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Learning Objectives: 1. Background introduction to AAV gene therapy 2. Novel methods to build AAV capsid libraries for in vivo screening through rational design and directed evolution 3. Tis...
Genome editing technologies have enabled the precise manipulation of DNA sequences at targeted sites to achieve therapeutic effects. Engineered endonucleases like CRISPR-Cas9 institute site-...
Biocatalysis, protein engineering, and flow chemistry are key enabling technologies that can yield drastically shorter and greener chemical processes. We sought to leverage these technologie...
Learning Objectives: 1. Delivery vehicles for the Cas9 RNP 2. Gene editing after a direct tissue injection 3. New linkers for conjugating proteins to polymers...
AAV peptide display libraries allow for the generation of novel variants capable of high-level transduction. We previously described an AAV peptide display library combined with a sensitive...
Learning Objectives: 1. CRISPR-Cas systems are naturally repurposes for non-canonical functions other than cleaving RNA and DNA 2. CRISPR RNA-guided transposases integrate donor DNA without...
Genome Engineering allows the easy manipulation of genomes down to the nucleotide level. CRISPR is a revolutionizing tool for generating custom edited cell and pre-clinical animal models for...
We have harnessed homologous recombination to modify the genome of human stem cells with high frequencies (>40%). By designing the recombination donor in different ways, we can achieve a...
Though AsCas12a fills a crucial gap in the current genome editing toolbox, it exhibits relatively poor editing efficiency, restricting its overall utility. In collaboration with Integrated D...
Gene editing technologies such as CRISPR/Cas9 have greater flexibility and high efficiency. CRISPR technology enables targeted insertion of transgenes at the desired locus and has the abilit...
T-cells targeting shared oncogenic mutations can induce durable tumor regression in epithelial cancer patients. Such T cells can be detected in tumor-infiltrating lymphocytes and peripheral...
Human T cells are critical effectors of immune protection from infections, autoimmune pathology, and cancer immunotherapy. We use CRISPR-mediated gene editing in primary human T cells to sys...
Date: July 20, 2021 Time: 10:00am PDT From raw material identification to finished and packaged pharmaceutical products, stability testing is a critical step for both research and developmen...
Date: July 20, 2021 Time: 8:00am (PDT), 11:00am (EDT) The FDA released their guidance, Bacterial Risk Control Strategies for Blood Collection Establishments and Transfusion Services to Enhan...
Date: July 20, 2021 Time: 7:00am (PDT), 10:00am (EDT) Patient blood management is an evidence-based, multidisciplinary approach to caring for patients who might need a blood transfusion (1)...
Date: July 15, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Sigma Metrics plays a critical role in laboratory medicine. Abbott is committed to helping your laboratory achieve excellence in clinica...
Date: July 14, 2021 Time: 9:00am PDT Health economic evaluations are used to inform decision-making in healthcare as they aim to assess the impact of new health interventions, technologies,...
Date: July 8, 2021 Time: 8:00am (PDT) Cell-based chimeric antigen receptor (CAR) T cell therapies have rapidly advanced in recent years, with a variety of targets in clinical research and se...
Date: July 01, 2021 Time: 09:30am IST/12:00pm SGT/01:00pm JST, KST/03:00pm AEST/ 05:00pm NZST We know that understanding cell culture is essential for life of your work. Gibco Galaxy Tour We...
Quality control results are flagged on a daily basis, and each lab may have different procedures to resolve the issue. As bench technologists are faced with an abrupt stop to their workflow...
Date: June 30, 2021 Time: 7:00am (PDT), 8:00am (EDT) Join us to discover how Optical genome mapping (OGM) mapping can help you in the characterization of complex samples. OGM is a non-sequen...
Date: June 29, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Freeze-fracture and freeze-etching are useful tools for studying flexible membrane-associated structures such as tight junctions or the...
Date: June 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) SARS-CoV-2 continues to evolve and surveillance of variants is a necessity. Routine analysis of genetic sequence data allows the identif...