MAR 14, 2018 10:30 AM PDT

Studying Sex-Specific Signaling to Understand Male Bias in Neurodevelopmental Disorders

Presented at: Neuroscience 2018
Speaker
  • Assistant Professor of Pharmacology and Physiology, and Integrative Systems Biology, GW Institute for Neuroscience
    BIOGRAPHY

Abstract

Since its initial description more than 70 years ago, autism spectrum disorder (ASD) has been diagnosed more frequently in boys. However, we remain unsure of why males are affected in greater numbers. Genetic and hormonal causes have been proposed, but clinicians and researchers are still debating whether males are more susceptible or females are more resilient. One primary hurdle in testing different hypotheses was the lack of appropriate animal models. In developing a novel mouse model of ASD and intellectual disability (ID) lacking Coiled-coil and C2 domain containing 1a, CC2D1A, which is mutated in humans with ID, ASD and seizures, we found that male mice are more severely affected than females. While males show an array of memory and sociability deficits with hyperactivity and anxiety, females only display a subset of learning impairments. In parallel, sex-specific behavioral differences correlate with male-specific reduction in activation of the transcription factor CREB in the hippocampus of KO animals. CREB function is critical for spatial memory formation, and modulation of CREB signaling rescues both molecular and behavioral deficits in male KO mice. Our results indicate that CC2D1A may establish male-specific signaling processes controlling memory. Defining how male-specific signaling is established will provide key insight on sex specific signaling in the brain, and will also lead to significant advances in the understanding of mechanisms that could lead to male bias in neurodevelopmental disorders.


Show Resources
You May Also Like
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
JUN 28, 2022 7:00 AM PDT
JUN 28, 2022 7:00 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
APR 26, 2022 7:00 AM PDT
C.E. CREDITS
APR 26, 2022 7:00 AM PDT
Date: April 19, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) High-content (HC) phenotypic profiling approaches are a powerful tool to study the effect of biological, genetic, and ch...
APR 28, 2022 8:00 AM PDT
APR 28, 2022 8:00 AM PDT
Date: April 28, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Human pluripotent stem cells (PSCs) and their derivatives hold great potentials in...
OCT 11, 2022 8:00 AM PDT
C.E. CREDITS
OCT 11, 2022 8:00 AM PDT
Date: October 11, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Multiomic profiling of cell populations at single-cell resolution is revolutionizing scientists’ understanding o...
MAR 14, 2018 10:30 AM PDT

Studying Sex-Specific Signaling to Understand Male Bias in Neurodevelopmental Disorders

Presented at: Neuroscience 2018


Show Resources
Loading Comments...
Show Resources
Attendees