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    Cancer Molecular Biology

    Molecular biology plays an important role in the diagnosis and treatment of cancer. On a biological level, the development of cancer is characterized by the acquisition of genetic mutations which cause abnormal cell growth, eventually resulting in malignant disease. Understanding how molecular damage can cause these cancer-driving mutations can help design optimal treatment regimens

    Webinars

    • SEP 23, 2020 | 4:30 PM
      Anatomy of a nucleic acid sample preparation
      Anatomy of a nucleic acid sample preparation
      There are many methods of nucleic acid isolation. Each technology offers different approaches of purification of the template. However, it is important to control carry over of “proces...
      Speaker: Katherine Mechling
      Presented at: Cell Biology Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      2 1
      SEP 23, 2020 | 3:00 PM
      Beyond the Culture Flask: How Membrane- and Microfluidic-based Platforms can create more Physiologically Relevant Tissue Culture Systems
      Beyond the Culture Flask: How Membrane- and Microfluidic-based...
      For more than a century, breakthroughs in biological sciences have relied on the ability to study cells outside of respective organisms. While majority of cell culturing is still performed u...
      Speaker: Jun Park, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      1
      SEP 23, 2020 | 1:30 PM
      Analytic Options for Mass Cytometry Data
      Analytic Options for Mass Cytometry Data
      From data to insight: Explore the full potential of high dimensional data by leveraging machine learning algorithms 1:30–2:00 pm PDT Presented By: Qianjun Zhang, MS Utilizing FCS Expre...
      Speaker: Qianjun Zhang, MS , Sean Burke, MS , Thiru Selvanantham, PhD , Beth Lindroth Hill, PhD , Jared K. Burks, PhD , Trevor McKee, PhD , Donald Allen, BS
      Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
      1
      SEP 23, 2020 | 1:30 PM
      Keynote Presentation: Starting at the source: tissue extracellular vesicles and Alzheimer's disease
      Keynote Presentation: Starting at the source: tissue extracellular...
      Extracellular vesicles (EVs) are lipid bilayer-delimited pieces of cells that are released from the plasma membrane as "ectosomes" and from the endosomal system as "exosomes.&...
      Speaker: Kenneth W. Witwer, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 23, 2020 | 12:00 PM
      Keynote Presentation: Sorting out the mechanisms of endocytic recycling
      Keynote Presentation: Sorting out the mechanisms of endocytic...
      Extracellular ligands bind to receptors on the cell surface leading to receptor internalization. Once internalized into small vesicles, the vesicles fuse with an organelle known as the sorti...
      Speaker: Steve Caplan, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 23, 2020 | 12:00 PM
      Mass Cytometry in Translational Research: Session II
      Mass Cytometry in Translational Research: Session II
      B cells and tertiary lymphoid structures (TLS) promote immunotherapy response 1:00–1:30 pm PDT Presented By: Rafet Basar, MD...
      Speaker: Handan Xiang, PhD , Pei-Yu Chen, PhD , Hiranmayi Ravichandran, MS , Rafet Basar, MD , Amir Horowitz, PhD
      Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
      2
      SEP 23, 2020 | 10:30 AM
      iPSC- and patient- derived intestinal organoids for gastrointestinal research
      iPSC- and patient- derived intestinal organoids for gastrointestinal...
      Intestinal organoids are self-organizing, 3D structures derived from either pluripotent stem cells or from primary tissues with the abiltiy to recapitulate some of the spatial architecture a...
      Speaker: Kevin Su
      Presented at: Cell Biology Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      2
      SEP 23, 2020 | 10:30 AM
      New Insights Gained with Imaging Mass Cytometry
      New Insights Gained with Imaging Mass Cytometry
      Speaker TBD 10:30–10:50 am PDT Exploring the immune tumor microenvironment of hepatocellular carcinoma with Imaging Mass Cytometry™ 10:50 am–11:10 am PDT Presented By: Won...
      Speaker: Won Jin Ho, MD , Melissa B. Davis, PhD
      Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
      1
      SEP 23, 2020 | 9:00 AM
      Keynote Presentation: Extracellular vesicles in Regenerative Medicine
      Keynote Presentation: Extracellular vesicles in Regenerative Medicine
      Extracellular vesicles (EVs) are nanosized vesicles containing active proteins, lipids, and different types of genetic material such as non coding RNA species, related to the characteristics...
      Speaker: Benedetta Bussolati, MD, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      2
      SEP 23, 2020 | 7:30 AM
      Cell Culture Troubleshooting Tips and Tricks
      Cell Culture Troubleshooting Tips and Tricks
      Cell culture continues to be a critical tool for most life science research and applications. From HeLa to iPSCs and 3D to organoids, culture methods have become more advanced and techniques...
      Speaker: Marina Wiklander, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      6
      SEP 23, 2020 | 6:00 AM
      Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate the biology of the Tumor Microenvironment
      Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate...
      MicroRNAs (miRs) are small non-coding RNAs whose expression is altered in several types of human cancers. Recent evidence supports their inter-cellular transfer through extracellular vesicle...
      Speaker: Muller Fabbri, MD, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      2
      SEP 23, 2020 | 12:00 AM
      Transcriptomic signature : a spatially resolved analysis of the nephron structures in chronic kidney disease
      Transcriptomic signature : a spatially resolved analysis of the...
      Chronic kidney disease (CKD) is a global health threat, affecting over 10% of the world population, including an estimated 37 million Americans. Importantly, glomerular diseases account for...
      Speaker: Paolo Cravedi, MD, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      2
      SEP 23, 2020 | 12:00 AM
      The role of Nox-derived Reactive Oxygen Species in Axonal Growth and Guidance
      The role of Nox-derived Reactive Oxygen Species in Axonal Growth...
      Reactive oxygen species (ROS) are well-known for their detrimental effects leading to oxidative stress, cell death, aging, and degenerative disorders. However, there is increasing evidence t...
      Speaker: Daniel M. Suter, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      2
      SEP 23, 2020 | 12:00 AM
      Deep learning to integrate histology with spatial transcriptomics
      Deep learning to integrate histology with spatial transcriptomics
      I will present our new computer vision algorithm, ST-Net, which can computationally synthesize spatially resolved transcriptomics directly from H&E histology images (He et al. Nature Bio...
      Speaker: James Zou
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 23, 2020 | 12:00 AM
      GeoMx Digital Spatial Profiling read-out for Next-Generation Sequencers with the Cancer Transcriptome Atlas (CTA)
      GeoMx Digital Spatial Profiling read-out for Next-Generation Sequencers...
      GeoMx Digital Spatial Profiling Technology! The GeoMx Digital Spatial Profiler (DSP) is a novel platform developed by NanoString. This leading digital technology offers multiplexed measureme...
      Speaker: Kit Fuhrman
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 23, 2020 | 12:00 AM
      Extracellular Matrix in Renal Development and Cancer
      Extracellular Matrix in Renal Development and Cancer
      The extracellular matrix (ECM) is a three-dimensional structure that provides physical support for tissues/organs and biochemical/biomechanical cues for tissue morphogenesis, differentiation...
      Speaker: Astgik Petrosyan, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      4
      SEP 23, 2020 | 12:00 AM
      Clinical Scale production extracellular vesicles from various cell types in a cGMP compatible 3-D Capillary Bioreactor: from culture dish to 3-D capillary bioreactor
      Clinical Scale production extracellular vesicles from various...
      Extracellular vesicles (EV) from many cell types have demonstrated therapeutic potential against many different diseases. Inhibiting progress in this area is the capability to produce EVs in...
      Speaker: John J.S. Cadwell
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 23, 2020 | 12:00 AM
      Extracellular Vesicles and Chronic Kidney Disease
      Extracellular Vesicles and Chronic Kidney Disease
      Chronic kidney disease (CKD) is a major public health threat, affecting 11-15% of the U.S. population alone. Currently, there are no effective therapies to cure CKD. Drug therapies are not p...
      Speaker: Sargis Sedrakyan, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 23, 2020 | 12:00 AM
      Current approaches for exosome processing and the emerging importance of subtyping
      Current approaches for exosome processing and the emerging importance...
      Learning Objectives: 1. Understand methods of isolating and enriching exosomes along with their pros/cons of the different techniques 2. What do we mean when we talk about subtyping, and wha...
      Speaker: Jim West III, MS, CEO
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 17, 2020 | 2:00 PM
      Keynote Presentation: The formation of an International Collaborative Network to find COVID-19 Therapeutics
      Keynote Presentation: The formation of an International Collaborative...
      Learning Objectives: 1. Understanding the integral value of collaboration for advancement in scientific research; how to establish and grow academic, Pharma, and industry connections 2. Lear...
      Speaker: Jacqueline Fabius , Nevan Krogan, PhD
      Presented at: Coronavirus Series
      1
      SEP 17, 2020 | 2:00 PM
      MAPK Activity Dynamics Regulate Non-Cell Autonomous Effects of Oncogene Expression
      MAPK Activity Dynamics Regulate Non-Cell Autonomous Effects of...
      Deregulation of Receptor Tyrosine Kinase (RTK) signaling underlies a large fraction of human cancers. These genetic perturbations lead to a variety of cell autonomous and non-cell autonomous...
      Speaker: Sergi Regot, MS, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      2
      SEP 17, 2020 | 12:00 AM
      Insights into SARS-CoV-2 Biology
      Insights into SARS-CoV-2 Biology
      As part of a large collaborative effort, we have used systems biology approaches to identify host factors that participate in SARS-CoV-2 replication. Protein-protein interactions maps betwee...
      Speaker: Adolfo Garcia-Sastre, PhD
      Presented at: Coronavirus Series
      5
      SEP 16, 2020 | 12:15 PM
      High-resolution HCA-based phenotypic profiling of tumor spheroids and organoids
      High-resolution HCA-based phenotypic profiling of tumor spheroids...
      Image-based high-content screening (HCS) involving cancer cell lines grown in conventional two-dimensional (2D) cell culture, has provided a cornerstone assay for searching new agents to tre...
      Speaker: Meritxell B. Cutrona, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      2
      SEP 16, 2020 | 9:00 AM
      Deep multi-omic phenotyping of biospecimens for immuno-oncology applications
      Deep multi-omic phenotyping of biospecimens for immuno-oncology...
      Date: September 16, 2020 Time: 9:00am PTD, 12:00pm EDT Harnessing the power of the host immune system to treat diseases has been transformational in patient care. Physiologically relevant ce...
      Speaker: Dr. Shawn Fahl
      Sponsored By: Miltenyi Biotec
      11
    SEP 23, 2020 | 4:30 PM
    Anatomy of a nucleic acid sample preparation
    Anatomy of a nucleic acid sample preparation
    There are many methods of nucleic acid isolation. Each technology offers different approaches of purification of the template. However, it is important to control carry over of “proces...
    Speaker: Katherine Mechling
    Presented at: Cell Biology Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    2 1
    SEP 23, 2020 | 3:00 PM
    Beyond the Culture Flask: How Membrane- and Microfluidic-based Platforms can create more Physiologically Relevant Tissue Culture Systems
    Beyond the Culture Flask: How Membrane- and Microfluidic-based...
    For more than a century, breakthroughs in biological sciences have relied on the ability to study cells outside of respective organisms. While majority of cell culturing is still performed u...
    Speaker: Jun Park, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    1
    SEP 23, 2020 | 1:30 PM
    Analytic Options for Mass Cytometry Data
    Analytic Options for Mass Cytometry Data
    From data to insight: Explore the full potential of high dimensional data by leveraging machine learning algorithms 1:30–2:00 pm PDT Presented By: Qianjun Zhang, MS Utilizing FCS Expre...
    Speaker: Qianjun Zhang, MS , Sean Burke, MS , Thiru Selvanantham, PhD , Beth Lindroth Hill, PhD , Jared K. Burks, PhD , Trevor McKee, PhD , Donald Allen, BS
    Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
    1
    SEP 23, 2020 | 1:30 PM
    Keynote Presentation: Starting at the source: tissue extracellular vesicles and Alzheimer's disease
    Keynote Presentation: Starting at the source: tissue extracellular...
    Extracellular vesicles (EVs) are lipid bilayer-delimited pieces of cells that are released from the plasma membrane as "ectosomes" and from the endosomal system as "exosomes.&...
    Speaker: Kenneth W. Witwer, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    1
    SEP 23, 2020 | 12:00 PM
    Keynote Presentation: Sorting out the mechanisms of endocytic recycling
    Keynote Presentation: Sorting out the mechanisms of endocytic...
    Extracellular ligands bind to receptors on the cell surface leading to receptor internalization. Once internalized into small vesicles, the vesicles fuse with an organelle known as the sorti...
    Speaker: Steve Caplan, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    1
     
     
  • SEP 23, 2020 | 12:00 PM
    Mass Cytometry in Translational Research: Session II
    Mass Cytometry in Translational Research: Session II
    B cells and tertiary lymphoid structures (TLS) promote immunotherapy response 1:00–1:30 pm PDT Presented By: Rafet Basar, MD...
    Speaker: Handan Xiang, PhD , Pei-Yu Chen, PhD , Hiranmayi Ravichandran, MS , Rafet Basar, MD , Amir Horowitz, PhD
    Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
    2
    SEP 23, 2020 | 10:30 AM
    iPSC- and patient- derived intestinal organoids for gastrointestinal research
    iPSC- and patient- derived intestinal organoids for gastrointestinal...
    Intestinal organoids are self-organizing, 3D structures derived from either pluripotent stem cells or from primary tissues with the abiltiy to recapitulate some of the spatial architecture a...
    Speaker: Kevin Su
    Presented at: Cell Biology Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    2
    SEP 23, 2020 | 10:30 AM
    New Insights Gained with Imaging Mass Cytometry
    New Insights Gained with Imaging Mass Cytometry
    Speaker TBD 10:30–10:50 am PDT Exploring the immune tumor microenvironment of hepatocellular carcinoma with Imaging Mass Cytometry™ 10:50 am–11:10 am PDT Presented By: Won...
    Speaker: Won Jin Ho, MD , Melissa B. Davis, PhD
    Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
    1
    SEP 23, 2020 | 9:00 AM
    Keynote Presentation: Extracellular vesicles in Regenerative Medicine
    Keynote Presentation: Extracellular vesicles in Regenerative Medicine
    Extracellular vesicles (EVs) are nanosized vesicles containing active proteins, lipids, and different types of genetic material such as non coding RNA species, related to the characteristics...
    Speaker: Benedetta Bussolati, MD, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    2
    SEP 23, 2020 | 7:30 AM
    Cell Culture Troubleshooting Tips and Tricks
    Cell Culture Troubleshooting Tips and Tricks
    Cell culture continues to be a critical tool for most life science research and applications. From HeLa to iPSCs and 3D to organoids, culture methods have become more advanced and techniques...
    Speaker: Marina Wiklander, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    6
     
     
  • SEP 23, 2020 | 6:00 AM
    Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate the biology of the Tumor Microenvironment
    Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate...
    MicroRNAs (miRs) are small non-coding RNAs whose expression is altered in several types of human cancers. Recent evidence supports their inter-cellular transfer through extracellular vesicle...
    Speaker: Muller Fabbri, MD, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    2
    SEP 23, 2020 | 12:00 AM
    Transcriptomic signature : a spatially resolved analysis of the nephron structures in chronic kidney disease
    Transcriptomic signature : a spatially resolved analysis of the...
    Chronic kidney disease (CKD) is a global health threat, affecting over 10% of the world population, including an estimated 37 million Americans. Importantly, glomerular diseases account for...
    Speaker: Paolo Cravedi, MD, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    2
    SEP 23, 2020 | 12:00 AM
    The role of Nox-derived Reactive Oxygen Species in Axonal Growth and Guidance
    The role of Nox-derived Reactive Oxygen Species in Axonal Growth...
    Reactive oxygen species (ROS) are well-known for their detrimental effects leading to oxidative stress, cell death, aging, and degenerative disorders. However, there is increasing evidence t...
    Speaker: Daniel M. Suter, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    2
    SEP 23, 2020 | 12:00 AM
    Deep learning to integrate histology with spatial transcriptomics
    Deep learning to integrate histology with spatial transcriptomics
    I will present our new computer vision algorithm, ST-Net, which can computationally synthesize spatially resolved transcriptomics directly from H&E histology images (He et al. Nature Bio...
    Speaker: James Zou
    Presented at: Cell Biology Virtual Event Series 2020
    1
    SEP 23, 2020 | 12:00 AM
    GeoMx Digital Spatial Profiling read-out for Next-Generation Sequencers with the Cancer Transcriptome Atlas (CTA)
    GeoMx Digital Spatial Profiling read-out for Next-Generation Sequencers...
    GeoMx Digital Spatial Profiling Technology! The GeoMx Digital Spatial Profiler (DSP) is a novel platform developed by NanoString. This leading digital technology offers multiplexed measureme...
    Speaker: Kit Fuhrman
    Presented at: Cell Biology Virtual Event Series 2020
    1
     
     
  • SEP 23, 2020 | 12:00 AM
    Extracellular Matrix in Renal Development and Cancer
    Extracellular Matrix in Renal Development and Cancer
    The extracellular matrix (ECM) is a three-dimensional structure that provides physical support for tissues/organs and biochemical/biomechanical cues for tissue morphogenesis, differentiation...
    Speaker: Astgik Petrosyan, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    4
    SEP 23, 2020 | 12:00 AM
    Clinical Scale production extracellular vesicles from various cell types in a cGMP compatible 3-D Capillary Bioreactor: from culture dish to 3-D capillary bioreactor
    Clinical Scale production extracellular vesicles from various...
    Extracellular vesicles (EV) from many cell types have demonstrated therapeutic potential against many different diseases. Inhibiting progress in this area is the capability to produce EVs in...
    Speaker: John J.S. Cadwell
    Presented at: Cell Biology Virtual Event Series 2020
    1
    SEP 23, 2020 | 12:00 AM
    Extracellular Vesicles and Chronic Kidney Disease
    Extracellular Vesicles and Chronic Kidney Disease
    Chronic kidney disease (CKD) is a major public health threat, affecting 11-15% of the U.S. population alone. Currently, there are no effective therapies to cure CKD. Drug therapies are not p...
    Speaker: Sargis Sedrakyan, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    1
    SEP 23, 2020 | 12:00 AM
    Current approaches for exosome processing and the emerging importance of subtyping
    Current approaches for exosome processing and the emerging importance...
    Learning Objectives: 1. Understand methods of isolating and enriching exosomes along with their pros/cons of the different techniques 2. What do we mean when we talk about subtyping, and wha...
    Speaker: Jim West III, MS, CEO
    Presented at: Cell Biology Virtual Event Series 2020
    1
    SEP 17, 2020 | 2:00 PM
    Keynote Presentation: The formation of an International Collaborative Network to find COVID-19 Therapeutics
    Keynote Presentation: The formation of an International Collaborative...
    Learning Objectives: 1. Understanding the integral value of collaboration for advancement in scientific research; how to establish and grow academic, Pharma, and industry connections 2. Lear...
    Speaker: Jacqueline Fabius , Nevan Krogan, PhD
    Presented at: Coronavirus Series
    1
     
     
  • SEP 17, 2020 | 2:00 PM
    MAPK Activity Dynamics Regulate Non-Cell Autonomous Effects of Oncogene Expression
    MAPK Activity Dynamics Regulate Non-Cell Autonomous Effects of...
    Deregulation of Receptor Tyrosine Kinase (RTK) signaling underlies a large fraction of human cancers. These genetic perturbations lead to a variety of cell autonomous and non-cell autonomous...
    Speaker: Sergi Regot, MS, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    2
    SEP 17, 2020 | 12:00 AM
    Insights into SARS-CoV-2 Biology
    Insights into SARS-CoV-2 Biology
    As part of a large collaborative effort, we have used systems biology approaches to identify host factors that participate in SARS-CoV-2 replication. Protein-protein interactions maps betwee...
    Speaker: Adolfo Garcia-Sastre, PhD
    Presented at: Coronavirus Series
    5
    SEP 16, 2020 | 12:15 PM
    High-resolution HCA-based phenotypic profiling of tumor spheroids and organoids
    High-resolution HCA-based phenotypic profiling of tumor spheroids...
    Image-based high-content screening (HCS) involving cancer cell lines grown in conventional two-dimensional (2D) cell culture, has provided a cornerstone assay for searching new agents to tre...
    Speaker: Meritxell B. Cutrona, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    2
    SEP 16, 2020 | 9:00 AM
    Deep multi-omic phenotyping of biospecimens for immuno-oncology applications
    Deep multi-omic phenotyping of biospecimens for immuno-oncology...
    Date: September 16, 2020 Time: 9:00am PTD, 12:00pm EDT Harnessing the power of the host immune system to treat diseases has been transformational in patient care. Physiologically relevant ce...
    Speaker: Dr. Shawn Fahl
    Sponsored By: Miltenyi Biotec
    11
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