Kadoch completed her graduate studies at the Stanford University School of Medicine. Working alongside renowned developmental biologist Gerald Crabtree, she used a series of biochemical experiments to identify a novel set of protein components of the mSWI/SNF or BAF complex, which regulate chromatin structure. Upon these discoveries, Kadoch and her colleagues then linked mutations in the subunits of BAF complexes to more than one-fifth of human cancers-a number which continues to rise in light of increasingly completed sequencing efforts in human disease. In addition, she worked to uncover the oncogenic mechanism of BAF complex perturbation in a rare, aggressive soft-tissue sarcoma, known as synovial sarcoma. Kadoch is now developing new approaches to the structural and functional interrogation of chromatin regulators and developing therapeutic approaches for cancers driven by BAF mutations.
Kadoch earned her undergraduate degree in Molecular and Cell Biology from the University of California, Berkeley, and her Ph.D. in Cancer Biology from the Stanford University School of Medicine. In 2014, shortly before becoming one of the youngest Assistant Professors ever appointed to the faculty of Harvard Medical School, she was named to Forbes Magazine's 30 Under 30 in Science & Healthcare, and in 2015, the MIT Technology Review Top Innovators Under 35. Among numerous awards, she is the recipient of the NIH Director's New Innovator Award, the American Cancer Society Research Scholar Award, and was recently named a Pew-Stewart Scholar in Cancer Research.