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    Protein Binding

    Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.

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    FEB 11, 2022
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    FEB 05, 2022
    Health & Medicine
    What Is Stealth Omicron and What Might It Mean for the Pandemic?
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    Stealth Omicron, also known as the BA.2 subvariant, is considered sibling to Omicron's BA.1 variant that swept ...
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    Neuroscience
    How Iron Accumulation Leads to Age-related Cognitive Decline
    FEB 03, 2022
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    As we age, regulatory mechanics responsible for iron homeostasis in the brain break down, which leads to an iron-build u ...
    Written By: Annie Lennon
    JAN 20, 2022
    Cannabis Sciences
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    JAN 20, 2022
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    Written By: Nadine Husami
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