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    Tumor Microenvironment

    Tumor Microenvironment: is the cellular environment in which non-cancerous cells are present in the tumor. This environment including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules and the extracellular matrix .

    Webinars

    • NOV 18, 2025 | 10:00 AM
      Spatial mapping of immunotherapy-refractory tumors provides insights into cancer-induced nerve injury as a novel mechanism of immunotherapy resistance
      Spatial mapping of immunotherapy-refractory tumors provides insights...
      Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types, yet its mechanism remains unclear. By using a multi-omics approach, overlay of multiple spa...
      Speaker: Erez Baruch
      Sponsored By: Lunaphore
      4
      NOV 05, 2025 | 9:00 AM
      Evaluation of immune dysregulation and its clinical implications in Myelodysplastic Syndromes
      Evaluation of immune dysregulation and its clinical implications...
      BACKGROUND . Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms with variable clinical outcomes and an increased risk of progression to Acute Myeloid Leukemia (AM...
      Speaker: Elena Riva, PhD
      Sponsored By: Beckman Coulter Life Sciences
      10
      OCT 21, 2025 | 7:00 AM
      Novel strategies for circulating tumor cell analysis in glioblastoma
      Novel strategies for circulating tumor cell analysis in glioblastoma
      Glioblastoma (GBM) is an aggressive brain tumor characterized by marked intra- and inter-tumoral heterogeneity and inevitable recurrence. Although extracranial metastasis is rare, circulatin...
      Speaker: Francesca Lessi, PhD , Cristina Ciccioli, PhD
      Sponsored By: ANGLE Plc
      15
      JUN 11, 2025 | 8:00 AM
      Decoding the Tumor Microenvironment with Paletrraâ„¢: Revolutionizing Biomarker Discovery in Clinical Trials
      Decoding the Tumor Microenvironment with Paletrraâ„¢: Revolutionizing...
      Advances in tissue-based technology in the past few years have created unprecedented opportunities to identify biomarkers of disease processes, especially within oncology by using multi-omic...
      Speaker: Kirsteen Maclean, PhD , Harry Nunns
      Sponsored By: NeoGenomics Laboratories, Inc.
      9
      MAY 13, 2025 | 9:00 AM
      A novel strategy targeting myeloid cells and T cells in Renal Cell Carcinoma
      A novel strategy targeting myeloid cells and T cells in Renal...
      Immune checkpoint blockade (ICB) targeting T cells has enhanced clinical outcomes in patients with renal and bladder cancers; however, response rates remain limited, particularly in cases of...
      Speaker: Marice Alcantara, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      11
      On Demand
      C.E. CREDITS
      Dendritic Cells in Cancer Immunotherapy: Vaccines, Live Adjuvants and DC-assisted T Cell Therapies
      Dendritic Cells in Cancer Immunotherapy: Vaccines, Live Adjuvants...
      Clinical effectiveness of immune therapies of solid tumors requires a) the induction or expansion of T cells able of recognizing multiple variants of cancer cells present in each cancer pati...
      Speaker: Pawel Kalinski, MD, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2025
      5
      NOV 19, 2024 | 8:00 AM
      Advancing Breast Cancer Research through Multiplex IHC: A Collaborative Approach by Leica Biosystems, Cell Signaling Technology, and HistoWiz
      Advancing Breast Cancer Research through Multiplex IHC: A Collaborative...
      Breast cancer is a highly aggressive disease linked to poor clinical outcomes. Understanding the complex tumor microenvironment (TME) would help to identify novel therapeutic targets to impr...
      Speaker: Troy Bloom , Tanni Rahman, PhD , Tracy Guido , Derek Papalegis
      Sponsored By: Leica Biosystems, Cell Signaling Technology , HistoWiz
      15
      NOV 07, 2024 | 8:00 AM
      Emerging methods to study an evolving landscape: Characterizing the tumor microenvironment with spatial biology
      Emerging methods to study an evolving landscape: Characterizing...
      High resolution surveys of the tumor microenvironment (TME) are needed to obtain a holistic portrait of the genetic, epigenetic, and cellular factors contributing to cancer progression. To t...
      Speaker: Andrea Radtke, PhD
      Sponsored By: Leica Microsystems
      9
      OCT 02, 2024 | 8:00 AM
      Unveiling Novel Biomarkers and their Spatial Distribution within the Tumor Microenvironment of Renal Cell Carcinoma Using the BOND RX and Image Analysis Workflow
      Unveiling Novel Biomarkers and their Spatial Distribution within...
      In this webinar, discover how Dr El Ahmar utilizes the BOND RX autostainer and image analysis workflow to stain formalin-fixed paraffin-embedded (FFPE) clinical trial samples with multiplex...
      Speaker: Nourhan El Ahmar, MD
      Sponsored By: Leica Biosystems
      11
      JUL 24, 2024 | 11:00 PM
      C.E. CREDITS
      How can clinicians use spatial transcriptomics data to interpret the complexity of tumor microenvironment?
      How can clinicians use spatial transcriptomics data to interpret...
      Spatial transcriptomics offers a revolutionary approach to understanding the tumor microenvironment (TME) in solid tumors by preserving the spatial context of gene expression, which is cruci...
      Speaker: Kwon Joong Na
      Sponsored By: Vizgen
      17
      JUN 27, 2024 | 6:00 AM
      C.E. CREDITS
      Exploring the immune-tumor microenvironment using high resolution single-cell spatial transcriptomics
      Exploring the immune-tumor microenvironment using high resolution...
      High-resolution spatial transcriptomics stands at the forefront of technological advancements, offering transformative capabilities in the domain of tumor biology research. In this presentat...
      Speaker: Roy Granit, PhD
      Sponsored By: Vizgen
      14
      MAY 15, 2024 | 9:00 AM
      Unveiling Tumor Immune Landscape: Using Multiplexed Whole-Tissue Imaging and AI-Powered Spatial Analysis
      Unveiling Tumor Immune Landscape: Using Multiplexed Whole-Tissue...
      Immunotherapies, including immune checkpoint inhibitors, have emerged as promising treatments for advanced cancers. However, a subset of patients exhibits resistance to such therapies, and t...
      Speaker: Vasundhara Agrawal
      Sponsored By: Leica Microsystems
      17
      APR 30, 2024 | 10:30 AM
      C.E. CREDITS
      Keynote Presentation: Engineering Metabolically Fit, Memory-Rich CAR T cells for Treatment of Cancer with Live Q&A
      Keynote Presentation: Engineering Metabolically Fit, Memory-Rich...
      Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieve a durable complete response. Furthermore,...
      Speaker: Sarwish Rafiq, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2024
      2
      On Demand
      C.E. CREDITS
      Immunomechanics and Mechano-Immunology in Brain Cancer
      Immunomechanics and Mechano-Immunology in Brain Cancer
      Brain cancer research stands to benefit from the perspectives, tools, and methodologies of non-traditional fields, such as mechanical engineering. Here, I will discuss our engineering-based...
      Speaker: Meenal Datta, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2024
      2
      On Demand
      C.E. CREDITS
      Investigating the Spatial Organization of the Immune Response in Tumors: Insights from the STAMP Model
      Investigating the Spatial Organization of the Immune Response...
      Understanding the spatial organization of the immune response within tumors is crucial for developing effective cancer immunotherapies. In this seminar, we delve into the interactions betwee...
      Speaker: Kate Carbone, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2024
      3
      On Demand
      C.E. CREDITS
      Engineering T Cells to Stimulate Endogenous Antitumor Immunity
      Engineering T Cells to Stimulate Endogenous Antitumor Immunity
      Adoptive cell therapy (ACT) is an immunotherapy that employs living immune cells to target and destroy cancer cells. However, the inhibitory tumor microenvironment features several obstacles...
      Speaker: Shannon K. Oda, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2024
      3
      APR 10, 2024 | 9:00 AM
      Linking spatial and temporal profiling to clinical settings through advanced machine learning
      Linking spatial and temporal profiling to clinical settings through...
      Leveraging advancements in spatially resolved single-cell profiling, our study enhances understanding of glioma evolution and the complex tumor microenvironment. Through spatially resolved m...
      Speaker: Carole Chedid, Ph.D , Univ.-Prof. Dr. med. Dieter Henrik Heiland
      Sponsored By: Vizgen
      13
      MAR 13, 2024 | 8:00 AM
      Spatial Protein and RNA Profiling: Seeing the Unseen in the Tumor Microenvironment
      Spatial Protein and RNA Profiling: Seeing the Unseen in the Tumor...
      Our presenter Jonathan Nowak, will discuss representative multiplexed assays for protein and RNA profiling built in the lab and discuss the necessary elements to operationalize this type of...
      Speaker: Jonathan Nowak MD, Ph.D.
      Sponsored By: Leica Biosystems
      14
      FEB 21, 2024 | 7:30 AM
      C.E. CREDITS
      Keynote Presentation: High-Throughput Interrogation of the Tumor Microenvironment Using Digital Image Analysis
      Keynote Presentation: High-Throughput Interrogation of the Tumor...
      Multiplex immunofluorescence is a powerful tool for phenotyping cells from a single tissue slide, while preserving spatial context. The MultiOmyxTM platform, offered as an end to end service...
      Speaker: Harry Nunns
      Presented at: Drug Discovery & Development Virtual Event Series 2024
      2
      On Demand
      C.E. CREDITS
      Validation of a hyperplex assay for single cell spatial analysis of multiple protein and RNA biomarkers within the tumor microenvironment (TME)
      Validation of a hyperplex assay for single cell spatial analysis...
      Spatial analysis of protein or gene expression is vital to understanding the distribution, phenotypes, and interactions between cells within tumor microenvironment (TME). Traditionally, mult...
      Speaker: Courtney Todorov, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2024
      2
      NOV 07, 2023 | 10:00 AM
      Understanding the Mechanisms of Resistance in CAR T Immunotherapy for Lymphoma and Strategies to Overcome Them
      Understanding the Mechanisms of Resistance in CAR T Immunotherapy...
      In the last 5 years, the US Food and Drug Administration has approved 4 anti-CD19 chimeric antigen receptor T cell (CART19) products for relapsed/refractory B cell lymphomas and leukemia. Ho...
      Speaker: Marco Ruella
      Sponsored By: Beckman Coulter Life Sciences
      22
      OCT 10, 2023 | 10:00 AM
      From Tissue to Insight: Genomic Testing Methodologies and Practical Considerations for Personalized Cancer Care
      From Tissue to Insight: Genomic Testing Methodologies and Practical...
      For patients with advanced non-small cell lung cancer (NSCLC), tissue samples are typically small biopsies. These samples undergo standard of care evaluation for >10 biomarkers to identif...
      Speaker: Kyle Strickland, MD, PhD , Rebecca Previs, MD
      Sponsored By: Labcorp Oncology
      29
      On Demand
      Multifaceted Community Analyses Uncover Novel Bacterial Species in the Colorectal Tumor Niche
      Multifaceted Community Analyses Uncover Novel Bacterial Species...
      The tumor-associated microbiota is an inherent component of the tumor microenvironment across various human cancer types1. Although members of tumor-associated microbiomes can be identified...
      Speaker: Martha Zepeda Rivera, PhD
      Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2023
      3
      On Demand
      Reprogramming Natural Killer Cells for Cancer Immunotherapy
      Reprogramming Natural Killer Cells for Cancer Immunotherapy
      Natural killer (NK) cells, immune cells with an innate ability to recognize and eliminate cancer cells, have emerged as attractive effectors in immunotherapy, owing in large part to their ab...
      Speaker: Sandro Matosevic, PhD
      Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2023
      4
    NOV 18, 2025 | 10:00 AM
    Spatial mapping of immunotherapy-refractory tumors provides insights into cancer-induced nerve injury as a novel mechanism of immunotherapy resistance
    Spatial mapping of immunotherapy-refractory tumors provides insights...
    Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types, yet its mechanism remains unclear. By using a multi-omics approach, overlay of multiple spa...
    Speaker: Erez Baruch
    Sponsored By: Lunaphore
    4
    NOV 05, 2025 | 9:00 AM
    Evaluation of immune dysregulation and its clinical implications in Myelodysplastic Syndromes
    Evaluation of immune dysregulation and its clinical implications...
    BACKGROUND . Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms with variable clinical outcomes and an increased risk of progression to Acute Myeloid Leukemia (AM...
    Speaker: Elena Riva, PhD
    Sponsored By: Beckman Coulter Life Sciences
    10
    OCT 21, 2025 | 7:00 AM
    Novel strategies for circulating tumor cell analysis in glioblastoma
    Novel strategies for circulating tumor cell analysis in glioblastoma
    Glioblastoma (GBM) is an aggressive brain tumor characterized by marked intra- and inter-tumoral heterogeneity and inevitable recurrence. Although extracranial metastasis is rare, circulatin...
    Speaker: Francesca Lessi, PhD , Cristina Ciccioli, PhD
    Sponsored By: ANGLE Plc
    15
    JUN 11, 2025 | 8:00 AM
    Decoding the Tumor Microenvironment with Paletrraâ„¢: Revolutionizing Biomarker Discovery in Clinical Trials
    Decoding the Tumor Microenvironment with Paletrraâ„¢: Revolutionizing...
    Advances in tissue-based technology in the past few years have created unprecedented opportunities to identify biomarkers of disease processes, especially within oncology by using multi-omic...
    Speaker: Kirsteen Maclean, PhD , Harry Nunns
    Sponsored By: NeoGenomics Laboratories, Inc.
    9
    MAY 13, 2025 | 9:00 AM
    A novel strategy targeting myeloid cells and T cells in Renal Cell Carcinoma
    A novel strategy targeting myeloid cells and T cells in Renal...
    Immune checkpoint blockade (ICB) targeting T cells has enhanced clinical outcomes in patients with renal and bladder cancers; however, response rates remain limited, particularly in cases of...
    Speaker: Marice Alcantara, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    11
     
     
  • On Demand
    C.E. CREDITS
    Dendritic Cells in Cancer Immunotherapy: Vaccines, Live Adjuvants and DC-assisted T Cell Therapies
    Dendritic Cells in Cancer Immunotherapy: Vaccines, Live Adjuvants...
    Clinical effectiveness of immune therapies of solid tumors requires a) the induction or expansion of T cells able of recognizing multiple variants of cancer cells present in each cancer pati...
    Speaker: Pawel Kalinski, MD, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2025
    5
    NOV 19, 2024 | 8:00 AM
    Advancing Breast Cancer Research through Multiplex IHC: A Collaborative Approach by Leica Biosystems, Cell Signaling Technology, and HistoWiz
    Advancing Breast Cancer Research through Multiplex IHC: A Collaborative...
    Breast cancer is a highly aggressive disease linked to poor clinical outcomes. Understanding the complex tumor microenvironment (TME) would help to identify novel therapeutic targets to impr...
    Speaker: Troy Bloom , Tanni Rahman, PhD , Tracy Guido , Derek Papalegis
    Sponsored By: Leica Biosystems, Cell Signaling Technology , HistoWiz
    15
    NOV 07, 2024 | 8:00 AM
    Emerging methods to study an evolving landscape: Characterizing the tumor microenvironment with spatial biology
    Emerging methods to study an evolving landscape: Characterizing...
    High resolution surveys of the tumor microenvironment (TME) are needed to obtain a holistic portrait of the genetic, epigenetic, and cellular factors contributing to cancer progression. To t...
    Speaker: Andrea Radtke, PhD
    Sponsored By: Leica Microsystems
    9
    OCT 02, 2024 | 8:00 AM
    Unveiling Novel Biomarkers and their Spatial Distribution within the Tumor Microenvironment of Renal Cell Carcinoma Using the BOND RX and Image Analysis Workflow
    Unveiling Novel Biomarkers and their Spatial Distribution within...
    In this webinar, discover how Dr El Ahmar utilizes the BOND RX autostainer and image analysis workflow to stain formalin-fixed paraffin-embedded (FFPE) clinical trial samples with multiplex...
    Speaker: Nourhan El Ahmar, MD
    Sponsored By: Leica Biosystems
    11
    JUL 24, 2024 | 11:00 PM
    C.E. CREDITS
    How can clinicians use spatial transcriptomics data to interpret the complexity of tumor microenvironment?
    How can clinicians use spatial transcriptomics data to interpret...
    Spatial transcriptomics offers a revolutionary approach to understanding the tumor microenvironment (TME) in solid tumors by preserving the spatial context of gene expression, which is cruci...
    Speaker: Kwon Joong Na
    Sponsored By: Vizgen
    17
     
     
  • JUN 27, 2024 | 6:00 AM
    C.E. CREDITS
    Exploring the immune-tumor microenvironment using high resolution single-cell spatial transcriptomics
    Exploring the immune-tumor microenvironment using high resolution...
    High-resolution spatial transcriptomics stands at the forefront of technological advancements, offering transformative capabilities in the domain of tumor biology research. In this presentat...
    Speaker: Roy Granit, PhD
    Sponsored By: Vizgen
    14
    MAY 15, 2024 | 9:00 AM
    Unveiling Tumor Immune Landscape: Using Multiplexed Whole-Tissue Imaging and AI-Powered Spatial Analysis
    Unveiling Tumor Immune Landscape: Using Multiplexed Whole-Tissue...
    Immunotherapies, including immune checkpoint inhibitors, have emerged as promising treatments for advanced cancers. However, a subset of patients exhibits resistance to such therapies, and t...
    Speaker: Vasundhara Agrawal
    Sponsored By: Leica Microsystems
    17
    APR 30, 2024 | 10:30 AM
    C.E. CREDITS
    Keynote Presentation: Engineering Metabolically Fit, Memory-Rich CAR T cells for Treatment of Cancer with Live Q&A
    Keynote Presentation: Engineering Metabolically Fit, Memory-Rich...
    Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieve a durable complete response. Furthermore,...
    Speaker: Sarwish Rafiq, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2024
    2
    On Demand
    C.E. CREDITS
    Immunomechanics and Mechano-Immunology in Brain Cancer
    Immunomechanics and Mechano-Immunology in Brain Cancer
    Brain cancer research stands to benefit from the perspectives, tools, and methodologies of non-traditional fields, such as mechanical engineering. Here, I will discuss our engineering-based...
    Speaker: Meenal Datta, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2024
    2
    On Demand
    C.E. CREDITS
    Investigating the Spatial Organization of the Immune Response in Tumors: Insights from the STAMP Model
    Investigating the Spatial Organization of the Immune Response...
    Understanding the spatial organization of the immune response within tumors is crucial for developing effective cancer immunotherapies. In this seminar, we delve into the interactions betwee...
    Speaker: Kate Carbone, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2024
    3
     
     
  • On Demand
    C.E. CREDITS
    Engineering T Cells to Stimulate Endogenous Antitumor Immunity
    Engineering T Cells to Stimulate Endogenous Antitumor Immunity
    Adoptive cell therapy (ACT) is an immunotherapy that employs living immune cells to target and destroy cancer cells. However, the inhibitory tumor microenvironment features several obstacles...
    Speaker: Shannon K. Oda, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2024
    3
    APR 10, 2024 | 9:00 AM
    Linking spatial and temporal profiling to clinical settings through advanced machine learning
    Linking spatial and temporal profiling to clinical settings through...
    Leveraging advancements in spatially resolved single-cell profiling, our study enhances understanding of glioma evolution and the complex tumor microenvironment. Through spatially resolved m...
    Speaker: Carole Chedid, Ph.D , Univ.-Prof. Dr. med. Dieter Henrik Heiland
    Sponsored By: Vizgen
    13
    MAR 13, 2024 | 8:00 AM
    Spatial Protein and RNA Profiling: Seeing the Unseen in the Tumor Microenvironment
    Spatial Protein and RNA Profiling: Seeing the Unseen in the Tumor...
    Our presenter Jonathan Nowak, will discuss representative multiplexed assays for protein and RNA profiling built in the lab and discuss the necessary elements to operationalize this type of...
    Speaker: Jonathan Nowak MD, Ph.D.
    Sponsored By: Leica Biosystems
    14
    FEB 21, 2024 | 7:30 AM
    C.E. CREDITS
    Keynote Presentation: High-Throughput Interrogation of the Tumor Microenvironment Using Digital Image Analysis
    Keynote Presentation: High-Throughput Interrogation of the Tumor...
    Multiplex immunofluorescence is a powerful tool for phenotyping cells from a single tissue slide, while preserving spatial context. The MultiOmyxTM platform, offered as an end to end service...
    Speaker: Harry Nunns
    Presented at: Drug Discovery & Development Virtual Event Series 2024
    2
    On Demand
    C.E. CREDITS
    Validation of a hyperplex assay for single cell spatial analysis of multiple protein and RNA biomarkers within the tumor microenvironment (TME)
    Validation of a hyperplex assay for single cell spatial analysis...
    Spatial analysis of protein or gene expression is vital to understanding the distribution, phenotypes, and interactions between cells within tumor microenvironment (TME). Traditionally, mult...
    Speaker: Courtney Todorov, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2024
    2
     
     
  • NOV 07, 2023 | 10:00 AM
    Understanding the Mechanisms of Resistance in CAR T Immunotherapy for Lymphoma and Strategies to Overcome Them
    Understanding the Mechanisms of Resistance in CAR T Immunotherapy...
    In the last 5 years, the US Food and Drug Administration has approved 4 anti-CD19 chimeric antigen receptor T cell (CART19) products for relapsed/refractory B cell lymphomas and leukemia. Ho...
    Speaker: Marco Ruella
    Sponsored By: Beckman Coulter Life Sciences
    22
    OCT 10, 2023 | 10:00 AM
    From Tissue to Insight: Genomic Testing Methodologies and Practical Considerations for Personalized Cancer Care
    From Tissue to Insight: Genomic Testing Methodologies and Practical...
    For patients with advanced non-small cell lung cancer (NSCLC), tissue samples are typically small biopsies. These samples undergo standard of care evaluation for >10 biomarkers to identif...
    Speaker: Kyle Strickland, MD, PhD , Rebecca Previs, MD
    Sponsored By: Labcorp Oncology
    29
    On Demand
    Multifaceted Community Analyses Uncover Novel Bacterial Species in the Colorectal Tumor Niche
    Multifaceted Community Analyses Uncover Novel Bacterial Species...
    The tumor-associated microbiota is an inherent component of the tumor microenvironment across various human cancer types1. Although members of tumor-associated microbiomes can be identified...
    Speaker: Martha Zepeda Rivera, PhD
    Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2023
    3
    On Demand
    Reprogramming Natural Killer Cells for Cancer Immunotherapy
    Reprogramming Natural Killer Cells for Cancer Immunotherapy
    Natural killer (NK) cells, immune cells with an innate ability to recognize and eliminate cancer cells, have emerged as attractive effectors in immunotherapy, owing in large part to their ab...
    Speaker: Sandro Matosevic, PhD
    Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2023
    4
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