MAR 17, 2016 12:00 PM PDT

Keynote Speaker - Animal models in psychiatry research

Presented at: Neuroscience
Speaker
  • Senior Research Fellow and Head of Psychiatry Discovery Research in CNS for the Neuroscience & Pain Research Unit at Pfizer, Inc.
    Biography
      Patricio O'Donnell is a Senior Research Fellow and Head of Psychiatry Discovery Research in CNS for the Neuroscience & Pain Research Unit at Pfizer, Inc. in Cambridge, Ma. Dr. O'Donnell grew up in Buenos Aires, Argentina and earned his M.D. and Ph.D. degrees from the University of Buenos Aires. Dr. O'Donnell worked as a postdoctoral fellow with Anthony Grace at the University of Pittsburgh, where he pioneered studies on the physiological properties of the nucleus accumbens, and then moved on to establishing his own research program at Albany Medical College. In 2006 he was recruited by the University of Maryland, and in 2013 he moved to Pfizer. Dr. O'Donnell's research focuses on the modulation of cortical brain circuits by dopamine, how this modulation matures during adolescence, and the mechanisms by which it becomes dysfunctional in rodent models of psychiatric disorders with the goal of identifying novel therapeutic targets. He is the recipient of numerous awards including the 2010 National Alliance for Schizophrenia and Depression Distinguished Investigator Award. Dr. O'Donnell is a fellow in the American College of Neuropsychopharmacology (ACNP), chaired several conferences including the 2009 Gordon Conference on Catecholamines and is currently the chair of the Winter Conference on Brain Research. Dr. O'Donnell has authored over 80 scientific papers, served or serves on the Editorial Boards of the Journal of Neuroscience, Neuropsychopharmacology, The International Journal of Neuropsychopharmacology, Schizophrenia Bulletin, and the Journal of Pharmacology & Experimental Therapeutics, among others, and sat on advisory committees of the National Institutes of Health. He serves on the scientific advisory board of several private foundations and has advised major pharmaceutical and biotech companies. Before joining Pfizer, Dr. O'Donnell was a Professor of Anatomy & Neurobiology and Psychiatry at the University of Maryland School of Medicine.

    Abstract

    Schizophrenia, depression, bipolar disorder are all uniquely human conditions.  Psychiatric conditions include alterations in several different and overlapping domains (NIMH RDoC). Each domain may have unique biological bases. Drug development efforts are now based on addressing domains/RDoC.  Can we model psychiatric conditions in rodents? Schizophrenia, depression, bipolar disorder are all uniquely human conditions. Psychiatric conditions include alterations in several different and overlapping domains (NIMH RDoC).  Each domain may have unique biological bases. Drug development efforts are now based on addressing domains/RDoC.


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