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Microsatellite Instability (MSI)
Often caused by mistakes that are left uncorrected when DNA has been copied in a cell, microsatellite instability (MSI) is a condition that occurs in a certain type of cell, such as a cancer cell, where regions of the repeated DNA alter in length, showing instability due to a defect in mismatch repair DNA proteins. Since the errors go uncorrected, they accumulate and through DNA replication, the sequences are not preserved, ultimately creating new microsatellites.
OCT 08, 2020 | 10:00 AM
DATE: October 8, 2020 TIME: 1:00pm PDT Microsatellite instability (MSI) has evolved as a marker of potential hereditary cancer risk and is now a tissue agnostic immune biomarker with a broad...
JUL 02, 2020 | 12:15 PM
Microsatellite instability (MSI) is a hypermutation phenotype that results from impaired DNA mismatch repair (MMR). The presence of high levels of MSI (MSI-H) is potentially predictive of Ly...
MAY 08, 2020 | 8:00 AM
DATE: May 8, 2020 TIME: 8:00am PT, 11:00am ET Microsatellite instability (MSI) is the condition of genetic hypermutability that results from impaired DNA mismatch repair (MMR). Studies indic...
OCT 10, 2019 | 12:00 PM
Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...
JUN 20, 2019 | 10:30 AM
Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...
JUN 20, 2019 | 10:30 AM
Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...