Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture

Sponsored by: Bruker Microbiology & Diagnostics

Speaker

Rob van 't Hof, BSc, MSc, PhD

Professor of Musculoskeletal Biology The Institute of Ageing & Chronic Disease University of Liverpool.
BIOGRAPHY

Abstract

DATE: December 6, 2018

TIME: 11:00am EST, 5:00pm CET

Introduction

Micro-computed tomography (micro-CT) offers significant advantages over other X-ray imaging techniques in the field of bone research. Its high-level X-ray absorption enables good contrast and the ability to observe bone in very fine detail, not only in bone density studies, but also those examining the actual architecture of the bone.

Seminar Overview

In this webinar, professor of musculoskeletal biology, Rob van 't Hof, will discuss the application of micro-CT for the analysis and phenotyping of bone. Most of the studies described will be ex vivo, but a few examples of in vivo micro-CT will also be given. Rob and team have used micro-CT to assess bone phenotype in transgenic mice, to test the efficacy of drugs targeting post-menopausal osteoporosis and to understand the bone condition Paget’s disease. For their studies, the team has used Bruker’s ex vivo SkyScan 1272 with automated sample loader as well as a SkyScan high resolution in vivo micro-CT.

What to Expect

Attendees will hear how micro-CT can be used to analyse mouse bone phenotypes and the bones’ response to osteoporosis drugs, as well as how to look in vivo at the bone changes that occur in mice with Paget’s disease over their lifespan. Automated analysis of the scans will also be discussed.

Key Topics

How individuals working in biomedical and preclinical research can use high-throughput micro-CT for bone phenotyping and analysis of bone architecture
Examples of studies looking at bone phenotyping, responses to osteoporosis drugs and Paget’s disease
Techniques that have been developed to make processes run efficiently and automatically, whilst delivering reliable results
Introduction to Bruker’s ex vivo SkyScan 1272 as well as a SkyScan high resolution in vivo micro-CT

Who Should Attend

The webinar will interest researchers in the biomedical, medical, and preclinical world, including both experienced and novice users of instruments such as SkyScan. Anyone interested in applying micro-CT for preclinical or patient-based research in areas such as orthopedics, endocrinology, tissue engineering and forensics would benefit.