OCT 29, 2019 7:00 AM PDT

Optimizing high-content screening tools for physiologically-relevant 3D in vitro models

Sponsored by: Molecular Devices
Speakers

Abstract

DATE: October 29, 2019

TIME: 7:00am PDT, 2:00pm GMT, 3:00pm CET

3D cell culture systems have recently emerged as tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM).  Join us for this webinar with HCS Pharma, a biotechnology start-up company based in France, as we discuss the biological characterization of cells in 3D matrices for liver, brain and adipose tissues, and cancer modeling, using BIOMIMESYS® hydroscaffold technology. We will also discuss high-content screening solutions for examining 3D in vitro models.

In this webinar, you will learn from Dr. Zied Souguir, inventor of the BIOMIMESYS® hydroscaffold, about the unique differentiation of this technology and its application for high-throughput drug screening.  Dr. Elodie Vandenhaute, a 3D cell culture expert at HCS Pharma, will demonstrate how to handle 3D cell culture systems such as the BIOMIMESYS hydroscaffold on high-content imagers, and how these can be integrated into HCS platforms in high throughput, such as HCS Pharma’s HAPIx platform. Finally, Daniel O’Connor, Drug Discovery Director (Molecular Devices) will discuss new High-Content Screening (HCS) technologies that are enabling researchers to capture more data at greater depths for 3D and thick tissue samples.

BIOMIMESYS® hydroscaffold technology mimics the native ECM and allows the culture of cells in a physiologically-relevant 3D cell culture system. It is based on hyaluronic acid, a major component of ECM currently under-represented in cell culture systems, and biofunctionalized with other ECM components according to the organ/tissue of interest. This matrix is provided in cell culture plates in a ready-to-use format and is compatible with all common downstream analytical techniques. It can be used to great benefit in early drug discovery as it is adapted to HCS, ADME-Tox profiling, and disease modeling. 
 

Key learning objectives:

  • Describe the differentiating factors between different 3D cell culture systems 
  • Utilizing a relevant 3D cell culture platform for liver, brain, adipose tissue, and disease modeling (human cells)
  • Optimizing setup of a high-content screening platform for 3D in vitro models

 

Webinars will be available for unlimited on-demand viewing after live event.

 

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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OCT 29, 2019 7:00 AM PDT

Optimizing high-content screening tools for physiologically-relevant 3D in vitro models

Sponsored by: Molecular Devices


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