AUG 08, 2018 8:00 AM PDT

Lupus Anticoagulant Testing: Managing Interferences and Optimizing Quality

Sponsored by: Diagnostica Stago, Inc.
Speaker
  • Assistant Professor in the Department of Pathology, Interim Director of Blood Bank, and Associate Director of Coagulation Laboratory at the University of Chicago Medical Center
    Biography
      Dr Geoffrey Wool is assistant professor in the department of pathology, Interim Director of Blood Bank, and Associate Director of Coagulation Laboratory at the University of Chicago Medical Center. Prior to his current positions, he completed his fellowship in transfusion medicine at University of Chicago, fellowship in hematopathology at University of California San Francisco, and was a resident physician in the department of pathology and laboratory medicine. He earned an MD and PhD from University of Chicago and a BA from University of California, Berkeley. Dr Wool has published 18 peer-reviewed publications in areas of lupus anticoagulant testing, anticoagulant monitoring, platelet defects, and transfusion medicine, is a reviewer for multiple journals, has written several educational book chapters on different areas of pathology, as well as attending numerous research conferences where he presented oral or poster presentations.

    Abstract

    Antiphospholipid syndrome (APS) is an autoimmune acquired thrombophilic disorder which is diagnosed based on clinical and laboratory criteria; of the laboratory criteria, a positive lupus anticoagulant (LA) is one of the best predictors of thrombotic risk in APS.

    Laboratory testing for APS, as well as the accurate reporting of the data, is complicated and is governed by multiple guidelines from national and international organizations. Given that LA testing is clot-based, anticoagulants and factor deficiencies can significantly interfere with accurate testing; the choice of LA testing reagents can help limit the impact of these interferences. One laboratory's experience optimizing LA testing and APS reporting will be discussed, with interesting cases reviewed.

    Learning Objectives:

    • Review international guidelines for antiphospholipid syndrome (APS) laboratory diagnosis and reporting
    • Examine lupus anticoagulant biochemistry
    • Share our laboratory’s improvements in our APS testing reagents, workflow, and turn-around time of comprehensive APS reports
    • Learn from some interesting APS cases showing common and rare LA interferences

     


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