OCT 13, 2020 5:09 PM PDT

Uses of Tandem Mass Spectrometry (TMS)

WRITTEN BY: Nouran Amin

What is tandem mass spectrometry? A powerful analytical tool that is capable of characterizing complex mixtures in drug discovery and other fields. Now, researchers are using tandem mass spectrometry to improve the flow of information when developing drugs.

"Mass spectrometry plays an integral role in drug discovery and development," said Gaurav Chopra, an assistant professor of analytical and physical chemistry in Purdue's College of Science. "The specific implementation of bootstrapped machine learning with a small amount of positive and negative training data presented here will pave the way for becoming mainstream in day-to-day activities of automating characterization of compounds by chemists."

Findings were published in the journal Chemical Science.

"We have addressed both of these items for a methodology that is isomer selective and extremely useful in chemical sciences to characterize complex mixtures, identify chemical reactions and drug metabolites, and in fields such as proteomics and metabolomics," Chopra said.

Learn more about mass spectrometry:

"This is the first time that machine learning has been coupled with diagnostic gas-phase ion-molecule reactions, and it is a very powerful combination, leading the way to completely automated mass spectrometric identification of organic compounds," said Hilkka Kenttämaa, the Frank Brown Distinguished Professor of Analytical Chemistry and Organic Chemistry. "We are now introducing many new reagents into this method."

Source: Science Daily

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
OCT 19, 2021
Microbiology
An Antibiotic May be Able to Reduce Inflammatory Pain
OCT 19, 2021
An Antibiotic May be Able to Reduce Inflammatory Pain
The gastrointestinal tract is full of microbes, all with their own genomes and characteristics. Some of those microbes a ...
OCT 29, 2021
Health & Medicine
The Happenstance Discovery of Delta 10 THC
OCT 29, 2021
The Happenstance Discovery of Delta 10 THC
The random discovery of Delta 10 is a good example of how cannabis science has only just begun to explore the complexity ...
NOV 01, 2021
Genetics & Genomics
Genetic Connnections to Osteoerthritis
NOV 01, 2021
Genetic Connnections to Osteoerthritis
Osteoarthritis is a painful condition in which joints become inflamed, leading them to feel stiff or sore, especially in ...
NOV 08, 2021
Coronavirus
Pfizer Claims Their New COVID-19 Pill Reduces Hospitalization Risk by 89%
NOV 08, 2021
Pfizer Claims Their New COVID-19 Pill Reduces Hospitalization Risk by 89%
Current treatments for COVID-19 have to be administered intravenously, so a pill that could treat patients would be huge ...
NOV 19, 2021
Cannabis Sciences
Topical CBD Reverses UV-Induced Changes in Skin
NOV 19, 2021
Topical CBD Reverses UV-Induced Changes in Skin
Results from a new study published in Nature’s Scientific Reports suggest that topical application of cannabidiol ...
NOV 23, 2021
Infographics
The Health Benefits of Cannabis
NOV 23, 2021
The Health Benefits of Cannabis
Legislation is opening more and more doors for cannabis- causing an explosion in both research and marketing campaigns f ...
Loading Comments...