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Image manipulation scandals and tightening journal guidelines have put traditional Western blots under a spotlight: every manual step—from gel casting to image export—adds variab...
The COVID-19 pandemic has taken a dramatic toll worldwide. Its impact possibly has been the most palpable amongst uniquely vulnerable groups of patients, such as patients with a cancer diagn...
Central to the diagnosis and management of patients with diabetes mellitus is the measurement of hemoglobin A1c (HbA1c). Major studies have defined the therapeutic targets of HbA1c in order...
Arrayed gene knockout (KO) libraries represent a valuable resource for performing functional genomics screening. Current generation arrayed KO libraries for the whole human genome rely on eit...
As viral threats continue to emerge, viral detection assays are important not only for recognizing if a virus is present, but also for surveillance and variant characterization. Accurate det...
Access this training to learn more about different techniques that can be used for successful colony selection and passage of induced pluripotent stem cells....
Learning Objectives 1. Identify 3 obstacles that inhibit the immune cell response to cancer. 2. List 3 aspects of T cells antitumor function that can be improved with costimulatory signals....
Revolutionary sequencing technologies are enabling whole transcriptome profiling of tens to hundreds of thousands of single cells in parallel, in a single experiment. This has led to an expl...
With over 265,000 new cases per year and over 50,000 deaths, breast and ovarian cancers represent a significant health burden in the USA. Prior work has demonstrated that CD4 helper T c...
Gene therapy is defined as the treatment of disease by transfer of genetic material into cells, to prevent, treat and potentially even cure a disease. Gene therapies can work by several mech...
Cannabis prohibition has been prevalent since the 1930’s and has had a dramatic negative impact on patients, veterans and small business owners. As a small business owner serving patien...
Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
Open Targets is a public-private partnership made up of four global leading institutions in the fields of pharmaceuticals, bioinformatics and genomics, GSK, EMBL-EBI, the Wellcome Trust Sange...
Genomic profiling of liquid biopsies is no longer an emerging area of clinical research, but quickly becoming translated as part of contemporary clinical trials for potential future use in t...
Interest in cell and gene therapy-based disease prevention and treatment has increased rapidly over the last few decades, however there are still many hurdles to overcome and further progres...
Historically the analysis and study of cannabis and cannabis-related molecules has been challenging because of their collective legal status. With the passage of the 2018 Farm Bill, at least...
The ability of single-cell RNA-Seq (scRNA-Seq) to measure the transcriptional basis of heterogeneity between individual cells is transforming biomedical research. It enables the precise &lsq...
Most currently used conventional influenza vaccines are based on 1940s technology. Advances in immunogen design and vaccine delivery emerging over the last decade open novel opportunities fo...
Mitochondrial defects represent a common pathogenetic mechanism associated with neurodegeneration. At the same time, mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases...
Over the past 6 years, a number of agents, all mechanistically different, have been approved with a statistically significant survival benefit as monotherapy for treatment of metastatic castr...
The routine analysis of steroid hormones is critical in understanding the function of metabolic pathways that impact sexual characteristics, inflammation and blood pressure. Liquid Chromatog...
Therapies that activate the host immune system have shown tremendous promise for a wide variety of solid tumors. However, in most cancer types, fewer than half of patients respond to these th...
Image manipulation scandals and tightening journal guidelines have put traditional Western blots under a spotlight: every manual step—from gel casting to image export—adds variab...
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