenvironment Using Single and Multiplex IHC

Speaker
  • IHC Specialist, Cell Signaling Technology
    Biography
      Chris has close to ten years of experience working with a variety of immunohistochemical techniques and technologies. His main focus over this time has been development and validation of IHC grade antibodies in a number of research areas. This has required a deep understanding of not only the IHC assay itself but also expression profiles of the human proteome in normal and diseased tissues. The main area of focus has been immuno-oncology, where Chris has developed automated IHC assays for novel I/O targets and provided support for multiple pre-clinical programs. His experience also includes design and development of multiplex immunofluorescent IHC assay panels and implementation of IHC digital quantitation software.

    Abstract
    DATE: October 3, 2018
    TIME:  9:00am PDT, 12:00pm EDT
     
    Infiltrating myeloid cells constitute a significant component of the suppressive tumor microenvironment (TME) and possibly contribute to therapeutic failures. An understanding of the immune regulatory context of the TME is required to harness the power of the antitumor immune response. Here, we present solutions to better understand the TME in a context-dependent manner. Using highly validated antibodies, immunohistochemical techniques are employed in a seven-color TSA-based multiplex panel along with single and dual-plex chromogenic stains to visualize biomarker expression in an array of tumor types. Newly validated Arginase1 and IDO1 monoclonal antibodies add a functional readout of the immunosuppressive TME to phenotypic marker analysis.
     
    Learning Objectives:
    • Understand the importance of the immune regulatory context of the TME
    • Learn about solutions to better understand the TME in a context-dependent manner

    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    DEC 15, 2020 10:00 AM PST
    C.E. CREDITS
    DEC 15, 2020 10:00 AM PST
    DATE: December 15, 2020 TIME: 10:00am PST Scientists from Thermo Fisher Scientific will walk us through the world of microorganisms. They will discuss their most recent research on viruses,...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    APR 01, 2021 8:00 AM PDT
    C.E. CREDITS
    APR 01, 2021 8:00 AM PDT
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    OCT 03, 2018 9:00 AM PDT

    Mechanisms of Myeloid Immunosuppression: Functional Characterization of the Tumor Microenvironment Using Single and Multiplex IHC


    Specialty

    Cancer Research

    Immunology

    Cancer Therapeutics

    Cell Biology

    Cancer Diagnostics

    Immuno-Oncology

    Molecular Biology

    Biomarkers

    Oncology

    Biotechnology

    Antibodies

    Biochemistry

    Cell Culture

    Clinical Research

    Cell Signaling / Transduction

    Geography

    North America53%

    Europe26%

    Asia10%

    Africa5%

    South America4%

    Oceania2%

    Registration Source

    Website Visitors73%

    Email Promotions13%

    WAVE Newsletter Promotion10%

    Website Banners2%

    Social Media Promotions1%

    Trending Newsletter Promotion1%

    Other1%

    Job Title

    Student19%

    Research Scientist18%

    Scientist14%

    Executive9%

    Educator/Faculty8%

    Medical Laboratory Technician7%

    Post Doc7%

    Facility/Department Manager6%

    Medical Doctor/Specialist5%

    Lab Management3%

    Clinical Laboratory Scientist2%

    Biologist1%

    Organization

    Academic Institution21%

    Biotech Company13%

    Research Institute12%

    Hospital10%

    Pharmaceutical Company7%

    Clinical Laboratory7%

    Medical School6%

    Medical Center5%

    Government4%

    Life Science Company3%

    Non-Profit Organization2%

    Industrial Company2%

    Contract Research Organization (Cro)1%

    Ambulatory Care1%

    Other3%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more