MAR 15, 2017 7:30 AM PDT

Exercise Targeting Neuroplasticity in Parkinson's disease

Presented at: Neuroscience 2017
Speaker
  • Associate Professor and Clinical Scholar in Neurology and Movement Disorders, University of Southern California, Keck School of Medicine
    Biography
      Giselle M. Petzinger, MD, is an Associate Professor and Clinical Scholar in Neurology and Movement Disorders at The University of Southern California, Keck School of Medicine in the department of neurology. She completed her MD degree at University of Southern California, her neurology residency at Yale University, and her Fellowship in movement disorders at Columbia University. Her research primarily focuses on elucidating the underlying molecular mechanisms by which different forms of exercise target and facilitate repair of cognitive and motor circuitry, through processes collectively termed neuroplasticity. Her research involves both animal models of PD and clinical studies with patients thus providing the foundation for a translational research program spanning the spectrum from bench to bedside. She has been funded by national Parkinson foundation, NIH and US Army and has published extensively in the field of PD and exercise and repair. Dr. Petzinger is also committed to promoting education of wellness and lifestyle practices to facilitate disease prevention and to improve the quality of life for individuals of all ages. Towards this goal she has participated in developing as well as teaching educational health and wellness programs at universities both within the United States and abroad.

    Abstract

    Parkinson’s disease (PD) is characterized by the loss of dopamine and the disruption of brain circuits (basal ganglia and cortex) that are responsible for normal cognitive and motor performance.  Investigations utilizing animal models of PD serve as an important first translational research step for identifying therapeutic targets that can be used to identify and guide novel therapeutic treatments for modifying disease progression in PD. Studies from our lab and others have demonstrated that exercise can improve motor and cognitive function in PD.  Using animal models of PD, our lab has also shown evidence of exercise-induced neuroplasticity through modulating dopaminergic and glutamatergic neurotransmission and enhancing basal ganglia synaptic connections. Animal studies in our lab also suggest that the type of exercise performed, e.g. aerobic vs. skill based exercise, may play differential roles on these repair mechanisms.  Specifically, using a rodent model of striatal dopamine depletion we have provided the first evidence that skilled exercise compared to simple aerobic exercise increases functional recruitment of prefrontal cortex (PFC), a brain region central to cognition, and in particular executive function.  Ongoing studies in our lab investigate the molecular mechanisms that underlie exercise-induced alterations of regional blood flow and neuronal metabolic demand including the transcription factor hypoxia inducible factor HIF-1α.  Findings from these studies will elucidate mechanism(s) of exercise-induced neuroplasticity and repair and help guide exercise interventions in PD.

     

    Learning Objectives:

    1. Define Neuroplasticity and understand it’s potential role in mechanisms of repair of Parkinson’s disease.
    2. Understand the role that exercise may play in modulating dopamine and glutamate neurotransmission within the basal ganglia.
    3. Understand the role of exercise on synaptogenesis in animal models of PD.
    4. Describe different types of exercises that may be beneficial in enhancing cognitive function in PD.

    Show Resources
    You May Also Like
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    NOV 18, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    SEP 02, 2020 7:00 AM PDT
    C.E. CREDITS
    SEP 02, 2020 7:00 AM PDT
    DATE: September 2, 2020 TIME: 03:00pm PDT, 6:00pm EDT Spatial omics is an expanding collection of methods to examine biological molecules in their geographical context. By retaining the prec...
    NOV 16, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    NOV 10, 2020 7:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    NOV 10, 2020 7:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: November 10, 2020 TIME: 7:00am PDT, 10:00am EDT Automation can provide tremendous benefits such as increased pipetting precision and accuracy, productivity, and throughput. Numerous wo...
    Loading Comments...
    Show Resources
    Attendees
    • See more