APR 22, 2021 5:00 PM CEST

Researchers share their Spatial Discoveries in Neurology Research

Speakers

Abstract
Date:  April 22, 2021
Time: 8:00am (PDT),  11:00am (EDT),  5:00pm (CEST)
 
 
System transcriptomics of the schizophrenia brain - Phillip Khaitovich
Schizophrenia tops the psychiatric disorder list, both historically and clinically. Despite decades of research and dozens of hypotheses, we still do not understand its mechanisms. While the contemporary research focuses on the prefrontal cortex, our transcriptome assessment of 35 brain regions identified part of the temporal lobe and subcortical regions, including white matter tracks, as primary schizophrenia targets. Spatial transcriptome and proteome analyses of the prefrontal and temporal cortices confirmed this result, further revealing particular alterations of the superficial cortical layers involving genes linked to schizophrenia by the whole-genome association studies.
 
Single-cell gene expression studies in human Focal Cortical Dysplasia - Joan YW Liu
Focal Cortical Dysplasia (FCD) is the commonest malformation encountered in surgically-resected brain tissue of patients with Focal Epilepsy, and it is characterised by dyslamination and the presence of abnormal cell types, including dysmorphic neurons and balloon cells. It remains unclear how these abnormal cell types contribute to epileptogenesis. The work presented today shows results obtained using the GeoMx Digital Spatial cell Profiler technology to analyse the transcriptome of dysmorphic neurons and balloon cells in the surgically-resected brain samples of four patients with Focal Cortical Dysplasia Type IIB.
 
Learning Objectives:
  • Discover Spatial Genomics in Neuro Research
  • Learn from your peers about Neurology Spatial Discovery
  • Find out about the advancements in schizophrenia and epilepsy 
 
  • April 22: Researchers share their Spatial Discoveries in Neurology Research
    • Topics
      • System transcriptomics of the schizophrenia brain - Philipp Khaitovich
      • Single-cell gene expression studies in human Focal Cortical Dysplasia - Joan Liu
 
Webinars will be available for unlimited on-demand viewing after live event.

Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
JUL 15, 2021 9:00 AM PDT
JUL 15, 2021 9:00 AM PDT
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
NOV 17, 2021 8:00 AM PST
C.E. CREDITS
NOV 17, 2021 8:00 AM PST
Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
JUN 03, 2021 12:00 PM CST
JUN 03, 2021 12:00 PM CST
DATE: June 3, 2021 TIME: 12:00pm SGT This webinar is a virtual event that focuses on utilizing the Gibco CTS Rotea System for Cell and Gene Therapy...
Loading Comments...
Show Resources