Antiphospholipid syndrome (aPS) is a thrombotic disorder characterized by persistent venous and arterial thrombosis, potentially resulting in any symptoms related to those disorders, including balance and mobility, vision problems, speech and memory, tingling sensations, transient ischemic attack, rash, or repeated migraines. While the disorder can occur in both men and women, additional obstetric or gynecological manifestations can occur in women, including miscarriage, preeclampsia, and fetal growth delays. Antiphospholipid antibodies, including lupus anticoagulant assays run on automated coagulation platforms are one part of the panel of tests recommended to screen and diagnose aPS. As a member of the Scientific and Standardization Committee on lupus anticoagulants and antiphospholipid antibodies from the International Society on Thrombosis and Heamostasis, Dr Tom Ortel will present recent guideline updates and bring together relevant clinical research publications. The presentation will educate attendees and resolve any remaining confusion present in the greater scientific community.