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    Immune tolerance

    Immune tolerance, or immunotolerance, occurs when the immune response does not activate in response to an insult, such as a virus or infection. Normally, the immune response is activated when it encounters a foreign insult, known as an antigen. Immune tolerance can be beneficial in preventing an immune response against towards self-antigens located in the body which could result in autoimmune diseases.

    Webinars

    • SEP 08, 2022 | 12:00 PM
      Panel Presentation: RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral Pathogens, Including SARS-CoV-2
      Panel Presentation: RT-LAMP: Best Practices and Tips to Accelerate...
      Loop-mediated isothermal amplification (LAMP) uses a stand-displacing DNA polymerase and four to six primers to rapidly amplify DNA at a single temperature. By eliminating temperature cyclin...
      Speaker: Ingrida Vendelė, PhD , Leann Buhrow, PhD
      Presented at: Microbiology Week Virtual Event Series 2022
      Sponsored By: Thermo Fisher Scientific
      4
      JUL 12, 2022 | 8:00 AM
      Solutions for dendritic cell research
      Solutions for dendritic cell research
      Date: July 12, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CEST) Dendritic cells (DCs) are a heterogeneous population of myeloid immune cells that act as peripheral sentinels specializin...
      Speaker: Dr. Nizar Yousif
      Sponsored By: Miltenyi Biotec
      15
      APR 19, 2022 | 12:00 PM
      C.E. CREDITS
      RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral Pathogens, Including SARS-CoV-2
      RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral...
      Loop-mediated isothermal amplification (LAMP) uses a stand-displacing DNA polymerase and four to six primers to rapidly amplify DNA at a single temperature. By eliminating temperature cyclin...
      Speaker: Ingrida Vendelė, PhD , Leann Buhrow, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: Thermo Fisher Scientific
      3
      FEB 23, 2022 | 6:00 AM
      Autoantibodies as Biomarkers in Immuno-oncology
      Autoantibodies as Biomarkers in Immuno-oncology
      Cancer still accounts for nearly 1 in every 4 deaths worldwide. New immunotherapies have the power to induce durable responses in patients with fatal cancers, but only a small percentage of...
      Speaker: Hans-Dieter Zucht, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2022
      Sponsored By: Luminex - A DiaSorin Company
      10
      DEC 09, 2021 | 8:00 AM
      Reprogramming human regulatory T cell specificity with a novel anti-HLA-A2 chimeric antigen receptor
      Reprogramming human regulatory T cell specificity with a novel...
      Date: December 9, 2021 Time: 8:00am (PDT), 11:00am (EDT) Engineering human regulatory T cells (Tregs) with a chimeric antigen receptor (CAR) targeting donorderived human leukocyte antigen (H...
      Speaker: Leonardo Ferreira
      Sponsored By: Thermo Fisher Scientific/Gibco
      5
      NOV 30, 2021 | 7:00 AM
      A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
      A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
      Date: November 30, 2021 Time: 7:00am (PDT), 10:00am (EDT) Wastewater Surveillance programs for SARS-CoV-2 are being implemented by health authorities globally. Many laboratories are currentl...
      Speaker: Subhanjan Mondal , Carlotta Olivero
      Sponsored By: Promega
      8 1
      OCT 28, 2021 | 9:00 AM
      RT-LAMP: Best practices and tips to accelerate detection of viral pathogens, including SARS-CoV-2
      RT-LAMP: Best practices and tips to accelerate detection of viral...
      Date: October 28, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Loop-mediated isothermal amplification (LAMP) uses a stand-displacing DNA polymerase and four to six primers to rapidly amplify DNA a...
      Speaker: Ingrida Vendelė, PhD , Leann Buhrow, PhD
      Sponsored By: Thermo Fisher Scientific
      11
      JUN 09, 2021 | 8:00 AM
      Working with antigen-specific T cells
      Working with antigen-specific T cells
      DATE: June 9, 2021 TIME: 8:00am PDT Analyzing antigen-specific T cells is essential to understand fundamental immunological processes in the contexts of immuno-oncology, infectious dise...
      Speaker: Lorenz Fülle, PhD
      Sponsored By: Miltenyi Biotec
      10 3
      JUN 02, 2021 | 10:30 AM
      Keynote Presentation: New Checkpoints and Biomarkers
      Keynote Presentation: New Checkpoints and Biomarkers
      Learning Objectives: 1. Understand how the outcome of PD-1 blockade is a summation of increased Teffector activity and increased Treg suppressive activity 2. Explain how PD-1 blockade leads...
      Speaker: Gordon Freeman, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      2
      JUN 02, 2021 | 12:00 AM
      IDO in Melanoma..... Deserves Further Evaluation
      IDO in Melanoma..... Deserves Further Evaluation
      Learning Objectives: 1. Learn about IDO pathway 2. IDO rule in cancer...
      Speaker: Yousef Zakharia, MD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      1
      APR 21, 2021 | 12:00 AM
      Past, Present and Future of Engineered Cell Therapy
      Past, Present and Future of Engineered Cell Therapy
      Engineered cell therapy is an emerging field of science to target and treat cancer. Current strategies include utilizing immune cells such as T cells, NK cells and Macrophages or other cells...
      Speaker: Janani Krishnamurthy, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      2
      MAR 16, 2021 | 8:00 AM
      The latest developments for enriching and analyzing antigen- and virus-specific T cells
      The latest developments for enriching and analyzing antigen- and...
      DATE: March 09, 2021 TIME: 08:00am PST The COVID-19 pandemic has placed urgency on precise analysis of rare antigen- and virus-specific T cells. At Miltenyi Biotec, we offer a complete workf...
      Speaker: Lorenz Fülle, PhD
      Sponsored By: Miltenyi Biotec
      12
      FEB 10, 2021 | 12:00 AM
      Experimental design strategies in primate trials that embrace the clinical schema to enhance translation
      Experimental design strategies in primate trials that embrace...
      Primates have been essential in unlocking novel immune mechanisms that have driven development of groundbreaking new drugs in infectious disease and transplantation, amongst others related t...
      Speaker: Melanie L. Graham, MPH, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2021
      5
      JAN 27, 2021 | 9:00 AM
      Uterine B cell dynamics during pregnancy - Immune regulation of the placenta
      Uterine B cell dynamics during pregnancy - Immune regulation of...
      DATE: January 27, 2021 TIME: 9am PST Well-timed interaction of correctly functioning maternal immune cells is essential to facilitate healthy placenta formation, as the uterine immune enviro...
      Speaker: Marilen Benner
      Sponsored By: Beckman Coulter Life Sciences
      11
      SEP 08, 2020 | 11:00 PM
      Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
      Deep mutational scanning of SARS-CoV-2 receptor binding domain...
      The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutraliz...
      Speaker: Tyler Starr, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      4
      SEP 08, 2020 | 12:00 PM
      Keynote Presentation: Structure-based Vaccine Design for COVID-19 and other Respiratory Viruses
      Keynote Presentation: Structure-based Vaccine Design for COVID-19...
      While the frequency of pandemic threats seems to be increasing, we fortunately have new tools and technologies to make vaccines with more precision and speed and that support a more proactiv...
      Speaker: Barney S. Graham, MD, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      JUL 29, 2020 | 10:00 AM
      Metabolic control of T cell tolerance and antitumor immunity
      Metabolic control of T cell tolerance and antitumor immunity
      Coordination of immune cell metabolic programs with cell fate and state is a fundamental determinant of immune responses. Emerging evidence highlights that the interplay between immune signa...
      Speaker: Hongbo Chi, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 29, 2020 | 7:00 AM
      What intratumoral Tregs eat makes them strong, but vulnerable: a new metabolic intervention for cancer immunotherapy
      What intratumoral Tregs eat makes them strong, but vulnerable:...
      Metabolic reprogramming is critical for governing proper T cell immune responses, including activation, production of effector molecule, migration and differentiation. The metabolic stress T...
      Speaker: Ping-Chih Ho, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      2
      JUN 18, 2020 | 9:00 AM
      Unveiling the role of T cell dysfunction in the development and progression of glioblastoma
      Unveiling the role of T cell dysfunction in the development and...
      DATE: June 18, 2020 TIME: 9:00am PDT, 12:00pm EDT Despite the success of immunotherapy against several malignancies including melanoma and lung adenocarcinoma, glioblastoma remains the excep...
      Speaker: Felipe Galvez Cancino, Ph.D.
      Sponsored By: Thermo Fisher Scientific/Gibco
      18 2
      JUN 17, 2020 | 3:00 PM
      COVID-19: Enrichment and analysis of rare antigen- and virus-specific T cells
      COVID-19: Enrichment and analysis of rare antigen- and virus-specific...
      Analysis of antigen- and virus-specific T cells is essential to the understanding of fundamental immunological processes in the contexts of e.g. infectious diseases, immuno-oncology, as well...
      Speaker: Dr. Marcello Stein
      Presented at: Coronavirus Series
      Sponsored By: Miltenyi Biotec
      1
      MAY 27, 2020 | 9:00 AM
      Enrichment & analysis of rare antigen & virus-specific T cells
      Enrichment & analysis of rare antigen & virus-specific T cells
      DATE: May 27, 2020 TIME: 9:00am PT Analysis of antigen- and virus-specific T cells is essential to the understanding of fundamental immunological processes in the contexts of e.g. infectious...
      Speaker: Marcello Stein, PhD.
      Sponsored By: Miltenyi Biotec
      20
      MAY 20, 2020 | 1:15 PM
      Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein-Induced Clustering of CD3+ T Cells & CD123+ AML Cells in Bone Marrow Biopsies Is Associated with Response to Treatment...
      Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart®...
      Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
      Speaker: Jan Davidson, MD, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 19, 2020 | 10:00 AM
      Applications in Biomarker Discovery and CAR T Therapy Using High-plex RNA & Protein Spatial Profiling on FFPE Tissue
      Applications in Biomarker Discovery and CAR T Therapy Using High-plex...
      The GeoMx Digital Spatial Profiling technology enables high-plex RNA and protein profiling of any region within any tissue type. This workshop will highlight the latest developments toward e...
      Speaker: PLENARY: Carl June, MD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      APR 29, 2020 | 6:00 AM
      Traveling into the unknown: challenges and opportunities for 21st Century Translational Medicine
      Traveling into the unknown: challenges and opportunities for 21st...
      Translational medicine has been fairly unsuccessful in translating innovation from the lab towards the clinics and back again. Many reasons account for the failure leading to a massive waste...
      Speaker: Berent Prakken. PhD
      Presented at: xMAP® Connect Virtual Conference (On-Demand)
      2
    SEP 08, 2022 | 12:00 PM
    Panel Presentation: RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral Pathogens, Including SARS-CoV-2
    Panel Presentation: RT-LAMP: Best Practices and Tips to Accelerate...
    Loop-mediated isothermal amplification (LAMP) uses a stand-displacing DNA polymerase and four to six primers to rapidly amplify DNA at a single temperature. By eliminating temperature cyclin...
    Speaker: Ingrida Vendelė, PhD , Leann Buhrow, PhD
    Presented at: Microbiology Week Virtual Event Series 2022
    Sponsored By: Thermo Fisher Scientific
    4
    JUL 12, 2022 | 8:00 AM
    Solutions for dendritic cell research
    Solutions for dendritic cell research
    Date: July 12, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CEST) Dendritic cells (DCs) are a heterogeneous population of myeloid immune cells that act as peripheral sentinels specializin...
    Speaker: Dr. Nizar Yousif
    Sponsored By: Miltenyi Biotec
    15
    APR 19, 2022 | 12:00 PM
    C.E. CREDITS
    RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral Pathogens, Including SARS-CoV-2
    RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral...
    Loop-mediated isothermal amplification (LAMP) uses a stand-displacing DNA polymerase and four to six primers to rapidly amplify DNA at a single temperature. By eliminating temperature cyclin...
    Speaker: Ingrida Vendelė, PhD , Leann Buhrow, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: Thermo Fisher Scientific
    3
    FEB 23, 2022 | 6:00 AM
    Autoantibodies as Biomarkers in Immuno-oncology
    Autoantibodies as Biomarkers in Immuno-oncology
    Cancer still accounts for nearly 1 in every 4 deaths worldwide. New immunotherapies have the power to induce durable responses in patients with fatal cancers, but only a small percentage of...
    Speaker: Hans-Dieter Zucht, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2022
    Sponsored By: Luminex - A DiaSorin Company
    10
    DEC 09, 2021 | 8:00 AM
    Reprogramming human regulatory T cell specificity with a novel anti-HLA-A2 chimeric antigen receptor
    Reprogramming human regulatory T cell specificity with a novel...
    Date: December 9, 2021 Time: 8:00am (PDT), 11:00am (EDT) Engineering human regulatory T cells (Tregs) with a chimeric antigen receptor (CAR) targeting donorderived human leukocyte antigen (H...
    Speaker: Leonardo Ferreira
    Sponsored By: Thermo Fisher Scientific/Gibco
    5
     
     
  • NOV 30, 2021 | 7:00 AM
    A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
    A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
    Date: November 30, 2021 Time: 7:00am (PDT), 10:00am (EDT) Wastewater Surveillance programs for SARS-CoV-2 are being implemented by health authorities globally. Many laboratories are currentl...
    Speaker: Subhanjan Mondal , Carlotta Olivero
    Sponsored By: Promega
    8 1
    OCT 28, 2021 | 9:00 AM
    RT-LAMP: Best practices and tips to accelerate detection of viral pathogens, including SARS-CoV-2
    RT-LAMP: Best practices and tips to accelerate detection of viral...
    Date: October 28, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Loop-mediated isothermal amplification (LAMP) uses a stand-displacing DNA polymerase and four to six primers to rapidly amplify DNA a...
    Speaker: Ingrida Vendelė, PhD , Leann Buhrow, PhD
    Sponsored By: Thermo Fisher Scientific
    11
    JUN 09, 2021 | 8:00 AM
    Working with antigen-specific T cells
    Working with antigen-specific T cells
    DATE: June 9, 2021 TIME: 8:00am PDT Analyzing antigen-specific T cells is essential to understand fundamental immunological processes in the contexts of immuno-oncology, infectious dise...
    Speaker: Lorenz Fülle, PhD
    Sponsored By: Miltenyi Biotec
    10 3
    JUN 02, 2021 | 10:30 AM
    Keynote Presentation: New Checkpoints and Biomarkers
    Keynote Presentation: New Checkpoints and Biomarkers
    Learning Objectives: 1. Understand how the outcome of PD-1 blockade is a summation of increased Teffector activity and increased Treg suppressive activity 2. Explain how PD-1 blockade leads...
    Speaker: Gordon Freeman, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    2
    JUN 02, 2021 | 12:00 AM
    IDO in Melanoma..... Deserves Further Evaluation
    IDO in Melanoma..... Deserves Further Evaluation
    Learning Objectives: 1. Learn about IDO pathway 2. IDO rule in cancer...
    Speaker: Yousef Zakharia, MD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    1
     
     
  • APR 21, 2021 | 12:00 AM
    Past, Present and Future of Engineered Cell Therapy
    Past, Present and Future of Engineered Cell Therapy
    Engineered cell therapy is an emerging field of science to target and treat cancer. Current strategies include utilizing immune cells such as T cells, NK cells and Macrophages or other cells...
    Speaker: Janani Krishnamurthy, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    2
    MAR 16, 2021 | 8:00 AM
    The latest developments for enriching and analyzing antigen- and virus-specific T cells
    The latest developments for enriching and analyzing antigen- and...
    DATE: March 09, 2021 TIME: 08:00am PST The COVID-19 pandemic has placed urgency on precise analysis of rare antigen- and virus-specific T cells. At Miltenyi Biotec, we offer a complete workf...
    Speaker: Lorenz Fülle, PhD
    Sponsored By: Miltenyi Biotec
    12
    FEB 10, 2021 | 12:00 AM
    Experimental design strategies in primate trials that embrace the clinical schema to enhance translation
    Experimental design strategies in primate trials that embrace...
    Primates have been essential in unlocking novel immune mechanisms that have driven development of groundbreaking new drugs in infectious disease and transplantation, amongst others related t...
    Speaker: Melanie L. Graham, MPH, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2021
    5
    JAN 27, 2021 | 9:00 AM
    Uterine B cell dynamics during pregnancy - Immune regulation of the placenta
    Uterine B cell dynamics during pregnancy - Immune regulation of...
    DATE: January 27, 2021 TIME: 9am PST Well-timed interaction of correctly functioning maternal immune cells is essential to facilitate healthy placenta formation, as the uterine immune enviro...
    Speaker: Marilen Benner
    Sponsored By: Beckman Coulter Life Sciences
    11
    SEP 08, 2020 | 11:00 PM
    Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
    Deep mutational scanning of SARS-CoV-2 receptor binding domain...
    The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutraliz...
    Speaker: Tyler Starr, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    4
     
     
  • SEP 08, 2020 | 12:00 PM
    Keynote Presentation: Structure-based Vaccine Design for COVID-19 and other Respiratory Viruses
    Keynote Presentation: Structure-based Vaccine Design for COVID-19...
    While the frequency of pandemic threats seems to be increasing, we fortunately have new tools and technologies to make vaccines with more precision and speed and that support a more proactiv...
    Speaker: Barney S. Graham, MD, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    JUL 29, 2020 | 10:00 AM
    Metabolic control of T cell tolerance and antitumor immunity
    Metabolic control of T cell tolerance and antitumor immunity
    Coordination of immune cell metabolic programs with cell fate and state is a fundamental determinant of immune responses. Emerging evidence highlights that the interplay between immune signa...
    Speaker: Hongbo Chi, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    JUL 29, 2020 | 7:00 AM
    What intratumoral Tregs eat makes them strong, but vulnerable: a new metabolic intervention for cancer immunotherapy
    What intratumoral Tregs eat makes them strong, but vulnerable:...
    Metabolic reprogramming is critical for governing proper T cell immune responses, including activation, production of effector molecule, migration and differentiation. The metabolic stress T...
    Speaker: Ping-Chih Ho, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    2
    JUN 18, 2020 | 9:00 AM
    Unveiling the role of T cell dysfunction in the development and progression of glioblastoma
    Unveiling the role of T cell dysfunction in the development and...
    DATE: June 18, 2020 TIME: 9:00am PDT, 12:00pm EDT Despite the success of immunotherapy against several malignancies including melanoma and lung adenocarcinoma, glioblastoma remains the excep...
    Speaker: Felipe Galvez Cancino, Ph.D.
    Sponsored By: Thermo Fisher Scientific/Gibco
    18 2
    JUN 17, 2020 | 3:00 PM
    COVID-19: Enrichment and analysis of rare antigen- and virus-specific T cells
    COVID-19: Enrichment and analysis of rare antigen- and virus-specific...
    Analysis of antigen- and virus-specific T cells is essential to the understanding of fundamental immunological processes in the contexts of e.g. infectious diseases, immuno-oncology, as well...
    Speaker: Dr. Marcello Stein
    Presented at: Coronavirus Series
    Sponsored By: Miltenyi Biotec
    1
     
     
  • MAY 27, 2020 | 9:00 AM
    Enrichment & analysis of rare antigen & virus-specific T cells
    Enrichment & analysis of rare antigen & virus-specific T cells
    DATE: May 27, 2020 TIME: 9:00am PT Analysis of antigen- and virus-specific T cells is essential to the understanding of fundamental immunological processes in the contexts of e.g. infectious...
    Speaker: Marcello Stein, PhD.
    Sponsored By: Miltenyi Biotec
    20
    MAY 20, 2020 | 1:15 PM
    Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein-Induced Clustering of CD3+ T Cells & CD123+ AML Cells in Bone Marrow Biopsies Is Associated with Response to Treatment...
    Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart®...
    Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
    Speaker: Jan Davidson, MD, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    MAY 19, 2020 | 10:00 AM
    Applications in Biomarker Discovery and CAR T Therapy Using High-plex RNA & Protein Spatial Profiling on FFPE Tissue
    Applications in Biomarker Discovery and CAR T Therapy Using High-plex...
    The GeoMx Digital Spatial Profiling technology enables high-plex RNA and protein profiling of any region within any tissue type. This workshop will highlight the latest developments toward e...
    Speaker: PLENARY: Carl June, MD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    APR 29, 2020 | 6:00 AM
    Traveling into the unknown: challenges and opportunities for 21st Century Translational Medicine
    Traveling into the unknown: challenges and opportunities for 21st...
    Translational medicine has been fairly unsuccessful in translating innovation from the lab towards the clinics and back again. Many reasons account for the failure leading to a massive waste...
    Speaker: Berent Prakken. PhD
    Presented at: xMAP® Connect Virtual Conference (On-Demand)
    2
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