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    Cancer Biomarker

    Cancer Biomarker: refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer.

    Webinars

    • SEP 15, 2022 | 9:00 AM
      Advances and Challenges in Targeting Kinases in Cancer Therapeutics
      Advances and Challenges in Targeting Kinases in Cancer Therapeutics
      Date: September 15, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Tyrosine kinases, a ubiquitous and diverse family of enzymes, are of considerable clinical interest because they dir...
      Speaker: Aishath Shanaz Naeem , Veronique Baron
      Sponsored By: BPS Bioscience
      9
      JUN 30, 2022 | 9:00 AM
      The PCR Advantage: How the Biomark™ HD System Enhances the TruGraf® Gene Expression Test for Kidney Rejection
      The PCR Advantage: How the Biomark™ HD System Enhances the TruGraf®...
      Date: June 30, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Subclinical acute rejection (SubAR) is a significant risk for kidney transplant recipients, affecting 1 in 4 patients. Ea...
      Speaker: Juston Weems, Ph.D.
      Sponsored By: Standard BioTools
      8
      JUN 29, 2022 | 6:00 AM
      TSH & Thyroid Function Tests: why their performance matters
      TSH & Thyroid Function Tests: why their performance matters
      Date: June 29, 2022 Time: 6:00am (PDT), 9:00am (EDT), 8:00pm (CEST) Thyroid Function Tests (TFTs) are among the most commonly requested laboratory investigations and are help clinicians asse...
      Speaker: Finlay MacKenzie , Prof. Dražen Huić, MD
      Sponsored By: Abbott
      34
      JUN 21, 2022 | 10:00 AM
      Delivering Single-Molecule Proteomics at Scale using Protein Identification by Short epitope Mapping
      Delivering Single-Molecule Proteomics at Scale using Protein Identification...
      Date: June 21, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) The proteome is perhaps the most dynamic and valuable source of functional biological insight. Here, we introduce a novel...
      Speaker: Parag Mallick, Ph.D.
      Sponsored By: Nautilus Biotechnology
      9
      JUN 21, 2022 | 6:00 AM
      The future of predictive genomics in Israel
      The future of predictive genomics in Israel
      Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
      Speaker: Zisis Kozlakidis , David Hanna , Dr. Yehudit Cohen , Sowmiya Moorthie , Shai Carmi
      Sponsored By: Thermo Fisher Scientific
      27
      MAY 24, 2022 | 11:00 AM
      Next-Generation Sequencing (NGS) Assessment of Homologous Recombination Deficiency (HRD): Expanding NGS Data to View Events Associated with Genomic Instability
      Next-Generation Sequencing (NGS) Assessment of Homologous Recombination...
      Date: May 24, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 7:00pm (CEST) NGS tumor profiling has become the mainstay of modern cancer therapy. Several NCCN-guided and FDA-approved therapies are c...
      Speaker: Dr. Christopher Lum, M.D. , Zan Halford, M.S. SMB(ASCP)CM,
      Sponsored By: BioDiscovery, A Bionano Genomics Company
      18
      MAY 04, 2022 | 3:00 PM
      Deep Spatiotemporal Insights into COVID-19: a Multi-organ Study
      Deep Spatiotemporal Insights into COVID-19: a Multi-organ Study
      The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in late 2019 has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 2019...
      Speaker: Arutha Kulasinghe, PhD
      Presented at: Coronavirus Series
      Sponsored By: NanoString Technologies
      6
      APR 21, 2022 | 5:30 AM
      Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting Hypoxia
      Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting...
      A hypoxic tumour microenvironment is a feature of solid tumours. Many tumour types contain high fractions of hypoxic tissue. The relationship between high levels of tumour hypoxia and a poor...
      Speaker: Joely Irlam
      Presented at: Genetics Week Virtual Event Series 2022
      2
      APR 20, 2022 | 7:30 AM
      Keynote Presentation: Laboratory Assessment of Covid-19 Immunity in Patients with a Cancer Diagnosis: Alpha to Omicron
      Keynote Presentation: Laboratory Assessment of Covid-19 Immunity...
      The COVID-19 pandemic has taken a dramatic toll worldwide. Its impact possibly has been the most palpable amongst uniquely vulnerable groups of patients, such as patients with a cancer diagn...
      Speaker: Balazs Halmos, MD
      Presented at: Genetics Week Virtual Event Series 2022
      3
      APR 19, 2022 | 3:00 PM
      Using NGS for MicroRNA and Gene Expression Analysis with Integrated Bioinformatics for Pathway Discovery and Biomarker Verification
      Using NGS for MicroRNA and Gene Expression Analysis with Integrated...
      MicroRNAs (miRNAs) are small RNAs with an average size of 22 nucleotides that regulate gene expression through various mechanisms. During the last decade, researchers have identified over 26...
      Speaker: Samuel Rulli, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: QIAGEN
      1
      APR 19, 2022 | 12:00 PM
      Advances in Targeted Sequencing: Accelerate Your NGS Workflows with New QIAseq Chemistry
      Advances in Targeted Sequencing: Accelerate Your NGS Workflows...
      Targeted sequencing has many applications in cancer biomarker research, carrier screening and inherited disorders, drug development, mitochondrial DNA variant detection, human ID and paterni...
      Speaker: Krishna Amin
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: QIAGEN
      1
      MAR 22, 2022 | 7:00 AM
      Spatio-temporal characterization and quantification of DNA replication events by molecular combing
      Spatio-temporal characterization and quantification of DNA replication...
      Date: March 22, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) DNA replication happens at the very early stage of cell development, at such early stages of development...
      Speaker: Cyndie Forestier
      Sponsored By: Genomic Vision
      7
      FEB 23, 2022 | 11:55 PM
      Identification of Novel Protein Biomarkers in the Era of Precision Medicine Oncology
      Identification of Novel Protein Biomarkers in the Era of Precision...
      Cancer is a leading cause of morbidity and mortality in developed countries including the United States. Early detection of various cancers, before they spread and become incurable, has been...
      Speaker: Hilal Arnouk, MD, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2022
      3
      FEB 23, 2022 | 11:55 PM
      Next Generation Biobanking of Patient-derived Organoid Models
      Next Generation Biobanking of Patient-derived Organoid Models
      Princess Margaret Living Biobank (PMLB) is a repository for patient-derived organoid models. PMLB has generated over200 organoid models from lung, pancreas, colon, ovary, esophageal and brea...
      Speaker: Nikolina Radulovich, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2022
      1
      FEB 23, 2022 | 1:30 PM
      Innovative Approaches to Biomarker Discovery in the Drug Development Process
      Innovative Approaches to Biomarker Discovery in the Drug Development...
      High-throughput sequencing technology such as RNASeq and whole genome sequencing has enabled deep characterization of health and disease states. Biomarker discovery by these means has only h...
      Speaker: Esperanza Anguiano, PhD, MS-MBA
      Presented at: Drug Discovery & Development Virtual Event Series 2022
      Sponsored By: NanoString Technologies
      2
      FEB 23, 2022 | 6:00 AM
      Autoantibodies as Biomarkers in Immuno-oncology
      Autoantibodies as Biomarkers in Immuno-oncology
      Cancer still accounts for nearly 1 in every 4 deaths worldwide. New immunotherapies have the power to induce durable responses in patients with fatal cancers, but only a small percentage of...
      Speaker: Hans-Dieter Zucht, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2022
      Sponsored By: Luminex - A DiaSorin Company
      10
      JAN 20, 2022 | 8:00 AM
      Modernization of tissue-based, biomarker-led clinical research
      Modernization of tissue-based, biomarker-led clinical research
      Date: January 20, 2021 Time: 08:00am (PST), 11:00am (EST) Automated staining platforms and digital slide scanners have revolutionized tissue-based biomarker research by providing a powerful...
      Speaker: Dr Stephanie Craig
      Sponsored By: Leica Biosystems
      15 1
      DEC 01, 2021 | 7:00 AM
      Using multiplex immunofluorescence to predict clinical outcomes in solid tumor cancer
      Using multiplex immunofluorescence to predict clinical outcomes...
      Date: December 01, 2021 Time: 7:00am (PST), 10:00am (EST) In the era of immuno-oncology, there is a growing need for the identification of new biomarkers predictive for sensitivity to anti-P...
      Speaker: Alban BESSEDE
      Sponsored By: Akoya Biosciences
      10 1
      OCT 14, 2021 | 9:00 AM
      Session 3: Simple steps to publication-quality western blots
      Session 3: Simple steps to publication-quality western blots
      Date: October 14, 2021 Time: 9:00am (PDT), 12:00pm (EDT), 5:00pm GMT Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring spe...
      Speaker: Kelli Feather-Henigan
      Presented at: Webinar series: Simple steps to publication-quality western blots
      Sponsored By: Thermo Fisher Scientific
      28
      OCT 13, 2021 | 7:00 AM
      Session 2: Simple steps to publication-quality western blots
      Session 2: Simple steps to publication-quality western blots
      Date: October 13, 2021 Time: 7:00am (PDT), 10:00am (EDT) Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring specific target...
      Speaker: Caleb Shearrow
      Presented at: Webinar series: Simple steps to publication-quality western blots
      Sponsored By: Thermo Fisher Scientific
      31 1
      OCT 07, 2021 | 12:00 PM
      Panel Presentation: Oncology Variant Interpretation Just Got More Precise
      Panel Presentation: Oncology Variant Interpretation Just Got More...
      Across oncology applications, from research to molecular testing and pharmaceutical development, the ability to identify potentially actionable genetic alterations and exploit the molecular...
      Speaker: Beate Litzenburger, Ph.D. , Sheryl Elkin, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
      Sponsored By: QIAGEN
      2
      SEP 29, 2021 | 10:00 AM
      Study design: How and when to use multiplexed immunofluorescence imaging in your research
      Study design: How and when to use multiplexed immunofluorescence...
      Date: September 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Multiplexed tissue analysis is a powerful technique that allows comparisons of cell-type locations and cell-type interactions withi...
      Speaker: Melinda Angus-Hill Ph.D.
      Sponsored By: Leica Microsystems
      5
      SEP 28, 2021 | 9:00 AM
      New method for standardized, high-throughput PBMC isolation from blood samples for observational and clinical studies
      New method for standardized, high-throughput PBMC isolation from...
      Date: September 28, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Standardization and reproducibility are prerequisites for peripheral blood mononuclear cell (PBMC) generation from donor or patient...
      Speaker: Lotta Raty , Dr. Steffen Rapp , PhD
      Sponsored By: Miltenyi Biotec
      10 1
      SEP 14, 2021 | 7:00 AM
      What prevents you from increasing your PCR productivity?
      What prevents you from increasing your PCR productivity?
      Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
      Speaker: Arora Phang, PhD
      Sponsored By: Eppendorf
      24 1
    SEP 15, 2022 | 9:00 AM
    Advances and Challenges in Targeting Kinases in Cancer Therapeutics
    Advances and Challenges in Targeting Kinases in Cancer Therapeutics
    Date: September 15, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Tyrosine kinases, a ubiquitous and diverse family of enzymes, are of considerable clinical interest because they dir...
    Speaker: Aishath Shanaz Naeem , Veronique Baron
    Sponsored By: BPS Bioscience
    9
    JUN 30, 2022 | 9:00 AM
    The PCR Advantage: How the Biomark™ HD System Enhances the TruGraf® Gene Expression Test for Kidney Rejection
    The PCR Advantage: How the Biomark™ HD System Enhances the TruGraf®...
    Date: June 30, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Subclinical acute rejection (SubAR) is a significant risk for kidney transplant recipients, affecting 1 in 4 patients. Ea...
    Speaker: Juston Weems, Ph.D.
    Sponsored By: Standard BioTools
    8
    JUN 29, 2022 | 6:00 AM
    TSH & Thyroid Function Tests: why their performance matters
    TSH & Thyroid Function Tests: why their performance matters
    Date: June 29, 2022 Time: 6:00am (PDT), 9:00am (EDT), 8:00pm (CEST) Thyroid Function Tests (TFTs) are among the most commonly requested laboratory investigations and are help clinicians asse...
    Speaker: Finlay MacKenzie , Prof. Dražen Huić, MD
    Sponsored By: Abbott
    34
    JUN 21, 2022 | 10:00 AM
    Delivering Single-Molecule Proteomics at Scale using Protein Identification by Short epitope Mapping
    Delivering Single-Molecule Proteomics at Scale using Protein Identification...
    Date: June 21, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) The proteome is perhaps the most dynamic and valuable source of functional biological insight. Here, we introduce a novel...
    Speaker: Parag Mallick, Ph.D.
    Sponsored By: Nautilus Biotechnology
    9
    JUN 21, 2022 | 6:00 AM
    The future of predictive genomics in Israel
    The future of predictive genomics in Israel
    Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
    Speaker: Zisis Kozlakidis , David Hanna , Dr. Yehudit Cohen , Sowmiya Moorthie , Shai Carmi
    Sponsored By: Thermo Fisher Scientific
    27
     
     
  • MAY 24, 2022 | 11:00 AM
    Next-Generation Sequencing (NGS) Assessment of Homologous Recombination Deficiency (HRD): Expanding NGS Data to View Events Associated with Genomic Instability
    Next-Generation Sequencing (NGS) Assessment of Homologous Recombination...
    Date: May 24, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 7:00pm (CEST) NGS tumor profiling has become the mainstay of modern cancer therapy. Several NCCN-guided and FDA-approved therapies are c...
    Speaker: Dr. Christopher Lum, M.D. , Zan Halford, M.S. SMB(ASCP)CM,
    Sponsored By: BioDiscovery, A Bionano Genomics Company
    18
    MAY 04, 2022 | 3:00 PM
    Deep Spatiotemporal Insights into COVID-19: a Multi-organ Study
    Deep Spatiotemporal Insights into COVID-19: a Multi-organ Study
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in late 2019 has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 2019...
    Speaker: Arutha Kulasinghe, PhD
    Presented at: Coronavirus Series
    Sponsored By: NanoString Technologies
    6
    APR 21, 2022 | 5:30 AM
    Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting Hypoxia
    Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting...
    A hypoxic tumour microenvironment is a feature of solid tumours. Many tumour types contain high fractions of hypoxic tissue. The relationship between high levels of tumour hypoxia and a poor...
    Speaker: Joely Irlam
    Presented at: Genetics Week Virtual Event Series 2022
    2
    APR 20, 2022 | 7:30 AM
    Keynote Presentation: Laboratory Assessment of Covid-19 Immunity in Patients with a Cancer Diagnosis: Alpha to Omicron
    Keynote Presentation: Laboratory Assessment of Covid-19 Immunity...
    The COVID-19 pandemic has taken a dramatic toll worldwide. Its impact possibly has been the most palpable amongst uniquely vulnerable groups of patients, such as patients with a cancer diagn...
    Speaker: Balazs Halmos, MD
    Presented at: Genetics Week Virtual Event Series 2022
    3
    APR 19, 2022 | 3:00 PM
    Using NGS for MicroRNA and Gene Expression Analysis with Integrated Bioinformatics for Pathway Discovery and Biomarker Verification
    Using NGS for MicroRNA and Gene Expression Analysis with Integrated...
    MicroRNAs (miRNAs) are small RNAs with an average size of 22 nucleotides that regulate gene expression through various mechanisms. During the last decade, researchers have identified over 26...
    Speaker: Samuel Rulli, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: QIAGEN
    1
     
     
  • APR 19, 2022 | 12:00 PM
    Advances in Targeted Sequencing: Accelerate Your NGS Workflows with New QIAseq Chemistry
    Advances in Targeted Sequencing: Accelerate Your NGS Workflows...
    Targeted sequencing has many applications in cancer biomarker research, carrier screening and inherited disorders, drug development, mitochondrial DNA variant detection, human ID and paterni...
    Speaker: Krishna Amin
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: QIAGEN
    1
    MAR 22, 2022 | 7:00 AM
    Spatio-temporal characterization and quantification of DNA replication events by molecular combing
    Spatio-temporal characterization and quantification of DNA replication...
    Date: March 22, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) DNA replication happens at the very early stage of cell development, at such early stages of development...
    Speaker: Cyndie Forestier
    Sponsored By: Genomic Vision
    7
    FEB 23, 2022 | 11:55 PM
    Identification of Novel Protein Biomarkers in the Era of Precision Medicine Oncology
    Identification of Novel Protein Biomarkers in the Era of Precision...
    Cancer is a leading cause of morbidity and mortality in developed countries including the United States. Early detection of various cancers, before they spread and become incurable, has been...
    Speaker: Hilal Arnouk, MD, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2022
    3
    FEB 23, 2022 | 11:55 PM
    Next Generation Biobanking of Patient-derived Organoid Models
    Next Generation Biobanking of Patient-derived Organoid Models
    Princess Margaret Living Biobank (PMLB) is a repository for patient-derived organoid models. PMLB has generated over200 organoid models from lung, pancreas, colon, ovary, esophageal and brea...
    Speaker: Nikolina Radulovich, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2022
    1
    FEB 23, 2022 | 1:30 PM
    Innovative Approaches to Biomarker Discovery in the Drug Development Process
    Innovative Approaches to Biomarker Discovery in the Drug Development...
    High-throughput sequencing technology such as RNASeq and whole genome sequencing has enabled deep characterization of health and disease states. Biomarker discovery by these means has only h...
    Speaker: Esperanza Anguiano, PhD, MS-MBA
    Presented at: Drug Discovery & Development Virtual Event Series 2022
    Sponsored By: NanoString Technologies
    2
     
     
  • FEB 23, 2022 | 6:00 AM
    Autoantibodies as Biomarkers in Immuno-oncology
    Autoantibodies as Biomarkers in Immuno-oncology
    Cancer still accounts for nearly 1 in every 4 deaths worldwide. New immunotherapies have the power to induce durable responses in patients with fatal cancers, but only a small percentage of...
    Speaker: Hans-Dieter Zucht, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2022
    Sponsored By: Luminex - A DiaSorin Company
    10
    JAN 20, 2022 | 8:00 AM
    Modernization of tissue-based, biomarker-led clinical research
    Modernization of tissue-based, biomarker-led clinical research
    Date: January 20, 2021 Time: 08:00am (PST), 11:00am (EST) Automated staining platforms and digital slide scanners have revolutionized tissue-based biomarker research by providing a powerful...
    Speaker: Dr Stephanie Craig
    Sponsored By: Leica Biosystems
    15 1
    DEC 01, 2021 | 7:00 AM
    Using multiplex immunofluorescence to predict clinical outcomes in solid tumor cancer
    Using multiplex immunofluorescence to predict clinical outcomes...
    Date: December 01, 2021 Time: 7:00am (PST), 10:00am (EST) In the era of immuno-oncology, there is a growing need for the identification of new biomarkers predictive for sensitivity to anti-P...
    Speaker: Alban BESSEDE
    Sponsored By: Akoya Biosciences
    10 1
    OCT 14, 2021 | 9:00 AM
    Session 3: Simple steps to publication-quality western blots
    Session 3: Simple steps to publication-quality western blots
    Date: October 14, 2021 Time: 9:00am (PDT), 12:00pm (EDT), 5:00pm GMT Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring spe...
    Speaker: Kelli Feather-Henigan
    Presented at: Webinar series: Simple steps to publication-quality western blots
    Sponsored By: Thermo Fisher Scientific
    28
    OCT 13, 2021 | 7:00 AM
    Session 2: Simple steps to publication-quality western blots
    Session 2: Simple steps to publication-quality western blots
    Date: October 13, 2021 Time: 7:00am (PDT), 10:00am (EDT) Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring specific target...
    Speaker: Caleb Shearrow
    Presented at: Webinar series: Simple steps to publication-quality western blots
    Sponsored By: Thermo Fisher Scientific
    31 1
     
     
  • OCT 07, 2021 | 12:00 PM
    Panel Presentation: Oncology Variant Interpretation Just Got More Precise
    Panel Presentation: Oncology Variant Interpretation Just Got More...
    Across oncology applications, from research to molecular testing and pharmaceutical development, the ability to identify potentially actionable genetic alterations and exploit the molecular...
    Speaker: Beate Litzenburger, Ph.D. , Sheryl Elkin, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
    Sponsored By: QIAGEN
    2
    SEP 29, 2021 | 10:00 AM
    Study design: How and when to use multiplexed immunofluorescence imaging in your research
    Study design: How and when to use multiplexed immunofluorescence...
    Date: September 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Multiplexed tissue analysis is a powerful technique that allows comparisons of cell-type locations and cell-type interactions withi...
    Speaker: Melinda Angus-Hill Ph.D.
    Sponsored By: Leica Microsystems
    5
    SEP 28, 2021 | 9:00 AM
    New method for standardized, high-throughput PBMC isolation from blood samples for observational and clinical studies
    New method for standardized, high-throughput PBMC isolation from...
    Date: September 28, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Standardization and reproducibility are prerequisites for peripheral blood mononuclear cell (PBMC) generation from donor or patient...
    Speaker: Lotta Raty , Dr. Steffen Rapp , PhD
    Sponsored By: Miltenyi Biotec
    10 1
    SEP 14, 2021 | 7:00 AM
    What prevents you from increasing your PCR productivity?
    What prevents you from increasing your PCR productivity?
    Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
    Speaker: Arora Phang, PhD
    Sponsored By: Eppendorf
    24 1
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