APR 26, 2022 7:00 AM PDT

Modelling of cellular interactions in mixed murine organoids

Sponsored by: Andor
C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract
Date:  April 26, 2022
Time: 7:00am (PDT),  10:00am (EDT), 4:00pm (CET)
 
Cell competition is a mechanism of interaction that dictates cell selection based on differences in cellular fitness. We developed a model of mixed murine organoids and enteroid monolayers to study such complex cellular interactions in a mammalian system. We combined this model with (time-lapse) microscopy and transcriptome analysis to show that cell competition drives growth of cancer cells by active out-competition of wild-type cells through forced cell death and cell-state change in a JNK-dependent manner.
 
Learning Objectives
  • Identify generation of mixed murine organoids and enteroid monolayers
  • Discuss the use of (time-lapse) microscopy to follow cellular behavior
  • Discover insight in the role of cell competition in tumor growth
 
 
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