FEB 27, 2019 10:30 AM PST

In Vivo Surgical Models for Drug Discovery: Hidden Pitfalls and Their Avoidance

Presented at: Drug Discovery 2019
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Senior Manager InVivo Sciences, Charles River
    Biography
      Matt entered the research field almost 30 years ago as a lab animal technician at the TSI/Mason contract research facility in Worcester, Massachusetts. Since then, he has worked in laboratory contract facilities such as Primedica and OREAD Biosafety, as well as within the biotech/pharma industry at Pharmacia, Pfizer, Genzyme/Sanofi-Aventis, and Biogen. Matt joined Charles River Laboratories last year as the senior manager of the In Vivo Sciences department at their Shrewsbury, Massachusetts facility. During his career, Matt has performed a variety of surgical procedures including device implantation, organ transplants, orthopedic defect, ocular and vascular implants, cardiac procedures, fibrosis modelling and brain and spinal procedures. His experience ranges from mice and rats to non-human primates and livestock. He holds patents for novel surgical devices and implants and has been training technicians, scientists, veterinarians, and physicians in surgical techniques and procedures for over 20 years. He is currently also an adjunct professor at the Worcester Polytechnic Institute, teaching the graduate-level Laboratory Animal Surgery course. Outside of the surgical realm, he has been a toxicology and pharmacology study director, cardiac sonographer, safety pharmacology scientist, and manager. Currently, Matt manages a team of over 70 technicians, trainers, data reviewers, team leaders, and supervisors. Matt served on the board of directors for the Academy of Surgical Research for over ten years, including as the program chair for three years and the educational chair for two years. He is the current president for the New England branch of AALAS.

    Abstract

    Over the past 25 years surgically dependent animal models have expanded from a small, almost niche area in pharmaceutical research to an important component of most research portfolios.  In this current environment the importance for researchers to understand the effects of anatomic and physiologic differences between the species, the requirement for aseptic technique to avoid confounding complications and the requirement for trained and conscientious surgeons is ever more critical.  This presentation will discuss some of the subtle ways that the performance of a surgical procedure can significantly affect the experimental results, the importance of proper model, species and strain selection and some common mistakes that the author has observed over the past quarter century.

    Learning Objectives: 

    1. Demonstrate the need for a high level of surgical technique and attention to asepsis, anesthesia and analgesia to provide valid and reproducible data 
    2. Describe a methodology to identify, design, and plan a high quality surgical protocol


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