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Infectious diseases have been a major threat to human health throughout history, causing significant economic damage worldwide. In modern medicine, quickly and accurately identifying the ger...
Deregulation of Receptor Tyrosine Kinase (RTK) signaling underlies a large fraction of human cancers. These genetic perturbations lead to a variety of cell autonomous and non-cell autonomous...
Epidemics are occurring at an increasing pace and scale. Our laboratory group has developed platform technologies for discovery of broad and potent neutralizing antibodies for many emerging...
Inborn errors of metabolism (IEMs) are rare, devastating disorders caused by pathogenic variants in genes encoding key metabolic enzymes, with the liver playing a critical role in over 140 I...
Emerging viruses like SARS, SARS-CoV-2, MERS-CoV, Hendra, Nipah, West Nile, sin nombre, LuJo, MERS, Powassan, dengue, chikungunya, zika, Ebola, and Marburg pose a growing threat to public he...
Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by mutations in the SMN1 gene that reduce survival motor neuron (SMN) protein expression. Despite progress in the...
Lessons around leveraging high-complexity next-generation sequencing tests for precision infectious disease discovery to guide patient treatment and improve health outcomes. Learning Objecti...
Solid phase microextraction (SPME) is a versatile, non-exhaustive sample preparation tool that has been demonstrated to be well-suited for facile and effective analysis of a broad range of c...
Advancements in immuno-oncology have been moving at an ever-quickening pace. From the development of new CAR-T therapies to a better understanding of the mechanism of action of monoclonal an...
Genomics has had rapid implementation over the past decade, with recent growth in application in oncology, mental health, maternal fetal medicine, solid organ transplantation, and more. Much...
Date: September 16, 2021 Time: 8:00am (PDT), 11:00am (EDT) Rapid screening and speed of scale-up in protein therapeutics are critical factors in today’s biotech and pharma workflows. T...
This presentation explores the pharmacokinetics (PK) and pharmacodynamics (PD) of β-lactam antibiotic dosing, particularly in ICU patients. To optimize PK/PD targets, two strategies are...
The recent outbreak of the Coronavirus Disease 2019 (COVID-19) has spread all over the world and raised global concerns. Rapid and early detection of the novel coronavirus SARS-CoV-2, the ca...
Prostate cancers are considered immunologically ‘cold’ tumors given the very few patients who respond to checkpoint inhibitor therapy (CPI). Recently, enrichment of interferon st...
Despite the immense promise of cancer immunotherapies, significant challenges have been mounting to overcome treatment resistance and to improve efficacy. Strategies such as the combination...
Learning Objectives: 1. Discuss the conceptual limitations of the term, "population" as applied to human genomics. 2. Explain the main difference(s) between "race", "...
Current methods used to predict safety and efficacy of candidate drugs accounts for as much as 90% failure rate. Approximately 30% of drugs have failed......
The spread of severe acute respiratory syndrome coronavirus 2 (SARS CoV2), changed the daily life of medical oncologists. To keep safe both patients and healthy workers is the most important...
The Moonshot program was established in the UK by The Department of Health and Social Care to explore novel technologies for the detection of SARS-COV-2. Mass spectrometry was identified as...
This presentation will describe two microfluidic techniques that my research group has developed for single-cell manipulation and analysis. The first is called Digital microfluidic Isolation...
Learning Objectives: 1. Describe and discuss some of the unique aspect of in vivo studies. 2. Identify specific study practices to ensure high quality study data and animal welfare. 3. Discu...
Learning Objectives: 1. Review the basic principle of 3D microscopy. 2. Recognize the pathophysiology of Parkinson disease. 3. Demonstrate knowledge on how alpha-synuclein aggregates spread...
The last 20 years have seen an explosion of genetic information and data. New technological advances have made it faster and less expensive to understand the human genomes but most of those...
Acute lymphoblastic leukemia is the most common cancer in children and adolescents. While current treatments have resulted in 85-90% cure, the remaining 10-15% cases represent the leading cau...
Current methods to treat malignant brain tumors are highly intrusive, leading to poor quality of life with abysmal patient survival rates. Combined with radiation therapy, first/second-line...
Infectious diseases have been a major threat to human health throughout history, causing significant economic damage worldwide. In modern medicine, quickly and accurately identifying the ger...
