FEB 14, 2019 9:00 AM PST

Tissue Chips: Building Confidence Through Independent Experimental Testing

C.E. Credits: RACE
Speaker
  • Professor, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University
    Biography
      Ivan Rusyn is Professor in the Department of Veterinary Integrative Biosciences in the College of Veterinary Medicine & Biomedical Sciences at Texas A&M University in College Station, TX. Prior to joining Texas A&M University, he was Professor of Environmental Sciences and Engineering at the University of North Carolina at Chapel Hill where he also served as an associate director of the Curriculum in Toxicology and deputy director of the Superfund Research Program. His laboratory has an active research portfolio with a focus on the mechanisms of chemical toxicity, the genetic determinants of susceptibility to toxicant-induced disease, and computational toxicology. He has served on many US national scientific committees and is currently a member of the National Research Council Committee on Toxicology. In addition, he is serving on the Board of the Scientific Councilors of the National Institute of Environmental Health Sciences and the Science Advisory Board for the NC Department of Environmental Quality. Dr. Rusyn served on seven World Health Organization/International Agency for Research on Cancer monograph working groups (as an overall chair, or a chair of "Mechanistic and Other Relevant Evidence" sub-group) and an expert for WHO-JMPR. His other service commitments include membership on the Research Committee of the Health Effects Institute in the United States. Dr. Rusyn received a doctor of medicine degree from Ukrainian State Medical University in Kiev and a Ph.D. in toxicology from UNC-Chapel Hill. He conducted postdoctoral research at the Massachusetts Institute of Technology and Heinrich-Heine University in Dusseldorf, where he was a DAAD fellow. Dr. Rusyn's laboratory has been funded by the grants and cooperative research agreements from the National Institutes of Health and US Environmental Protection Agency, and contracts with the American Chemistry Council and the European Petroleum Refiners Association (Concawe division).

    Abstract

    Experimental models that promise to replace animal tests that are currently required for drugs and chemicals are rapidly proliferating. This includes a number of novel solutions offered by biomedical engineers that are collectively known as microphysiological systems or tissue chips. These elegant models aim to recreate a tissue or a physiological function using human cells that are usually cultured in 3D structures and under media flow. However, while the advances in biomedical engineering and material science are truly encouraging, there has been a challenge of transferring these technologies from the developer labs to the end-users. One of the barriers to the technology transfer of tissue chips has been a concern that these devices are too difficult to operate as they require specialized equipment, knowledge and experience; hence, the confidence in how well tissue chips perform is yet to be established. To bridge the gap developments in tissue chips and their use for decision making in drug development and chemical safety evaluation, the National Center for Advancing Translational Sciences has funded several Centers to test tissue chips in an independent third-party environment. This presentation will detail the experiences of one such center at Texas A&M University. 

    Learning Objectives: 

    1. To become familiar with the diversity of current options for the Microphysiological Systems (also known as Tissue Chips)
    2. To understand how these microphysiological systems may be tested with respect to reproducibility and technology transfer.


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