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    Kinases

    A kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy molecule to specific substrates.

    Webinars

    • MAY 12, 2016 | 12:00 PM
      Learning Biology from Networks and their Structure
      Learning Biology from Networks and their Structure
      Network models are an invaluable tool for integrating multiple data types and for modeling interactions between biological elements. One common question that arises, however, is what to do wi...
      Speaker: John Platig, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2016
      2
      MAY 04, 2016 | 7:00 AM
      Structure and function of the Parkinson's disease-associated protein LRRK2
      Structure and function of the Parkinson's disease-associated protein...
      LRRK2 is a large (2,527 amino acids) multi-domain protein consisting of 7 putative domains, including a Ras-like GTPase domain called ‘Ras of complex proteins’ (Roc) followed by a...
      Speaker: Quyen Hoang, PhD
      Presented at: 2016 Gibco ExpressionWorld
      2
      APR 06, 2016 | 6:00 AM
      EFIRM Liquid Biopsy
      EFIRM Liquid Biopsy
      The advent of personalized medicine employing molecular targeted therapies has markedly changed the treatment of cancer in the past 10 years. Although tumor tissue biopsy-based genotyping is...
      Speaker: David Wong DMD, DMSc
      Presented at: Molecular Diagnostics Virtual Event Series 2016
      5 1
      FEB 02, 2016 | 9:00 AM
      Arrays or RNA-Seq? Choosing the right tool for the job
      Arrays or RNA-Seq? Choosing the right tool for the job
      DATE: February 2nd, 2016 TIME:  9am pacific time, 12pm eastern time What is the most appropriate technology to empower your research?   Next generation sequencing (NGS) for RN...
      Speaker: Sridar Chittur, PhD, MBA , Yesim Gökmen-Polar, PhD
      Sponsored By: Affymetrix, Affymetrix
      11 3
      JAN 21, 2016 | 8:00 AM
      How to identify key genes with CRISPR-Cas9 and shRNA screens
      How to identify key genes with CRISPR-Cas9 and shRNA screens
      DATE:  January 21, 2016 TIME:   8am Pacific time, 11am Eastern time In this webinar, you will learn:  basics of pooled lentiviral screening workflows implications of ...
      Speaker: Anja Smith, PhD
      Sponsored By: Dharmacon, Dharmacon
      18 1
      NOV 04, 2015 | 11:00 AM
      Advances in AMPK and Autophagy signaling
      Advances in AMPK and Autophagy signaling
      DATE: November 4th, 2015 TIME: 11:00am Pacific time, 2:00pm Eastern time AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains met...
      Speaker: Reuben Shaw, PhD
      Sponsored By: Cell Signaling Technology, Cell Signaling Technology
      14 1
      JUN 17, 2015 | 8:00 AM
      Real-Time Profiling of Tumor Heterogeneity in Metastatic Disease
      Real-Time Profiling of Tumor Heterogeneity in Metastatic Disease
      DATE: June 17th, 2015TIME: 8am Pacific time, 11am Eastern timeSpatial heterogeneity of tumors has been identified within and between metastatic lesions and can be visualized wit...
      Speaker: Mark Landers
      Sponsored By: Epic Sciences, Epic Sciences
      15 2
      MAY 13, 2015 | 3:00 PM
      Using the network architecture of eQTLs to understand complex traits
      Using the network architecture of eQTLs to understand complex...
      Genome Wide Association Studies (GWAS) and eQTL analyses are producing huge numbers of associations and show no signs of slowing. There are now more than 8,500 SNPs associated with more than...
      Speaker: John Platig, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2015
      2
      MAR 18, 2015 | 10:30 AM
      Special Lecturer - Oxidative Stress in Schizophrenia: a Translational Approach
      Special Lecturer - Oxidative Stress in Schizophrenia: a Translational...
      Schizophrenia is a severe psychiatric disorder affecting 1% of the world’s population, leading to high human, social and economic burdens. Understanding how the interaction of gene and...
      Speaker: Kim Quang Do, PhD
      Presented at: Neuroscience Virtual Event Series 2015
      12
      OCT 30, 2014 | 10:30 AM
      Therapeutic Drug Monitoring (TDM) in Cancer Chemotherapy: A Tool for Optimizing Drug Management
      Therapeutic Drug Monitoring (TDM) in Cancer Chemotherapy: A Tool...
      Many drugs currently used for anti-cancer therapy demonstrate significant inter-individual variability that cannot be normalized using body weight or body surface area. There is an increasing...
      Speaker: William Clarke, PhD, MBA, DABCC
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      10
      OCT 30, 2014 | 6:00 AM
      Epigenetic Dysregulation in the Pathogenesis of Myeloproliferative Neoplasms
      Epigenetic Dysregulation in the Pathogenesis of Myeloproliferative...
      When the BCR/ABL1 fusion protein was identified in chronic myelogenous leukemia and the JAK2 V617F mutation was identified in patients with other myeloproliferative neoplasms (MPNs) such as p...
      Speaker: Kristin Landis-Piwowar, PhD, MLS
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      8
      OCT 29, 2014 | 3:00 PM
      Drug-tailored, efficacy-predictive and prognostic biomarker approaches for proper patient selection
      Drug-tailored, efficacy-predictive and prognostic biomarker approaches...
      Over the last decade we have witnessed tremendous advances in our understanding of the underlying molecular alterations in human cancer. This has stimulated excitement for our ability to deve...
      Speaker: Peter Blume-Jensen, MD, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      0
      OCT 29, 2014 | 9:00 AM
      miRNA Biomarker Discovery: Technologies, workflows, and data analysis solutions for discovering your unique signature
      miRNA Biomarker Discovery: Technologies, workflows, and data analysis...
      Circulating miRNAs have great potential as biomarkers due to their aberrant expression in cancer and other diseases. However, miRNAs from body fluids are hard to obtain in amounts sufficient...
      Speaker: Jonathan Shaffer, PhD, MBA
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      18
      SEP 16, 2014 | 10:00 AM
      Expanded clinical research opportunities for Crizotinib identified from an analysis of over 5,000 exomes
      Expanded clinical research opportunities for Crizotinib identified...
      Patients with chromosomal rearrangements resulting in fusion proteins are among the most responsive to published targeted therapy. For example, targeting of the EML4-ALK fusion in non-small c...
      Speaker: Sean Eddy, PhD
      Presented at: Advanced Genomics in Clinical and Translational Research - Informing end-to-end cancer drug development with bioinformatics
      12
      AUG 20, 2014 | 10:45 AM
      OncoScan Assay for copy number from FFPE. Publications & cases on actionable CNV detection
      OncoScan Assay for copy number from FFPE. Publications & cases...
      A recent publication in Nature Genetics1 analyzed TCGA data, and classified solid tumors into two mutually exclusive classes: C class tumors, driven by copy number alterations; and M class tu...
      Speaker: Padma Sundar, MBA, MPH
      Presented at: Genetics and Genomics Virtual Event Series 2014
      14
      MAY 29, 2014 | 12:00 PM
      Navigating the Complexities of the Human Oncoproteome with the SigNET KnowledgeBank
      Navigating the Complexities of the Human Oncoproteome with the...
      The human genome encodes ~21,500 proteins that are subject to reversible phosphorylation at nearly 1 million phosphosites by about 538 protein kinases and 156 protein phosphatases. Amongst ot...
      Speaker: Steve Pelech, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2014
      46
      MAR 19, 2014 | 12:00 PM
      Src Regulation of Lamellipodia, Filopodia, and Substrate-Cytoskeletal Coupling in Neuronal Growth Cones
      Src Regulation of Lamellipodia, Filopodia, and Substrate-Cytoskeletal...
      Axonal growth and pathfinding is fundamental to the development and regeneration of the nervous system. Src tyrosine kinase has been implicated in this process; however, the detailed molecula...
      Speaker: Daniel Suter, PhD
      Presented at: Neuroscience Virtual Event Series 2014
      0
      MAR 19, 2014 | 12:00 PM
      Abeta oligomer receptor antagonists as disease-modifying Alzheimers therapeutics
      Abeta oligomer receptor antagonists as disease-modifying Alzheimers...
      Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic Amyloid beta (Abeta)1-42 oligomers is proposed to underlie cognitive decline in Alzheimers disease (AD). Syn...
      Speaker: Susan Catalano, PhD
      Presented at: Neuroscience Virtual Event Series 2014
      46
      MAR 19, 2014 | 10:00 AM
      NMDA receptor regulation in health and disease
      NMDA receptor regulation in health and disease
      Neuron-glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system. Microglia have been found to play a causal role...
      Speaker: Michael Salter, MD, PhD, FRSC
      Presented at: Neuroscience Virtual Event Series 2014
      54
      OCT 17, 2013 | 2:00 PM
      C.E. CREDITS
      Oncoproteins K-Ras and Pim kinases as molecular targets in pancreatic cancer
      Oncoproteins K-Ras and Pim kinases as molecular targets in pancreatic...
      Pancreatic cancer is the 4th most common cause of cancer deaths in the United States. Due to the aggressive nature of this cancer and the lack of biomarkers for early detection, the incidence...
      Speaker: Antonio T. Baines, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      72
      OCT 16, 2013 | 3:00 PM
      C.E. CREDITS
      The roles of Ack family kinases in Drosophila development
      The roles of Ack family kinases in Drosophila development
      Deregulation of ACK1, a non-receptor tyrosine kinase originally identified by its ability to bind to GTP-bound Cdc42 (hence the name: activated Cdc42-associated kinase)(Manser et al., 1993),...
      Speaker: Henry Chang, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      42
      OCT 16, 2013 | 2:00 PM
      C.E. CREDITS
      Novel therapies for ALK mutated cancers
      Novel therapies for ALK mutated cancers
      Non Small Cell Lung Cancer (NSCLC) is one of the most significant causes of cancer-related mortality worldwide. In about 6-7% of NSCLC, rearrangements involving the Anaplastic Lymphoma Kinase...
      Speaker: Roberto Chiarle, MD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      32
      OCT 16, 2013 | 7:00 AM
      C.E. CREDITS
      Prognostic, predictive, and surrogate biomarkers in men with castration resistant metastatic prostate cancer
      Prognostic, predictive, and surrogate biomarkers in men with castration...
      With the rapid rise in the number of therapeutic options for men with castration-resistant prostate cancer (CRPC) comes increasingly complicated treatment decision-making, emphasizing the nee...
      Speaker: Andrew Armstrong, MD ScM FACP
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      96
      AUG 21, 2013 | 3:00 PM
      C.E. CREDITS
      Evolution of Alu elements in long non-coding RNA and mRNA
      Evolution of Alu elements in long non-coding RNA and mRNA
      Long non-coding RNAs (lncRNA) are a novel class of RNA molecule that are emerging as important regulators of gene transcription and post-transcriptional events. lncRNAs have been shown to reg...
      Speaker: Daniel Caffrey, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      42
    MAY 12, 2016 | 12:00 PM
    Learning Biology from Networks and their Structure
    Learning Biology from Networks and their Structure
    Network models are an invaluable tool for integrating multiple data types and for modeling interactions between biological elements. One common question that arises, however, is what to do wi...
    Speaker: John Platig, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2016
    2
    MAY 04, 2016 | 7:00 AM
    Structure and function of the Parkinson's disease-associated protein LRRK2
    Structure and function of the Parkinson's disease-associated protein...
    LRRK2 is a large (2,527 amino acids) multi-domain protein consisting of 7 putative domains, including a Ras-like GTPase domain called ‘Ras of complex proteins’ (Roc) followed by a...
    Speaker: Quyen Hoang, PhD
    Presented at: 2016 Gibco ExpressionWorld
    2
    APR 06, 2016 | 6:00 AM
    EFIRM Liquid Biopsy
    EFIRM Liquid Biopsy
    The advent of personalized medicine employing molecular targeted therapies has markedly changed the treatment of cancer in the past 10 years. Although tumor tissue biopsy-based genotyping is...
    Speaker: David Wong DMD, DMSc
    Presented at: Molecular Diagnostics Virtual Event Series 2016
    5 1
    FEB 02, 2016 | 9:00 AM
    Arrays or RNA-Seq? Choosing the right tool for the job
    Arrays or RNA-Seq? Choosing the right tool for the job
    DATE: February 2nd, 2016 TIME:  9am pacific time, 12pm eastern time What is the most appropriate technology to empower your research?   Next generation sequencing (NGS) for RN...
    Speaker: Sridar Chittur, PhD, MBA , Yesim Gökmen-Polar, PhD
    Sponsored By: Affymetrix, Affymetrix
    11 3
    JAN 21, 2016 | 8:00 AM
    How to identify key genes with CRISPR-Cas9 and shRNA screens
    How to identify key genes with CRISPR-Cas9 and shRNA screens
    DATE:  January 21, 2016 TIME:   8am Pacific time, 11am Eastern time In this webinar, you will learn:  basics of pooled lentiviral screening workflows implications of ...
    Speaker: Anja Smith, PhD
    Sponsored By: Dharmacon, Dharmacon
    18 1
     
     
  • NOV 04, 2015 | 11:00 AM
    Advances in AMPK and Autophagy signaling
    Advances in AMPK and Autophagy signaling
    DATE: November 4th, 2015 TIME: 11:00am Pacific time, 2:00pm Eastern time AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains met...
    Speaker: Reuben Shaw, PhD
    Sponsored By: Cell Signaling Technology, Cell Signaling Technology
    14 1
    JUN 17, 2015 | 8:00 AM
    Real-Time Profiling of Tumor Heterogeneity in Metastatic Disease
    Real-Time Profiling of Tumor Heterogeneity in Metastatic Disease
    DATE: June 17th, 2015TIME: 8am Pacific time, 11am Eastern timeSpatial heterogeneity of tumors has been identified within and between metastatic lesions and can be visualized wit...
    Speaker: Mark Landers
    Sponsored By: Epic Sciences, Epic Sciences
    15 2
    MAY 13, 2015 | 3:00 PM
    Using the network architecture of eQTLs to understand complex traits
    Using the network architecture of eQTLs to understand complex...
    Genome Wide Association Studies (GWAS) and eQTL analyses are producing huge numbers of associations and show no signs of slowing. There are now more than 8,500 SNPs associated with more than...
    Speaker: John Platig, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2015
    2
    MAR 18, 2015 | 10:30 AM
    Special Lecturer - Oxidative Stress in Schizophrenia: a Translational Approach
    Special Lecturer - Oxidative Stress in Schizophrenia: a Translational...
    Schizophrenia is a severe psychiatric disorder affecting 1% of the world’s population, leading to high human, social and economic burdens. Understanding how the interaction of gene and...
    Speaker: Kim Quang Do, PhD
    Presented at: Neuroscience Virtual Event Series 2015
    12
    OCT 30, 2014 | 10:30 AM
    Therapeutic Drug Monitoring (TDM) in Cancer Chemotherapy: A Tool for Optimizing Drug Management
    Therapeutic Drug Monitoring (TDM) in Cancer Chemotherapy: A Tool...
    Many drugs currently used for anti-cancer therapy demonstrate significant inter-individual variability that cannot be normalized using body weight or body surface area. There is an increasing...
    Speaker: William Clarke, PhD, MBA, DABCC
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    10
     
     
  • OCT 30, 2014 | 6:00 AM
    Epigenetic Dysregulation in the Pathogenesis of Myeloproliferative Neoplasms
    Epigenetic Dysregulation in the Pathogenesis of Myeloproliferative...
    When the BCR/ABL1 fusion protein was identified in chronic myelogenous leukemia and the JAK2 V617F mutation was identified in patients with other myeloproliferative neoplasms (MPNs) such as p...
    Speaker: Kristin Landis-Piwowar, PhD, MLS
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    8
    OCT 29, 2014 | 3:00 PM
    Drug-tailored, efficacy-predictive and prognostic biomarker approaches for proper patient selection
    Drug-tailored, efficacy-predictive and prognostic biomarker approaches...
    Over the last decade we have witnessed tremendous advances in our understanding of the underlying molecular alterations in human cancer. This has stimulated excitement for our ability to deve...
    Speaker: Peter Blume-Jensen, MD, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    0
    OCT 29, 2014 | 9:00 AM
    miRNA Biomarker Discovery: Technologies, workflows, and data analysis solutions for discovering your unique signature
    miRNA Biomarker Discovery: Technologies, workflows, and data analysis...
    Circulating miRNAs have great potential as biomarkers due to their aberrant expression in cancer and other diseases. However, miRNAs from body fluids are hard to obtain in amounts sufficient...
    Speaker: Jonathan Shaffer, PhD, MBA
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    18
    SEP 16, 2014 | 10:00 AM
    Expanded clinical research opportunities for Crizotinib identified from an analysis of over 5,000 exomes
    Expanded clinical research opportunities for Crizotinib identified...
    Patients with chromosomal rearrangements resulting in fusion proteins are among the most responsive to published targeted therapy. For example, targeting of the EML4-ALK fusion in non-small c...
    Speaker: Sean Eddy, PhD
    Presented at: Advanced Genomics in Clinical and Translational Research - Informing end-to-end cancer drug development with bioinformatics
    12
    AUG 20, 2014 | 10:45 AM
    OncoScan Assay for copy number from FFPE. Publications & cases on actionable CNV detection
    OncoScan Assay for copy number from FFPE. Publications & cases...
    A recent publication in Nature Genetics1 analyzed TCGA data, and classified solid tumors into two mutually exclusive classes: C class tumors, driven by copy number alterations; and M class tu...
    Speaker: Padma Sundar, MBA, MPH
    Presented at: Genetics and Genomics Virtual Event Series 2014
    14
     
     
  • MAY 29, 2014 | 12:00 PM
    Navigating the Complexities of the Human Oncoproteome with the SigNET KnowledgeBank
    Navigating the Complexities of the Human Oncoproteome with the...
    The human genome encodes ~21,500 proteins that are subject to reversible phosphorylation at nearly 1 million phosphosites by about 538 protein kinases and 156 protein phosphatases. Amongst ot...
    Speaker: Steve Pelech, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2014
    46
    MAR 19, 2014 | 12:00 PM
    Src Regulation of Lamellipodia, Filopodia, and Substrate-Cytoskeletal Coupling in Neuronal Growth Cones
    Src Regulation of Lamellipodia, Filopodia, and Substrate-Cytoskeletal...
    Axonal growth and pathfinding is fundamental to the development and regeneration of the nervous system. Src tyrosine kinase has been implicated in this process; however, the detailed molecula...
    Speaker: Daniel Suter, PhD
    Presented at: Neuroscience Virtual Event Series 2014
    0
    MAR 19, 2014 | 12:00 PM
    Abeta oligomer receptor antagonists as disease-modifying Alzheimers therapeutics
    Abeta oligomer receptor antagonists as disease-modifying Alzheimers...
    Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic Amyloid beta (Abeta)1-42 oligomers is proposed to underlie cognitive decline in Alzheimers disease (AD). Syn...
    Speaker: Susan Catalano, PhD
    Presented at: Neuroscience Virtual Event Series 2014
    46
    MAR 19, 2014 | 10:00 AM
    NMDA receptor regulation in health and disease
    NMDA receptor regulation in health and disease
    Neuron-glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system. Microglia have been found to play a causal role...
    Speaker: Michael Salter, MD, PhD, FRSC
    Presented at: Neuroscience Virtual Event Series 2014
    54
    OCT 17, 2013 | 2:00 PM
    C.E. CREDITS
    Oncoproteins K-Ras and Pim kinases as molecular targets in pancreatic cancer
    Oncoproteins K-Ras and Pim kinases as molecular targets in pancreatic...
    Pancreatic cancer is the 4th most common cause of cancer deaths in the United States. Due to the aggressive nature of this cancer and the lack of biomarkers for early detection, the incidence...
    Speaker: Antonio T. Baines, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    72
     
     
  • OCT 16, 2013 | 3:00 PM
    C.E. CREDITS
    The roles of Ack family kinases in Drosophila development
    The roles of Ack family kinases in Drosophila development
    Deregulation of ACK1, a non-receptor tyrosine kinase originally identified by its ability to bind to GTP-bound Cdc42 (hence the name: activated Cdc42-associated kinase)(Manser et al., 1993),...
    Speaker: Henry Chang, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    42
    OCT 16, 2013 | 2:00 PM
    C.E. CREDITS
    Novel therapies for ALK mutated cancers
    Novel therapies for ALK mutated cancers
    Non Small Cell Lung Cancer (NSCLC) is one of the most significant causes of cancer-related mortality worldwide. In about 6-7% of NSCLC, rearrangements involving the Anaplastic Lymphoma Kinase...
    Speaker: Roberto Chiarle, MD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    32
    OCT 16, 2013 | 7:00 AM
    C.E. CREDITS
    Prognostic, predictive, and surrogate biomarkers in men with castration resistant metastatic prostate cancer
    Prognostic, predictive, and surrogate biomarkers in men with castration...
    With the rapid rise in the number of therapeutic options for men with castration-resistant prostate cancer (CRPC) comes increasingly complicated treatment decision-making, emphasizing the nee...
    Speaker: Andrew Armstrong, MD ScM FACP
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    96
    AUG 21, 2013 | 3:00 PM
    C.E. CREDITS
    Evolution of Alu elements in long non-coding RNA and mRNA
    Evolution of Alu elements in long non-coding RNA and mRNA
    Long non-coding RNAs (lncRNA) are a novel class of RNA molecule that are emerging as important regulators of gene transcription and post-transcriptional events. lncRNAs have been shown to reg...
    Speaker: Daniel Caffrey, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    42
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