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Glycan Release
Glycans, also known as polysaccharides, are carbohydrate-containing polymers that support functions like cellular structure and energy storage. Glycans are located on proteins but can be released via facilitation with an enzyme called peptide-N-glycosidase F (GNGase F). Glycans are released into the extracellular environment of the cell where they facilitate communication with other cells. Glycan release allows cells to obtain signals to alter their microenvironment when needed to support the cell.
SEP 22, 2020 | 10:00 AM
Monoclonal antibodies are heterogeneous molecules that include glycosylation variants, carboxyl truncation, and deamidation that require extensive analytical characterization. These molecule...
SEP 22, 2020 | 9:15 AM
This talk will explore HILIC chromatography methods for the analysis of released N-glycans labeled with InstantPC or 2-AB dyes. Best practices for robust methods will be introduced. Method d...
MAR 24, 2017 | 7:30 AM
DATE: March 24th, 2017TIME: 7:30AM PT, 10:30AM ET There is a growing demand in the biopharmaceutical industry for rapid N-glycosylation profiling of therapeutic antibodies....