SEP 27, 2017 9:00 AM PDT

Regulation of actin during cell migration by nucleotide coding sequence and arginylation

Presented at: Cell Biology 2017
Speaker

Abstract

Actin cytoskeleton drives cell migration in muscle and non-muscle cells and plays a major role in such diverse processes as tissue morphogenesis, muscle contraction, and cancer metastases. In non-muscle cells, two major actin isoforms, beta and gamma actin, incorporate into different cytoskeletal structures and mediate cell migration and contractility. In our work we identified that beta, but not gamma actin, is possttranslationally arginylated, and that this arginylation is essential for normal cell migration. Differential arginylation of actin isoforms is regulated at the level of their nucleotide coding sequence. This regulation is a dynamic event that dynamically responds to cellular stimuli and is universal to multiple cell types. Thus, actin arginylation at the cell leading edge is a new regulatory process that acts at post-transcriptional and post-translational levels and is highly selective in targeting actin during cell migration.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
DEC 02, 2020 8:00 AM PST
C.E. CREDITS
DEC 02, 2020 8:00 AM PST
DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
JUN 09, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
NOV 16, 2020 8:00 AM PST
C.E. CREDITS
NOV 16, 2020 8:00 AM PST
Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
DEC 15, 2020 10:00 AM PST
C.E. CREDITS
DEC 15, 2020 10:00 AM PST
DATE: December 15, 2020 TIME: 10:00am PST Scientists from Thermo Fisher Scientific will walk us through the world of microorganisms. They will discuss their most recent research on viruses,...
SEP 27, 2017 9:00 AM PDT

Regulation of actin during cell migration by nucleotide coding sequence and arginylation

Presented at: Cell Biology 2017

Specialty

Research

Research And Development

Protein

University

Brain

Life Science

Clinical Medicine

Health

Drug Development

Animal Behavior

Chemistry

Genomics

Animal Research

Functional Medicine

Cell Biology

Geography

Asia67%

Europe33%

Registration Source

Website Visitors100%

Job Title

Student40%

Educator/Faculty20%

Medical Laboratory Technician20%

Marketing/Sales20%

Organization

Academic Institution33%

Veterinary School17%

Biotech Company17%

Manufacturer - Other17%

Other17%


Show Resources
Loading Comments...
Show Resources
Attendees
  • See more