SEP 13, 2018 10:30 AM PDT

Understanding and Inhibiting Horizontal Gene Transfer of Antibiotic Resistance

C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Postdoctoral Scholar, Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard
    Biography
      Allison J. Lopatkin, PhD, works as a Postdoctoral Fellow in the Institute for Medical Engineering and Sciences at the Massachusetts Institute of Technology and the Infectious Disease and Microbiome group at the Broad Institute of MIT and Harvard, as a member of the Collins Lab. She completed her PhD training in Biomedical Engineering at Duke University, and her BS training in Applied Mathematics at the University of Rochester. Allison's work uses quantitative methods to study the spread of antibiotic resistance within bacterial populations, including synthetic biology approaches and mathematical modeling. Her current research interests include evolutionary dynamics of bacterial communities, leveraging horizontal gene transfer to target pathogens, and adjuvant discovery to extend the efficacy of existing antibiotics.

    Abstract:

    Horizontal gene transfer (HGT) – or the non-genealogical transmission of DNA between organisms – is the dominant mode responsible for the spread of antibiotic resistance genes. Combined with antibiotic overuse and misuse, HGT (primarily via conjugation) has compromised the efficacy of nearly every single antimicrobial available. Traditionally, reducing overall antibiotic use has been the primary approach to reversing resistance. However, despite widespread antibiotic stewardship initiatives, resistance can persist for long periods of time.  In this webinar, we discuss the prevalence of plasmid-mediated antibiotic resistance, the role of HGT in maintaining antibiotic resistance even in the absence of antibiotic selection, and how we can use mathematical modeling to guide novel intervention strategies towards minimizing this risk.
     

    Learning Objectives: 

    1. What is horizontal gene transfer
    2. How is HGT relevant to antibiotic resistance
    3. Using mathematical modeling to understand HGT dynamics and guide useful therapeutic approaches


    Show Resources
    You May Also Like
    SEP 05, 2019 4:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 4:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    NOV 18, 2019 7:00 AM PST
    C.E. CREDITS
    NOV 18, 2019 7:00 AM PST
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    AUG 27, 2019 9:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 9:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    DEC 05, 2019 9:00 AM PST
    C.E. CREDITS
    DEC 05, 2019 9:00 AM PST
    DATE: December 5, 2019TIME: 9:00am PST, 12:00pm EST Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues e...
    Loading Comments...
    Show Resources
    Attendees