JAN 08, 2018 08:03 AM PST

Treatment Strategies for Multidrug-resistant Chronic Infections

WRITTEN BY: Carmen Leitch

Cystic-fibrosis (CF) patients have enough problems, by they are also often plagued by antibiotic-resistant infections with Pseudomonas bacteria. These infections are apparently susceptible to certain classes of antibiotics. A new study reported in Cell by researchers at the Novo Nordisk Foundation Center for Biosustainability of the Technical University of Denmark suggested that this work may help doctors optimize the treatment of chronic infections for individual patients.

Research paves the way for new rational treatment strategies of multidrug-resistant chronic infections.  / Credit: Christian Als/ The Novo Nordisk Foundation Center for Biosustainability at the Technical University of Denmark

"Our discovery of widespread antibiotic sensitivities in the multidrug-resistant pathogen Pseudomonas aeruginosa opens up the opportunity to limit the development of antibiotic resistance and perhaps even revert it. This could be important for the treatment of several chronic infections including the life-long lung infections of patients with cystic fibrosis," noted Morten Sommer, Professor and Scientific Director at the Novo Nordisk Foundation Center for Biosustainability.

The scientists discovered that some vulnerabilities to antibiotics are maintained in multidrug-resistant pathogens across clinical isolates obtained over many years at the Cystic fibrosis clinic in Rigshospitalet in Copenhagen. The analysis revealed the mutations that caused these sensitivities, as well.

"Targeting vulnerabilities of phenotypic states related to specific mutations could potentially have a huge impact because it makes it possible to make a more personalized treatment strategy for each patient,” explained Lejla Imamovic, Senior Researcher at the Novo Nordisk Foundation Center for Biosustainability.

"Results indicate that for some antibiotics, exposure and subsequent resistance evolution leads to convergence toward specific phenotypes states. Thus, collateral sensitivity may be particularly useful for optimizing treatments of chronic infections since their nature and severity warrants and requires tailored treatment strategies," said Lejla Imamovic.

Scientific knowledge is one thing, but usefulness in the clinic is another. Currently, it is thought that pathogens evolve, becoming increasingly resistant in response to antibiotic treatment, causing a chronic infection. However, widespread collateral sensitivity interactions suggest that chronically infectious bacteria have fluctuating resistance profiles in response to different drugs, according to Sommer.

"Our research supports the notion that treatment of chronically infected patients could be significantly improved based on specific diagnostic markers that are associated with a collateral sensitivity to specific drugs," he said. Now, the findings have to be applied to the patient.

"Actually, some of our findings relate to drugs that are already used clinically and it is possible that benefits can be gained simply by making slight changes to the empirical treatment prescribed by physicians already now. Yet, larger controlled clinical trials will also be important in order to fully exploit these findings in the clinic," noted Morten Sommer.

Learn more about Pseudomonas infections in CF from this video.
 


Soucres: AAAS/Eurekalert! Via Technical University of Denmark, Cell

About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
OCT 21, 2018
Genetics & Genomics
OCT 21, 2018
The Genetic Cause of Severe Childhood Epilepsy is Revealed
This work has opened up new therapeutic avenues that the scientists will be exploring....
OCT 29, 2018
Neuroscience
OCT 29, 2018
Gut: a second brain and novel therapeutic target
Undersatnding the role of gut microbiome in disease pathologies and targetting them for potential treatment strategies....
NOV 03, 2018
Genetics & Genomics
NOV 03, 2018
Stopping a Jumping Gene Invasion
Researchers have found that stem cells can react when transposons invade the genome....
NOV 13, 2018
Cell & Molecular Biology
NOV 13, 2018
The Mechanism of a Cell-penetrating Peptide is Revealed
Cells have a barrier around them, which carefully controls what can move across it. That presents a challenge in pharmaceutical design....
DEC 06, 2018
Cell & Molecular Biology
DEC 06, 2018
Exploiting a Cell's Love of Zinc to Deliver Targeted Therapeutics
With insulin costs rising, the development of alternative treatments for diabetes is becoming a pressing matter....
DEC 07, 2018
Microbiology
DEC 07, 2018
Epigenetic Inheritance is Revealed in Archaea
Researchers may have found a great new way to study tags that are added to the genome, which change how genes are expressed....
Loading Comments...