Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
-
DEC 01, 2020Cell & Molecular Biology
DEC 01, 2020The genome has instructions for creating and maintaining an organism, but most biological functions involve their transl ...WRITTEN BY: Carmen LeitchNOV 28, 2020Microbiology
NOV 28, 2020A mosquito-borne virus called VEEV has been emerging in South America. It causes symptoms that make it difficult to dist ...WRITTEN BY: Carmen LeitchNOV 26, 2020Drug Discovery & Development
NOV 26, 2020Reduced food intake, known as dietary restriction, leads to a longer lifespan in many animals and can improve health in ...WRITTEN BY: Nouran AminNOV 23, 2020Cell & Molecular Biology
NOV 23, 2020If a key isn't cut quite right, it might need a special jiggle to get it into a lock in the right way. Scientists have n ...WRITTEN BY: Carmen LeitchNOV 23, 2020Genetics & Genomics
NOV 23, 2020Clinicians have identified a patient with a rare inherited disorder that disrupts the production of fresh blood cells, a ...WRITTEN BY: Carmen LeitchNOV 23, 2020Microbiology
NOV 23, 2020The pathogenic bacterium that causes tuberculosis, Mycobacterium tuberculosis, does not multiply quickly, so researchers ...WRITTEN BY: Carmen LeitchNOV 23, 2020Drug Discovery & Development
NOV 23, 2020Therapeutically relevant ion channels have inspired researchers to look into drugs that can regulate their activity. Ion ...WRITTEN BY: Nouran AminNOV 22, 2020Microbiology
NOV 22, 2020Rotaviruses are the biggest reason why young children get diarrhea. It's estimated that 215,000 kids die every year from ...WRITTEN BY: Carmen LeitchNOV 22, 2020Cell & Molecular Biology
NOV 22, 2020ChIP-Seq is a tool for analyzing the interactions between DNA and the proteins that bind to it, which influences gene ac ...WRITTEN BY: Carmen LeitchNOV 18, 2020Drug Discovery & Development
NOV 18, 2020At the present moment, there are no inhibitors that target protease activity of the novel SARS-CoV-2. The main proteases ...WRITTEN BY: Nouran AminNOV 12, 2020Technology
NOV 12, 2020Researchers have recently developed a unique virtual reality (VR) tool that can help in drug development? Particularly, ...WRITTEN BY: Nouran AminNOV 12, 2020Cardiology
NOV 12, 2020Cardiovascular disease is something that, in most cases, is within our ability to control. A healthy diet and active lif ...WRITTEN BY: Jasper CantrellNOV 09, 2020Microbiology
NOV 09, 2020Camelids, which include llamas, alpacas and camels have immune systems that generate two kinds of antibodies when confro ...WRITTEN BY: Carmen LeitchNOV 06, 2020Immunology
NOV 06, 2020The virus that causes COVID-19, SARS-CoV-2, uses its spike protein to gain access to cells, by binding to the ACE2 recep ...WRITTEN BY: Tara FernandezNOV 04, 2020Cancer
NOV 04, 2020For decades, modern medicine has relied on chemists’ work to produce compounds that could one day be used as a dru ...WRITTEN BY: Jasper CantrellNOV 02, 2020Cell & Molecular Biology
NOV 02, 2020Cells have to be flexible and move with each other and our bodies. When cells get overstretched, they have to be able to ...WRITTEN BY: Carmen LeitchNOV 01, 2020Microbiology
NOV 01, 2020SARS-CoV-2, which causes COVID-19 has to get into cells to cause infection. It does so with a spike protein on its surfa ...WRITTEN BY: Carmen LeitchOCT 28, 2020Cancer
OCT 28, 2020Radiotherapy alone or with chemotherapy is the go-to treatment for head and neck cancers. Unfortunately, head and neck t ...WRITTEN BY: Jasper CantrellOCT 26, 2020Cancer
OCT 26, 2020Researchers from the Max Planck Institute of Biochemistry have developed a new approach to targeting leukemic stem cells ...WRITTEN BY: Kathryn DeMuth SullivanOCT 25, 2020Cell & Molecular Biology
OCT 25, 2020Ewing sarcoma is a rare kind of cancer that tends to impact young people and occurs in bones or the tissue around them. ...WRITTEN BY: Carmen LeitchOCT 24, 2020Immunology
OCT 24, 2020A team of researchers at Duke University have developed an imaging technology for tagging structures at a cellular level ...WRITTEN BY: Tara FernandezOCT 22, 2020Microbiology
OCT 22, 2020Since the pandemic virus SARS-CoV-2 emerged on the scene late last year, it's left a trail of devastation around the glo ...WRITTEN BY: Carmen LeitchOCT 21, 2020Microbiology
OCT 21, 2020Ebola virus can pass from animals to humans, and between people. Rarely, it causes outbreaks but when it does, they can ...WRITTEN BY: Carmen LeitchOCT 19, 2020Cancer
OCT 19, 2020Cancer is a disease characterized by DNA mutations. These mutations, while sometimes small, can cause havoc in a cell&rs ...WRITTEN BY: Jasper Cantrell
DEC 01, 2020
Cell & Molecular Biology
DEC 01, 2020
The genome has instructions for creating and maintaining an organism, but most biological functions involve their transl
...
WRITTEN BY:
Carmen Leitch
NOV 28, 2020
Microbiology
NOV 28, 2020
A mosquito-borne virus called VEEV has been emerging in South America. It causes symptoms that make it difficult to dist
...
WRITTEN BY:
Carmen Leitch
NOV 26, 2020
Drug Discovery & Development
NOV 26, 2020
Reduced food intake, known as dietary restriction, leads to a longer lifespan in many animals and can improve health in
...
WRITTEN BY:
Nouran Amin
NOV 23, 2020
Cell & Molecular Biology
NOV 23, 2020
If a key isn't cut quite right, it might need a special jiggle to get it into a lock in the right way. Scientists have n
...
WRITTEN BY:
Carmen Leitch
NOV 23, 2020
Genetics & Genomics
NOV 23, 2020
Clinicians have identified a patient with a rare inherited disorder that disrupts the production of fresh blood cells, a
...
WRITTEN BY:
Carmen Leitch
NOV 23, 2020
Microbiology
NOV 23, 2020
The pathogenic bacterium that causes tuberculosis, Mycobacterium tuberculosis, does not multiply quickly, so researchers
...
WRITTEN BY:
Carmen Leitch
NOV 23, 2020
Drug Discovery & Development
NOV 23, 2020
Therapeutically relevant ion channels have inspired researchers to look into drugs that can regulate their activity. Ion
...
WRITTEN BY:
Nouran Amin
NOV 22, 2020
Microbiology
NOV 22, 2020
Rotaviruses are the biggest reason why young children get diarrhea. It's estimated that 215,000 kids die every year from
...
WRITTEN BY:
Carmen Leitch
NOV 22, 2020
Cell & Molecular Biology
NOV 22, 2020
ChIP-Seq is a tool for analyzing the interactions between DNA and the proteins that bind to it, which influences gene ac
...
WRITTEN BY:
Carmen Leitch
NOV 18, 2020
Drug Discovery & Development
NOV 18, 2020
At the present moment, there are no inhibitors that target protease activity of the novel SARS-CoV-2. The main proteases
...
WRITTEN BY:
Nouran Amin
NOV 12, 2020
Technology
NOV 12, 2020
Researchers have recently developed a unique virtual reality (VR) tool that can help in drug development? Particularly,
...
WRITTEN BY:
Nouran Amin
NOV 12, 2020
Cardiology
NOV 12, 2020
Cardiovascular disease is something that, in most cases, is within our ability to control. A healthy diet and active lif
...
WRITTEN BY:
Jasper Cantrell
NOV 09, 2020
Microbiology
NOV 09, 2020
Camelids, which include llamas, alpacas and camels have immune systems that generate two kinds of antibodies when confro
...
WRITTEN BY:
Carmen Leitch
NOV 06, 2020
Immunology
NOV 06, 2020
The virus that causes COVID-19, SARS-CoV-2, uses its spike protein to gain access to cells, by binding to the ACE2 recep
...
WRITTEN BY:
Tara Fernandez
NOV 04, 2020
Cancer
NOV 04, 2020
For decades, modern medicine has relied on chemists’ work to produce compounds that could one day be used as a dru
...
WRITTEN BY:
Jasper Cantrell
NOV 02, 2020
Cell & Molecular Biology
NOV 02, 2020
Cells have to be flexible and move with each other and our bodies. When cells get overstretched, they have to be able to
...
WRITTEN BY:
Carmen Leitch
NOV 01, 2020
Microbiology
NOV 01, 2020
SARS-CoV-2, which causes COVID-19 has to get into cells to cause infection. It does so with a spike protein on its surfa
...
WRITTEN BY:
Carmen Leitch
OCT 28, 2020
Cancer
OCT 28, 2020
Radiotherapy alone or with chemotherapy is the go-to treatment for head and neck cancers. Unfortunately, head and neck t
...
WRITTEN BY:
Jasper Cantrell
OCT 26, 2020
Cancer
OCT 26, 2020
Researchers from the Max Planck Institute of Biochemistry have developed a new approach to targeting leukemic stem cells
...
WRITTEN BY:
Kathryn DeMuth Sullivan
OCT 25, 2020
Cell & Molecular Biology
OCT 25, 2020
Ewing sarcoma is a rare kind of cancer that tends to impact young people and occurs in bones or the tissue around them.
...
WRITTEN BY:
Carmen Leitch
OCT 24, 2020
Immunology
OCT 24, 2020
A team of researchers at Duke University have developed an imaging technology for tagging structures at a cellular level
...
WRITTEN BY:
Tara Fernandez
OCT 22, 2020
Microbiology
OCT 22, 2020
Since the pandemic virus SARS-CoV-2 emerged on the scene late last year, it's left a trail of devastation around the glo
...
WRITTEN BY:
Carmen Leitch
OCT 21, 2020
Microbiology
OCT 21, 2020
Ebola virus can pass from animals to humans, and between people. Rarely, it causes outbreaks but when it does, they can
...
WRITTEN BY:
Carmen Leitch
OCT 19, 2020
Cancer
OCT 19, 2020
Cancer is a disease characterized by DNA mutations. These mutations, while sometimes small, can cause havoc in a cell&rs
...
WRITTEN BY:
Jasper Cantrell
- Cell
- Protein
- Research
- University
- Disease
- Research and Development
- Publishing
- Cancer
- Gene
- Health
- Headache
- Sleep
- Sleep Medicine
- Locomotion
- Teeth
- Molecular Genetics
- Medicinal Marijuana
- CB1 Receptor
- Cannabidiol
- Crystal Structure
- CB2 Receptor
- Medical Marijuana
- Protein Structure
- Cannabidiol (CBD)
- Phytochemistry
- Science
- Biology
- T-Cells
- Reproductiive Health
- Drug Development
- Clinical Medicine
- Cell Biology
- Wellness
- Functional Medicine
- Molecular Biology
- Sequencing
- Endocannabinoid System
- Therapy
- Protein Biochemistry
- Human Genetics
- Cannabinoid Research
- Mood
- Fat
- Laboratory
- Suicide
- Sleep Disorders
- Jupiter
- Technology
- GABA Receptors
- Zebrafish
- Endocannabinoids
- Biochemistry
- Immunology
- Medicine
- Webinars
- Nerve
- Surface Coating
- Cancer Cell
- Microbiology
- Protein Engineering
- Stem Cells
- Tumor
- Engineering
- Animals
- Immunity
- Stem Cell Research
- Neuropharmacology
- Platelet
- Molecular Microbiology
- Clinical Genetics
- Human Biology
- Animal Research
- Genetics
- Clinical Research
- Molecular Techniques
- Cancer Research
- Protein Chemistry
- Protein Interaction
- Structural Biology
- Systems Biology
- Cancer Biology
- Microglia
- Helicobacter pylori
- RNA
- Neurochemistry
- Calcification
- Inhalation
- Histocompatibility
- Lupus
- Gene Regulation
- Protein Expression
- Screening
- DNA-Binding Proteins
- DNA
- Small Molecule
- Laboratory Medicine
- Mammals
- Biomarkers
- Brain
- Clinical Biochemistry
- Biologics
- Cell Imaging
- Cellular Mechanism
- Chemistry
- Pathology
- Biophysics
- Immune System
- Cannabinoids
- Genomics
- Muscle
- Gene Silencing
- Stem Cell
- Data Science
- Medical Cannabis
- One Health
- Therapeutics
- Single Cell
- Pollution
- Eating Disorders
- GMO
- Migraine
- Neurovascular
- Musculoskeletal
- Photoreceptors
- Clinical Genetic Molecular Biologist Scientist (CGMBS)
- Bleeding
- Experiment
- Calcium Imaging
- Molecular Immunology
- Long non-coding RNAs (lncRNAs)
- Neurodegeneration
- Mouse
- Antibodies
- Molecular Imaging
- Synapses
- Translational Research
- T Cell
- CAR T-Cells
- Transcription Factor
- Cell Line Development
- Developmental Biology
- Cell Signaling
- Cannabis Medicine
- Biomedical Research
- Microscopy
- Nanoparticles
- Molecular Modelling
- Medical Microbiology
- Infectious Disease
- Bacteria
- Life Sciences
- Medical Genetics
- Bone Biology
- Molecular Neuroscience
- Clinical Laboratory
- Gene Expression
- Transcription Factors
- Protein Characterization
- Insulin
- Sensory Systems
- Stem Cell Technologies
- Spectrometry
- Drug Discovery
- Transcriptional Regulation
- Stroke
- Mental Health
- Multiple Sclerosis
- Cardiac Markers
- Bioinformatics
- Imaging
- High Throughput Screening
- Fertility
- Neurodevelopmental Disorders
- DNA Damage
- Disease Modeling
- Brain Health
- Cell Therapy
- Clinical Lab
- Preventative Medicine
- Neuron
- Toxin
- Lymphocytes
- Molecular Pathology
- Metabolomics
- Health Technology
- Neurotransmitters
- Molecular Pharmacology
- Meiosis
- Bones
- Pain
- Cannabis
- Bioprocess
- Bioprocess Technology
- Control System
- Depression
- Synapse
- Digestion
- Bird
- Medical Technology
- Personality
- Neurons
- Toxicology
- Cannabis Sciences
- Brain Stimulation
- Microfluidics
- Inflammation
- Virus
- Protein Digestion
- Assay Development
- Autoimmune Disease
- Genetic Engineering
- Immunotherapeutics
- Process Chemistry
- Medical Laboratory
- Functional Genomics
- Bone Development
- Communication
- Microbiome
- Anemia
- Emotion
- Sepsis
- Staphylococcus
- Mutation
- Blood
- Structural Bioinformatics
- Infection
- Diagnostics
- Environment
- Neurodegenerative Disease
- Drug Design
- Bone Marrow
- Biomaterials
- Chemical Biology
- Bone Diseases
- Bacteriology
- Host Cell Protein
- Neurobiology
- Vaccinations
- Cancer Genomics
- Lipid
- Vaccine Research
- Photonics
- Agricultural Biology
- Pathogenic Bacteriology
- Neuropsychology
- Behavior
- Computational Biology
- Behavioral Research
- Agricultural Sciences
- Neuroscience
- Proliferation
- Innate Immune System
- Disease Prevention
- Molecular Biophysics
- Clinical Trials
- Cardiology
- Microtubules
- Pathogen
- Life Science
- Preventive Medicine
- Animal Models
- Cancer Therapeutics
- Molecular Diagnostics
- Pharmacology
- ALS
- Sequence Analysis
- Cancer Treatment
- Brain Diseases
- Inflammatory Disease
- Dopamine
- Neural Plasticity
- Complex Disease
- Treatment of Cancer
- Biotechnology
- Clinical Diagnostics
- Viral Vectors
- Mitochondria
- Multiple Sclerosis (MS)
- Mammal
- Targeted Therapy
- Biomedical Sciences
- Case Study
- Clinical Chemistry
- Cancer Metabolism
- Cell Differentiation
- Coding
- Genetic Testing
- Atomic Physics
- Heart Disease
- Adrenergic Receptors
- Pre-clinical Research
- Acetylcholine Receptor
- Muscular Dystrophy
- Data Analysis
- Cancer Immunology
- Cancer Stem Cells
- Cell Based Assays
- Lab Testing
- Spectroscopy
- Aerobiology
- Micro RNA
- Animal Production
- Endothelial Cells
- Motor Control
- Movement Disorders
- Cell Culture
- Pharmaceutical
- Scaffold
- Tissue Regeneration
- Nanoparticle
- Gene Therapy
- Pharmaceuticals
- Interventional cardiology
- Mechanics
- Lipids
- General Laboratory
- Parkinson's
- High Throughput
- Cardiovascular Research
- Fish
- Sickle Cell Anemia
- GABA
- Antibody-Based Protein
- Biofuels
- Clinical Microbiology
- Cartilage
- Caenorhabditis Elegans
- Snakes
- Graphene
- Telomerase
- Anthropology
- Coronavirus
- Hypoxic-ischemic
- Archaeology
- Nanoscience
- Frontotemporal Lobar Degeneration (FTLD)
- Platelets
- Molecular Neurobiology
- Zoology
- Cultural Studies
- Skin
- Laboratory Testing
- GPCR
- Autoimmunity
- Enhancer
- Visualization
- Microvesicles
- Cell Death
- Protein Microarray
- Macrophage
- Cognitive Neuroscience
- Oxidative Stress
- Fluorescence
- Genomic Testing
- Pre-Clinical
- Tumor Markers
- Physical Testing
- Cell Surface Receptors
- Microprobe
- Clinical Neuroscience
- Bone Metabolism
- Chromatin
- Clinical Ethics
- Mammalogy
- Red Blood Cells
- Glioma
- Metabolism
- Fibroblast
- Fluorescence Microscopy
- Cognition
- Immunotherapy
- Neuroplasticity
- Genome Editing
- Lung Cancer
- Stem Cell Therapy
- Regeneration
- T-cell Receptor
- Chronic Disease
- Virology
- Microarray Analysis & Technology
- Adipose Tissue
- Biomechanics
- Epilepsy
- Oxygen
- Cell Isolation
- Space
- Calcium
- Clinical Pharmacology
- Tissue Engineering
- Natural Medicine
- Diet
- Functional Assays
- Tolerance
- Education
- Laboratory Methods
- Prescription Drugs
- Telomere
- Human Papillomavirus HPV
- Cancer Diagnostics
- Oncology
- Public Health
- Innovation
- Open Science
- Color Science
- Cancer Cell Culture
- Down Syndrome
- Molecular Psychology
- Pharmaceutical Testing
- Diagnosis
- Chromosome
- Molecular Magnetism
- microRNA
- Complex Systems
- Evolution
- Medical Imaging
- Brain Damage
- Enzyme
- Heart Failure
- Vision
- Hormone
- Neuronal Differentiation
- General Medicine
- Central Nervous System (CNS)
- Angiogenesis
- Pain Medication
- Tumor Targeting
- Blood Cancer
- Crystallography
- Science Education
- Solution
- Chronic Pain
- Personalized Medicine
- Cancer Prevention
- Cancer Biomarker
- Injury
- Blood Brain Barrier
- Psychiatric Disorders
- Troponin
- Infusion
- Cerebellum
- Embryonic Stem Cells
- Spine
- Fragile X Syndrome
- Tissue Culture
- Antibiotics
- Information Technology
- Cell Adhesion
- Gene Sequencing
- Prostate Cancer
- Behavior Sciences
- Cannabis Testing
- Fly
- Dementia
- Behavioral Neuroscience
- Tumor Angiogenesis
- Digestive Enzymes
- Vaccination
- Animal Diets
- Carrier Protein
- Physics
- Physiology
- Primary Cells
- Synthetic Biology
- Autism
- Clinical Psychology
- Flavor
- Validation
- In Vivo
- Metastasis
- Long non-coding RNAs
- Drug Abuse
- Sun
- Kidney
- Antidepressants
- Radiation
- Information System
- Animal Sciences
- Biomedical Engineering
- DNA Sequencing
- Single Cell Organism
- Computer Science
- Large Molecule
- Cognitive Research
- Single-Molecule
- Vaccine
- Bioengineering
- Immunogenicity
- Healthy Ageing
- Bacteria Resistant
- Clinical Oncology
- Cellular Pathology
- Obesity
- Stem Cell Culture
- Clinical Toxicology
- Cellular Differentiation
- DNA Repair
- Fishing
- Medical Laboratory Scientist
- Drug Resistance
- Arthritis