Dr. Takebe is an Associate Director of Center for Stem Cell and Organoid Medicine (CuSTOM) at the Cincinnati Children's Hospital Medical Center and Professor at Yokohama City University, and Tokyo Medical and Dental University, Japan. He serves as Board of Directors at International Society of Stem Cell Research (ISSCR). His lab investigates the mechanisms of human organogenesis, and develops mini-organ technologies from human stem cells - namely organ bud based approaches. He is applying iPSC-liver buds into drug discovery study as well as transplant application - for patients with a rare congenital metabolic disorder, ultimately expanding the clinical indications to diseases like liver cirrhosis.