Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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FEB 17, 2020
Cell & Molecular Biology
FEB 17, 2020
Some individuals are morning people to the extreme. Some genetic mutations give the body clock a 20 instead of 24-hour cycle....
WRITTEN BY:
Carmen Leitch
FEB 10, 2020
Immunology
FEB 10, 2020
Scientists discovered a new mechanism by which cancer cells evade the immune system to further their own agenda: invade, multiply, and spread. Identifying...
WRITTEN BY:
Kara Marker
FEB 09, 2020
Cell & Molecular Biology
FEB 09, 2020
The X chromosome carries a thousand genes, so in females, one of the X chromosomes must be silenced to avoid serious developmental consequences....
WRITTEN BY:
Carmen Leitch
FEB 07, 2020
Clinical & Molecular DX
FEB 07, 2020
Intrinsic biophysical properties of proteins hold valuable clues about how they function and their role in disease. Take, for example, one of the most comm...
WRITTEN BY:
Tara Fernandez
JAN 23, 2020
Cancer
JAN 23, 2020
New research published in the journal Cancer Cell investigates the role of circular RNAs in the spread of melanoma. Melanoma is a particularly aggressive c...
WRITTEN BY:
Kathryn DeMuth Sullivan
JAN 17, 2020
Neuroscience
JAN 17, 2020
Approximately 1% of the world’s population have schizophrenia, with 3.2 million Americans having the disorder. Now, for the first time, advanced brai...
WRITTEN BY:
Annie Lennon
JAN 15, 2020
Cell & Molecular Biology
JAN 15, 2020
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Carmen Leitch
DEC 27, 2019
Genetics & Genomics
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Carmen Leitch
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Microbiology
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Carmen Leitch
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Drug Discovery & Development
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Technology
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Kara Marker
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Microbiology
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WRITTEN BY:
Carmen Leitch
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Chemistry & Physics
DEC 05, 2019
Cryonics ("Cryo" related to Greek word for "cold") is a highly controversial method to deep freeze and store a deceased human body, hop...
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Yin (Daniel) Duan
DEC 01, 2019
Cell & Molecular Biology
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Carmen Leitch
NOV 27, 2019
Immunology
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Human cells employ an intricate tagging system to manage protein activity in the body. By “tagging” a protein with a certain modification, cell...
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Kara Marker
NOV 26, 2019
Clinical & Molecular DX
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Cell & Molecular Biology
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Carmen Leitch
NOV 03, 2019
Cell & Molecular Biology
NOV 03, 2019
Molecules and drugs move among cells and bind to receptors on the cell surface, which can initiate a cascade of reactions....
WRITTEN BY:
Carmen Leitch
OCT 31, 2019
Cell & Molecular Biology
OCT 31, 2019
Researchers have known that proteins can insulate electrical flow, but their power as conductors has only recently been recognized....
WRITTEN BY:
Carmen Leitch
OCT 30, 2019
Genetics & Genomics
OCT 30, 2019
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Carmen Leitch
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