OCT 11, 2018 12:00 PM PDT

Lung Cancer Evolution and Immune Escape

Speaker

Abstract

Lung cancer is the leading cause of cancer-related mortality worldwide. Large-scale sequencing studies have revealed the complex genomic landscape of NSCLC and genomic differences between lung adenocarcinomas (LUAD) and lung squamous cell carcinomas (LUSC). However, in-depth exploration of NSCLC intratumor heterogeneity and cancer genome evolution has been limited to small retrospective cohorts. As such, the clinical significance of ITH and the potential for clonality of driver events to guide therapeutic strategies is not yet defined.

In this talk I will outline how intra-tumor heterogeneity can be deciphered using multi-region sequencing. I will examine how heterogeneity can be utilized to gain a deeper understanding of tumor evolution, focusing on results from the TRACERx  (TRAcking non-small cell lung Cancer Evolution through therapy (Rx)) study.

I will explore the clinical implications of intra-tumor heterogeneity and consider clinical approaches to tackle this devastating disease. 

Learning Objectives: 

1. Tumour heterogeneity is widespread in early stage NSCLC and occurs at both mutational and copy number level
2. APOBEC-mediate mutagenesis occurs later in lung cancer evolution and is associated with subclonal expansions
3. HLA LOH is a pervasive mechanisms of immune evasion. 


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OCT 11, 2018 12:00 PM PDT

Lung Cancer Evolution and Immune Escape


Specialty

Cancer

Cancer Research

Cancer Diagnostics

Oncology

Pcr/rt-Pcr/real-Time Pcr

Bioinformatics

Research And Development

Personalized Medicine

Gene Expression

Molecular Biology

Lab Safety

Human Behavior

Tumor

Molecular Diagnostics

Human Genetics

Geography

North America45%

Asia27%

Europe18%

Africa9%

Registration Source

Website Visitors100%

Job Title

Student20%

Medical Laboratory Technician20%

Research Scientist20%

Pharmacist10%

Clinical Laboratory Scientist10%

Executive10%

Scientist10%

Organization

Hospital18%

Clinical Laboratory18%

Academic Institution9%

Manufacturer - Other9%

Biotech Company9%

Contract Research Organization (Cro)9%

Government9%

Other18%


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