APR 25, 2019 7:45 PM PDT

Study Finds CBD Counters Effect of THC on Brain Connectivity

WRITTEN BY: Amy Loriaux

A recent study published in the Journal of Psychopharmacology, conducted by Dr. Matthew B. Wall and colleagues from Invicro London at Hammersmith Hospital in London, suggesting that cannabidiol (CBD) can counter the effect of delta-9-tetrahydrocannabinol (THC) on functional connectivity. This supports previous research that shows the counteracting effects of CBD on THC effects. CBDs have been suggested to counter the psychoactive properties of THC.

Photo sourcePixabay.com  

These results are important given the increase in the production of high-potency cannabis. In these strains, the level of CBD has been all but bred out. The increase in potency is due to the percentage of THC in the plant. In terms of public health, the prevalence of high-potency cannabis may be behind the increase in cases of marijuana-induced acute psychosis. CBD is generally thought to produce feelings of calm (as well as other health benefits) and this effect could be very beneficial in taming the high levels of THC in today's pot. The study described here has found another way that CBD counters THC's effects: changes in functional connectivity.

The functional connectivity of different areas of the brain is associated with different states of mind. There are a variety of "modes" or networks that are determined by which areas are concurrently active. The basic "state" is known as the "default mode", which occurs during periods of rest (not sleep, just...not doing much). Other modes are related to various mental states such as salience and executive function.  

To study the effects of THC and THC + CBD on functional brain activity, 17 study participants were given either cannabis with THC but no CBD (Cann-CBD; 8 mg THC), cannabis with both THC and CBD (Cann+CBD; 8 mg THC + 10 mg CBD); or placebo, and fMRI was performed to test the effects of 3 strains on 3 networks: default mode, executive control, and salience. Each of these networks centers around connectivity to various brain regions. The default mode is defined as positive connectivity with the posterior cingulate cortex; the executive control network is associated with negative connectivity with the posterior cingulate cortex, and the salience network is defined by positive connectivity with the anterior insula.

Photo source: UnSplash.com

The researchers found that the THC only group and the THC+CBD group had different patterns of activation. The THC only group had decreased connectivity in the salience network, compared to controls, which was rescued by the addition of CBD. The default mode was also disrupted in the THC only group, and this positively correlated with subjective feelings of being "high". These results add to the growing body of literature suggesting that CBD counteracts the effects of THC. So the next time you indulge (legally, please) you may want to have your CBD pen handy.

See the video below for a brief tutorial on the default mode network.

Video sourceYouTube

SourcesJournal of Psychopharmacology, LabRoots, European Journal of Pharmacology, Proceedings of the National Academy of Sciences (PNAS), Journal of Neuroscience

 

About the Author
  • I currently work at a small CRO involved in clinical trial management.
You May Also Like
JUL 20, 2020
Cannabis Sciences
How Does Cannabis Impact Memory?
JUL 20, 2020
How Does Cannabis Impact Memory?
How exactly cannabis affects our memory- and for how long, and how significantly- is still a subject for debate. With an ...
AUG 20, 2020
Health & Medicine
Does Recreational Marijuana Out-of-Hours Affect Work Performance?
AUG 20, 2020
Does Recreational Marijuana Out-of-Hours Affect Work Performance?
Imagine that after a busy day at work you kick back with a relaxing cannabis joint. In many states that is now entirely ...
SEP 01, 2020
Plants & Animals
Warsaw Zoo Testing CBD to Manage Elephants' Stress
SEP 01, 2020
Warsaw Zoo Testing CBD to Manage Elephants' Stress
Humans use cannabidiol (CBD) for its array of health benefits, and household pets even benefit from CBD treatments in sp ...
SEP 13, 2020
Cannabis Sciences
Public Perceive Legal Cannabis as Too Pricy
SEP 13, 2020
Public Perceive Legal Cannabis as Too Pricy
Researchers have found that over a third of people think legal cannabis is safer and of higher quality than that availab ...
OCT 14, 2020
Health & Medicine
Sanobiotec Produces Reliable THCV
OCT 14, 2020
Sanobiotec Produces Reliable THCV
Lithuania-based bio Sanobiotec has joined a band of biotech companies moving into the synthetic cannabinoid market and a ...
NOV 11, 2020
Health & Medicine
Who Gets Cannabis Use Disorder? A Risk Prediction model Could Find Out
NOV 11, 2020
Who Gets Cannabis Use Disorder? A Risk Prediction model Could Find Out
Along with the benefits of cannabis come some downsides. One of these is cannabis use disorder (CUD), which is predicted ...
Loading Comments...