MAR 19, 2015 10:30 AM PDT

Special Lecturer - In Vivo PET /SPECT Imaging of Human Brain Neuroreceptor Systems: 3 Decades of Progress

Presented at: Neuroscience
Speaker
  • Radiology Vice Chair for Research Administration and Training, Professor of Radiology and Radiological Science, Johns Hopkins University School of Medicine
    Biography
      Dr. Dean Foster Wong is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. He also serves as Radiology Vice Chair for Research Administration and Training, and Director of the Section of High Resolution Brain PET Imaging within the Division of Nuclear Medicine.
      <br />
      <br />Dr. Wong received his undergraduate degree in physics from the University of Western Ontario, and completed his M.D. at the University of Toronto in 1977. After an internship at Sunnybrook Medical Center in Toronto, he undertook a residency in anatomic pathology at Princess Margaret Hospital of the Ontario Cancer Institute, and a subsequent residency in radiology at the University of Toronto.
      <br />
      <br />In 1980, he came to Johns Hopkins as a research and clinical fellow in the Radiology Division of Nuclear Medicine. He was soon promoted to Assistant Professor of Radiology, and in 1987 became an Associate Professor. He received a doctorate in Radiation Health Sciences from Hopkins in 1990.
      <br />
      <br />Over the course of his career, Dr. Wong has been a leader in the design, development and use of PET scanning for the study of brain chemistry. He has been primary investigator on numerous federal and private grants, has authored or coauthored more than 200 articles and 50 book chapters and essays, and has been an active consultant to pharmaceutical companies.
      <br />
      <br />In 2013, the Society of Nuclear Medicine and Molecular Imaging bestowed upon him the Paul C. Aebersold Award for Outstanding Achievement in Basic Nuclear Medicine Science.
      <br />

    Abstract

    Since the discovery and maturing of in vitro techniques that characterized neurotransmitter receptor systems in animal and human brain and subsequent development of in vitro and in vivo autoradiography, there was always a clear scientific motivation to carry out these measurements in living brain. In the early 1980s, this was realized by both in vivo preclinical and ultimately human imaging of neurotransmitter (NT) systems starting with dopamine opiate and serotonin system. Now, some 30 years later, the in vivo imaging of (NT) receptor systems, primarily employing the methodology known as positron emission tomography (PET), single photon imaging computer tomography (SPECT) and other chemical measures including magnetic resonance spectroscopy (MRS) and pfMRI (pharmacologic magnetic resonance imaging) have dramatically established these approaches as valuable tools for neuroscience research.


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