SEP 19, 2017 10:30 AM PDT

WEBINAR: Structure and Function of Epigenetic Regulators in Human Disease

Speakers
  • Assistant Professor of Pediatric Oncology at the Dana-Farber Cancer Institute and Harvard Medical School and an Institute Member of the Broad Institute of MIT and Harvard
    BIOGRAPHY
  • Director, Product Development at Cell Signaling Technology
    BIOGRAPHY

Abstract

DATE: September 19, 2017
TIME: 10:30am PDT/ 1:30pm EDT/ 7:30pm CEST


Part 1 – Cigall Kadoch, Ph.D. (30 min.)

Exome- and genome-wide sequencing studies in human cancer have revealed a striking frequency of mutations in the genes encoding subunits of the mammalian SWI/SNF (BAF) family of ATP-dependent chromatin remodeling complexes. We recently determined these mutations to be broadly recurrent in over 20% of all cancers. I will present studies focused on the assembly and topological architecture of mammalian SWI/SNF complexes, cancer-specific complex subunit and associated protein factor composition, and novel approaches toward the identification of small molecule therapeutics for this class of human tumors.

Part 2 – Chris Fry, Ph.D. (30 min.)

The robustness and reliability of chromatin immunoprecipitation (ChIP) and ChIP-seq data is highly dependent on the quality of the antibodies and chromatin preparation used in the immunoprecipitation. I will provide an overview of the development and validation of new high quality recombinant rabbit monoclonal antibodies that show improved specificity, sensitivity, and reproducibility in ChIP and ChIP-seq assays. In addition, I will discuss important factors to consider for optimizing different types of target proteins, including histones, transcription factors, and transcription cofactors.

 

Learning Objectives:

  • The assembly and biological architecture of mammalian SWI/SNF complexes..
  • The role of cancer-specific SWI/SNF complex mutations (present in 20% of cancers) in driving oncogenicity.
  • Novel approaches toward the identification of small molecule therapeutics for this class of human tumors.
  • Development and validation of new high quality recombinant monoclonal antibodies for ChIP and ChIP-seq.
  • Important factors to consider for optimizing different types of proteins – including histones, transcription factors, and cofactors – for ChIP.
     

 


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SEP 19, 2017 10:30 AM PDT

WEBINAR: Structure and Function of Epigenetic Regulators in Human Disease


Specialty

Molecular Biology

Cancer Research

Genetics

Cell Biology

Molecular Diagnostics

Immunology

Biotechnology

Biochemistry

Genomics

Gene Expression

Biomarkers

Cancer Diagnostics

Bioinformatics

Cell Culture

Cancer Therapeutics

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North America54%

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Asia14%

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Oceania1%

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Website Visitors100%

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Student22%

Research Scientist16%

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Post Doc7%

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Scientist6%

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Facility/Department Manager5%

Clinical Laboratory Scientist2%

Biologist2%

Chemist1%

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Academic Institution17%

Research Institute6%

Clinical Laboratory5%

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Consultant1%

Non-Profit Organization1%

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