Tumor Microenvironment: is the cellular environment in which non-cancerous cells are present in the tumor. This environment including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules and the extracellular matrix .
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Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types, yet its mechanism remains unclear. By using a multi-omics approach, overlay of multiple spa...
BACKGROUND . Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms with variable clinical outcomes and an increased risk of progression to Acute Myeloid Leukemia (AM...
Glioblastoma (GBM) is an aggressive brain tumor characterized by marked intra- and inter-tumoral heterogeneity and inevitable recurrence. Although extracranial metastasis is rare, circulatin...
Advances in tissue-based technology in the past few years have created unprecedented opportunities to identify biomarkers of disease processes, especially within oncology by using multi-omic...
Immune checkpoint blockade (ICB) targeting T cells has enhanced clinical outcomes in patients with renal and bladder cancers; however, response rates remain limited, particularly in cases of...
Clinical effectiveness of immune therapies of solid tumors requires a) the induction or expansion of T cells able of recognizing multiple variants of cancer cells present in each cancer pati...
Breast cancer is a highly aggressive disease linked to poor clinical outcomes. Understanding the complex tumor microenvironment (TME) would help to identify novel therapeutic targets to impr...
High resolution surveys of the tumor microenvironment (TME) are needed to obtain a holistic portrait of the genetic, epigenetic, and cellular factors contributing to cancer progression. To t...
In this webinar, discover how Dr El Ahmar utilizes the BOND RX autostainer and image analysis workflow to stain formalin-fixed paraffin-embedded (FFPE) clinical trial samples with multiplex...
JUL 24, 2024 | 11:00 PM
C.E. CREDITS
Spatial transcriptomics offers a revolutionary approach to understanding the tumor microenvironment (TME) in solid tumors by preserving the spatial context of gene expression, which is cruci...
JUN 27, 2024 | 6:00 AM
C.E. CREDITS
High-resolution spatial transcriptomics stands at the forefront of technological advancements, offering transformative capabilities in the domain of tumor biology research. In this presentat...
Immunotherapies, including immune checkpoint inhibitors, have emerged as promising treatments for advanced cancers. However, a subset of patients exhibits resistance to such therapies, and t...
APR 30, 2024 | 10:30 AM
C.E. CREDITS
Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieve a durable complete response. Furthermore,...
Brain cancer research stands to benefit from the perspectives, tools, and methodologies of non-traditional fields, such as mechanical engineering. Here, I will discuss our engineering-based...
Understanding the spatial organization of the immune response within tumors is crucial for developing effective cancer immunotherapies. In this seminar, we delve into the interactions betwee...