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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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If we want to prevent viral infections or develop drugs that can effectively treat them, those infections have to be inv ...Written By: Carmen LeitchMAY 25, 2025Microbiology
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JUN 25, 2025
Cell & Molecular Biology
If we want to prevent viral infections or develop drugs that can effectively treat them, those infections have to be inv
...
Written By:
Carmen Leitch
MAY 25, 2025
Microbiology
Trillions of microbes live in the human gastrointestinal tract, where they play critical roles in our health and biology
...
Written By:
Carmen Leitch
FEB 23, 2025
Cell & Molecular Biology
Researchers have identified a compound in ginger that could treat some symotoms of inflammatory bowel disease.
Written By:
Carmen Leitch
FEB 17, 2025
Cell & Molecular Biology
The microbes in the human gastrointestinal tract can have a significant influence on human health and disease, and this
...
Written By:
Carmen Leitch
JAN 29, 2025
Cell & Molecular Biology
The endoplasmic reticulum (ER) is a crucial organelle present in all eukaryotic cells, including human cells. The ER pla
...
Written By:
Carmen Leitch
JAN 28, 2025
Genetics & Genomics
Transcription factors are proteins that can bind to DNA and affect the expression of genes; some are known as master reg
...
Written By:
Carmen Leitch
NOV 25, 2024
Genetics & Genomics
Scientists have identified a cellular mechanism that cells use to repair damage in DNA that is associated with aging & h
...
Written By:
Carmen Leitch
NOV 04, 2024
Genetics & Genomics
In cells, there is a careful coordination of activity among molecules. Genes have to be expressed in the right cells at
...
Written By:
Carmen Leitch
NOV 04, 2024
Cell & Molecular Biology
Apoptosis is a process in which cells die off, intentionally. This programmed cell death helps eliminate billions of cel
...
Written By:
Carmen Leitch
SEP 15, 2024
Cell & Molecular Biology
A sea star oocyte that has been treated with a fluorescent marker of the novel system in shown in this image by D. Nath
...
Written By:
Carmen Leitch
JUL 29, 2024
Microbiology
The H5N1 avian influenza is highly pathogenic and has been devastating bird populations worldwide. It continues to
...
Written By:
Carmen Leitch
JUL 10, 2024
Microbiology
When our body is attacked by a pathogen, the pathogen has to find ways to evade our immune system and invade our cells t
...
Written By:
Carmen Leitch
MAY 16, 2024
Cell & Molecular Biology
Proteins are often studied at very low temperatures. In the case of cryo-electron microscopy, for example, proteins are
...
Written By:
Carmen Leitch
MAR 08, 2024
Immunology
Barcoding technologies that take advantage of the high information content that can be encoded in oligonucleotide sequen
...
Sponsored By:
Quantum-Si
FEB 21, 2024
Cancer
Last August, Labroots covered the decision of the National Health Service of England (NHS England) to allow subcu
...
Written By:
Katie Kokolus
FEB 15, 2024
Drug Discovery & Development
Research unveiling cresomycin, a novel antibiotic combating drug-resistant bacteria by targeting bacterial protein synth
...
Written By:
Amielle Moreno
FEB 08, 2024
Cell & Molecular Biology
For many years, rates of sexually transmitted infections (STIs) were getting lower, but that trend has reversed in recen
...
Written By:
Carmen Leitch
FEB 05, 2024
Cell & Molecular Biology
Viruses need host cells, and pathogens have many different ways to infect them. Scientists have revealed a rapid movemen
...
Written By:
Carmen Leitch
FEB 05, 2024
Immunology
Introduction Proteins are essential molecules in the human body that construct the building blocks of life. Long chains
...
Sponsored By:
MilliporeSigma
FEB 02, 2024
Genetics & Genomics
Millions of people have autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis but it's estim
...
Written By:
Carmen Leitch
JAN 25, 2024
Immunology
Chemotherapy has long been the gold standard for cancer treatment since its inception in the 1950s. Chemotherapy is a tr
...
Written By:
Brian G. Morreale
JAN 25, 2024
Drug Discovery & Development
Developing new pharmaceuticals is a complex and costly process that requires innovation and efficiency. High-throughput
...
JAN 18, 2024
Immunology
Different pathways within the cell are activated or silenced dependent on the external signals acting on a cell. One suc
...
Written By:
Brian G. Morreale
JAN 15, 2024
Microbiology
Some bacterial cells can prey on others, and launch attacks on target cells. So without eyes, ears, or a brain, how do t
...
Written By:
Carmen Leitch