Rob van 't Hof is professor of musculoskeletal biology at the University of Liverpool. His main interest is the regulation of bone turnover, especially in relation to age related bone loss and bone disease. He has extensive experience in using µCT for phenotyping transgenic animal models of bone disease. Using these techniques, he has investigated the role of different nitic oxide synthases in bone, developed a mouse model of Paget's disease of bone and developed a novel class of anti-inflammatory drugs that also inhibit bone resorption. He has more than 10 years' experience in bone phenotyping of transgenic mice, and during this time has developed approaches for high throughput CT analysis. To complement the µCT analysis he has also developed software for semi-automated dynamic bone histomorphometry.


Selected Papers:

1. Daroszewska A, Rose L, Sarsam N, Charlesworth G, Prior A, Rose K, Ralston SH, van 't Hof RJ. Zoledronic acid prevents Pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease. Dis Model Mech. 2018 Aug 23;11(9). pii: dmm035576. doi: 10.1242/dmm.035576.
2. Chau Y, Brownstein D, Mjoseng H, Perry P, Lee W, Berry R, Thornburn A, Sexton D, Hohenstein P, Morton N, Freyer E, Samuel K, van 't Hof RJ, Hastie N. Acute multiple organ failure in adult mice deleted for the developmental regulator, Wt1. PLoS Genet. 2011;7(12):e1002404.
3. Coste E, Greig IR, Mollat P, Rose L, Gray M, Ralston SH, van 't Hof RJ. Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice. Ann Rheum Dis. 2015 Jan;74 (1) :220-6