Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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MAR 25, 2019
Cell & Molecular Biology
MAR 25, 2019
Honeybee queen larvae are held in a specific orientation using protein rich "royal jelly" that directs their development into the Queen Bee....
Written By:
Carly Boyd
MAR 18, 2019
Health & Medicine
MAR 18, 2019
Scientists uncover new "viral oncogenes" that allow HPV to turn healthy cells into cancer cells, while evading the immune system....
Written By:
Carly Boyd
MAR 14, 2019
Technology
MAR 14, 2019
Certain mammals, including humans, can see a limited range of wavelengths of light known as visible light. The visible light spectrum includes the waveleng...
Written By:
Nouran Amin
FEB 28, 2019
Cannabis Sciences
FEB 28, 2019
Scientists from the University of California, Berkeley, have been able to extract cannabis compounds not from the cannabis plant, but from yeast grown...
Written By:
Amy Loriaux
FEB 26, 2019
Genetics & Genomics
FEB 26, 2019
Estimates vary but there are around 20,000 proteins that encode for protein in the human genome. So what's the rest for?...
Written By:
Carmen Leitch
FEB 21, 2019
Cell & Molecular Biology
FEB 21, 2019
If a species wants to survive, genetic information has to be passed successfully from one generation to the next....
Written By:
Carmen Leitch
FEB 14, 2019
Cell & Molecular Biology
FEB 14, 2019
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Written By:
Carmen Leitch
FEB 05, 2019
Genetics & Genomics
FEB 05, 2019
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FEB 05, 2019
Microbiology
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JAN 09, 2019
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Health & Medicine
JAN 06, 2019
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Cell & Molecular Biology
JAN 05, 2019
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JAN 03, 2019
Cannabis Sciences
JAN 03, 2019
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Written By:
Amy Loriaux
DEC 26, 2018
Immunology
DEC 26, 2018
A team from Scripps Research has found a molecular cause of a group of rare autoimmune disorders in which the immune system attacks the body's healthy cells....
Written By:
Nicholas Breehl
DEC 26, 2018
Genetics & Genomics
DEC 26, 2018
Scientists have long been seeking to understand aging. Researchers found age-related changes in cell-free DNA....
Written By:
Carmen Leitch
DEC 12, 2018
Immunology
DEC 12, 2018
A group of researchers describes the biophysical and structural characteristics of an immune regulating protein called human T cell immunoglobulin and mucin domain-containing protein-3 (hTIM-...
Written By:
Nicholas Breehl
DEC 11, 2018
Immunology
DEC 11, 2018
Research reveals a genetic mutation causes a protein binding site to alter its structure resulting in the development of chronic inflammation and autoimmunity...
Written By:
Nicholas Breehl
DEC 09, 2018
Cannabis Sciences
DEC 09, 2018
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Written By:
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NOV 20, 2018
Cell & Molecular Biology
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Written By:
Carmen Leitch
NOV 06, 2018
Cannabis Sciences
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NOV 02, 2018
Cell & Molecular Biology
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Written By:
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OCT 24, 2018
Drug Discovery
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Written By:
Nouran Amin
OCT 06, 2018
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Scientists at Stevens Institute of Technology have designed a new class of molecules that may hold the potential to add to the arsenal of drugs actively be...
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Nouran Amin
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