MENU
FEB 24, 2021 1:30 PM PST

Roundtable Panel Presentation: Recent Trends in Screening GPCRs

C.E. Credits: P.A.C.E. CE Florida CE
Speakers

Abstract

G protein-coupled receptors (GPCRs) are among the most intensively studied drug targets, and account for about ~34% of all drugs approved by the FDA.  Examples of drugs targeting GPCRs include anti-histamines, β-blockers and ACE inhibitors. In the past, high-throughput methodologies for GPCR screening largely involved the measurement of second messenger production such as Ca2+, cAMP, and inositol phosphate (IP). Over the last decade there have been a number of advances in receptor pharmacology, breakthroughs in structural biology, and innovations in biotechnology, that together have led to several novel strategies to target this important receptor class. For example, since 2014, researchers have harnessed CRISPR technology to knockout (KO) GPCRs, GPCR-associated signaling proteins, or knock-in normal or mutated GPCRs. The panel will discuss some of these approaches including assays that directly quantify receptor coupling to heterotrimeric G proteins and β-arrestin, advancements using rational drug design and AI-based approaches, the increased interest in GPCR-targeting mAbs, and the increased appreciation for the role of pharmacogenomics.

Learning Objectives:

1. Identify some of the challenges to screening GPCRs

2. Describe some of the emerging technologies being used for GPCRs


Show Resources
You May Also Like
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
NOV 16, 2022 7:00 PM PST
C.E. CREDITS
NOV 16, 2022 7:00 PM PST
Date: November 16, 2022 Time: 2:00pm (AEST) Date: November 17, 2022 7:00pm (PST), 10:00pm (EST), 4:00am (CET) The growth in FDA-approved cell and gene therapy products for the treatment of d...
SEP 22, 2022 9:00 AM PDT
SEP 22, 2022 9:00 AM PDT
Date: September 22, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarke...
AUG 10, 2022 10:00 AM PDT
AUG 10, 2022 10:00 AM PDT
Date: August 10, 2022 Time: 10:00am PDT, 1:00pm EDT The global pandemic has increased focus and scrutiny on molecular diagnostic assay development, resulting in a need for assays that provid...
OCT 12, 2022 8:00 AM PDT
OCT 12, 2022 8:00 AM PDT
First Broadcast: Date: October 12, 2022 Time: 8:00am PDT, 11:00am EDT Second Broadcast: Date: October 12, 2022 Time: 9:00am SGT The new Embedded CryoSPARC Live, now fully integrated with t...
NOV 09, 2022 8:00 AM PST
NOV 09, 2022 8:00 AM PST
Date: November 09, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) The field of cell and gene therapy is rapidly growing. In particular, the use of lentiviruses in CAR-T applications is...
Loading Comments...
Show Resources