OCT 11, 2018 6:00 AM PDT

Revealing the Hidden Landscape of Structural Variants in Cancer Genomes

Speaker
  • Chief Scientific Officer, Pacific Biosciences
    Biography
      Jonas Korlach was appointed Chief Scientific Officer of Pacific Biosciences in July 2012. He was previously a Scientific Fellow, supporting commercial development of the PacBio RS II system and performing research aimed at developing new applications for SMRT technologies. He co-invented the SMRT technology with Stephen Turner, Ph.D., Pacific Biosciences Founder and Chief Technology Officer, when the two were graduate students at Cornell University.

      Dr. Korlach joined Pacific Biosciences as the company's eighth employee in 2004. Previously, he was a Postdoctoral Researcher at Cornell University. Dr. Korlach is the recipient of multiple grants, an inventor on 70 issued U.S. patents and 61 international patents, and an author of over 100 scientific studies on the principles and applications of SMRT technology, including publications in Nature, Science, and PNAS. In 2013, Dr. Korlach was honored by the Obama White House as an Immigrant Innovator "Champion of Change." He received both his Ph.D. and his M.S. degrees in Biochemistry, Molecular and Cell Biology from Cornell, and received M.S. and B.A. degrees in Biological Sciences from Humboldt University in Berlin, Germany.

    Abstract

    PacBio Sequencing simultaneously provides long sequence reads, high consensus accuracy, minimal sequence bias, and methylation detection. I will highlight new advances and updates on applying PacBio sequencing in cancer research, including targeted sequencing, genome-wide structural variant detection and de novo assembly of cancer genomes. Other topics presented will include full-length RNA sequencing (Iso-Seq) for the detection of gene fusions and cancer-related transcript splice isoforms, and how high-accuracy single-molecule consensus reads (through a process called circular consensus sequencing (CCS)), a capability unique to PacBio sequencing technology, can be leveraged for high-resolution, phased minor variant analysis. 

    Learning Objectives: 

    1. Learn about new methods to detect larger-scale genetic variants in cancer genomes
    2. Understand the utility of long-read PacBio sequencing for long-distance phasing of variants
    3. Get familiar with full-length RNA-seq (Iso-Seq) for the detection of gene fusions and cancer-related transcript splice isoforms


    Show Resources
    You May Also Like
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    OCT 11, 2018 6:00 AM PDT

    Revealing the Hidden Landscape of Structural Variants in Cancer Genomes


    Specialty

    Cancer Research

    Bioinformatics

    Gene Expression

    Cancer Diagnostics

    Molecular Genetics

    Cell Culture

    Research

    Cannabis Medicine

    Virology

    Lab Safety

    Brain

    Immunology

    Pcr/rt-Pcr/real-Time Pcr

    Cancer Genomics

    Drug Discovery

    Geography

    North America40%

    Europe40%

    Asia20%

    Registration Source

    Website Visitors100%

    Job Title

    Student50%

    Medical Laboratory Technician25%

    Post Doc25%

    Organization

    Academic Institution40%

    Manufacturer - Other20%

    Research Institute20%

    Other20%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more