MAR 28, 2019 10:30 AM PDT

Medical Cannabis Pharmacogenomics and Drug Interactions

Speaker

Abstract

The therapeutic applications of medical cannabis and cannabinoid drugs is controversial, however the number of medical conditions in which cannabinoids and cannabis have shown promise as therapeutic treatments is expanding. The occurrence of side effects from cannabinoids is still a concern, especially with the wide variability in drug levels and response that has been observed. This is compounded by possible interactions with prescription drugs. Application of pharmacogenomics (PGx) and knowledge of drug-drug interactions could help patients and doctors navigate the complexities of combining prescription drugs and cannabis compounds. Genetic variants in several drug metabolizing enzymes may impact response to cannabinoids, including CYP3A4, CYP2C9, and CYP2C19. Furthermore, drug interactions caused by cannabinoids may also be mediated by drug metabolizing enzymes (e.g. CYP2C9, CYP2D6, CYP2B6, CYP1A1) and possibly drug transporters such as ABCB1. Understanding how commonly prescribed drugs and cannabinoids interact could help reduce risks associated with polydrug regimens. This presentation will discuss PGx testing for cannabis and potential impacts on commonly prescribed pharmaceuticals.

 

Learning Objectives: 

1. Be able to discuss CYPs involved with cannabinoid metabolism 
2. Know potential risks associated with oral CBD administration


Show Resources
You May Also Like
MAR 16, 2022 8:00 AM PDT
C.E. CREDITS
MAR 16, 2022 8:00 AM PDT
Date: March 16, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CET) Handling of potent and/or hazardous substances is commonplace in sev.....
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
MAR 09, 2022 9:00 AM PST
C.E. CREDITS
MAR 09, 2022 9:00 AM PST
Date: March 9, 2022 Time: 9:00am (PST), 12:00pm (EST) For laboratories that operate within a quality management system, purchasing the correct freezer is business critical. While some may th...
AUG 17, 2022 10:00 AM PDT
AUG 17, 2022 10:00 AM PDT
DATE: October 22, 2020 TIME: 8:00am PDT, 11:00am EDT Detection and/or amplification of target DNA sequences by polymerase chain reaction (PCR) is a prevalent method in molecular biology. PCR...
MAR 16, 2022 9:00 AM PDT
C.E. CREDITS
MAR 16, 2022 9:00 AM PDT
Date: March 16, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEDT) With a renewed and growing interest in therapeutic oligonucleotides (oligos) across the pharmaceutical industry, the req...
C.E. CREDITS
In-house testing is not required federally; however, states differ in their requirements. Cannabis extraction laboratories need to test extracts for pesticides, heavy metals, residual solven...
MAR 28, 2019 10:30 AM PDT

Medical Cannabis Pharmacogenomics and Drug Interactions



Show Resources
Loading Comments...
Show Resources