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    Clinical methods

    Clinical methods describe the techniques and analyses used to collect, process, and analyze clinical data. Clinical methods are used to reach a conclusion about a patient in a medical situation. There are various goals that can be achieved by following clinical methods, including diagnosing a disease, planning a treatment regimen, or monitoring the efficacy of a treatment

    Webinars

    • DEC 01, 2021 | 8:00 AM
      Resolving Challenges in Cell Media Culture Presentation
      Resolving Challenges in Cell Media Culture Presentation
      Date: December 01, 2021 Time: 8:00am (PDT), 11:00am (EDT) Discover how taking a holistic approach can help simplify and improve your cell culture media process workflows. In a discussion wit...
      Speaker: Michael De La Cruz, Ph.D.
      Sponsored By: FUJIFILM Irvine Scientific
      9
      NOV 30, 2021 | 11:00 AM
      Clinical value of measurable residual disease assessment in multiple myeloma
      Clinical value of measurable residual disease assessment in multiple...
      Date: November 30, 2021 Time: 11:00am (PDT), 2:00pm (EDT) In the recent years, measurable residual disease (MRD) assessment on multiple myeloma patients has gained increasing relevance. After...
      Speaker: Juan Flores-Montero, MD, PhD
      Sponsored By: Cytognos
      15
      NOV 30, 2021 | 10:00 AM
      The Role of the Laboratory in Managing Thyroid Health
      The Role of the Laboratory in Managing Thyroid Health
      Date: November 30, 2021 Time: 10:00am (PDT), 1:00pm (EDT) The prevalence of thyroid disease worldwide has served as a catalyst for healthcare providers to study various tools and methods to...
      Speaker: Dr. Tar-Choon Aw
      Sponsored By: Abbott
      16
      NOV 30, 2021 | 7:00 AM
      A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
      A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
      Date: November 30, 2021 Time: 7:00am (PDT), 10:00am (EDT) Wastewater Surveillance programs for SARS-CoV-2 are being implemented by health authorities globally. Many laboratories are currentl...
      Speaker: Subhanjan Mondal , Carlotta Olivero
      Sponsored By: Promega
      8 1
      NOV 18, 2021 | 9:00 AM
      Accelerating AAV capsid purity and genome integrity analysis of adeno-associated viruses (AAV) using multi-capillary gel electrophoresis
      Accelerating AAV capsid purity and genome integrity analysis of...
      Date: November 18, 2021 Time: 9:00am (PDT), 12:00pm (EDT) AAVs are attractive viral vectors for gene therapy due to their lack of pathogenicity, low immunogenicity, broad tropism and persist...
      Speaker: Tingting Li, MS
      Sponsored By: SCIEX
      3
      NOV 18, 2021 | 8:00 AM
      Methods to advance your CAR T & CAR NK cell research
      Methods to advance your CAR T & CAR NK cell research
      Date: November 18, 2021 Time: 8:00am (PDT), 11:00am (EDT) Keep ahead in CAR T and CAR NK cell research. We introduce advanced techniques for generating and characterizing engineered immune c...
      Speaker: Dr. Julia Hengst , Saskia Rƶsch, PhD
      Sponsored By: Miltenyi Biotec
      5
      NOV 17, 2021 | 9:00 AM
      Transform your timelines: Cut development time through multi-capillary CE-SDS and cIEF analysis of mAbs and mAb variants
      Transform your timelines: Cut development time through multi-capillary...
      Date: November 18, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Therapeutic proteins such as monoclonal antibodies (mAbs) and mAb variants have been successfully applied in the treatment of cancer...
      Speaker: Marcia Santos
      Sponsored By: SCIEX
      2
      NOV 17, 2021 | 8:00 AM
      Exosomes: From pure isolation to standardized analysis by flow cytometry
      Exosomes: From pure isolation to standardized analysis by flow...
      Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
      Speaker: Ariadna Pascual Velazquez , Laura Müller , Stefan Wild, PhD
      Sponsored By: Miltenyi Biotec
      9
      NOV 17, 2021 | 6:00 AM
      Aldosterone and Renin Measurements in the Management of Patients with Hypertension
      Aldosterone and Renin Measurements in the Management of Patients...
      Date: November 17, 2021 Time: 6:00am (PDT), 9:00am (EDT) Primary Aldosteronism (PA) is a specifically treatable and potentially curable form of secondary hypertension. However, despite the r...
      Speaker: Paolo Mulatero
      Sponsored By: Diasorin
      9
      NOV 16, 2021 | 10:00 AM
      Towards a mechanistic understanding of motile and primary cilia with CLEM and cryo-electron tomography and expansion microscopy
      Towards a mechanistic understanding of motile and primary cilia...
      Date: November 16, 2021 Time: 10:00am PDT In this talk I will show how the power of modern electron microscopy (EM) techniques, coupled with light microscopy and expansion methods, can open...
      Speaker: Gaia Pigino
      Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
      Sponsored By: Thermo Fisher Scientific
      1
      NOV 15, 2021 | 6:00 AM
      Fully automated RNA library preparation for sequencing respiratory viruses
      Fully automated RNA library preparation for sequencing respiratory...
      Date: November 15, 2021 Time: 6:00am (PDT), 9:00am (EDT) Targeted sequencing of respiratory viruses’ genomes is important to identify novel viral variants. Compared to amplicon sequenc...
      Speaker: Dr. Tomasz Zemojtel , Randy Pares
      Sponsored By: Beckman Coulter Life Sciences
      6
      NOV 10, 2021 | 11:55 PM
      COVID-19 Serology Testing in the Pandemic: Lessons Learned
      COVID-19 Serology Testing in the Pandemic: Lessons Learned
      Lab-on-a-chip platforms enable advanced processing, manipulation, and analysis of biological samples in miniaturized fluidic devices. Despite the numerous advantages, such as lower reagent a...
      Speaker: Raymond Suhandynata, PhD, NRCC (CC)
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
      1
      NOV 10, 2021 | 1:30 PM
      Advancements in UTI Testing: A Multi-omics Approach
      Advancements in UTI Testing: A Multi-omics Approach
      While clinical microbiology laboratories are pivotal in the identification and handling of infectious diseases, the microbiology lab environment is rapidly changing. Conventional testing met...
      Speaker: David Baunoch, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
      Sponsored By: Thermo Fisher Scientific
      3
      NOV 10, 2021 | 1:30 PM
      Keynote Panel Presentation: Successes and Challenges: Developing a 30-second Photonic Detection Diagnostic for the Price of a Latte
      Keynote Panel Presentation: Successes and Challenges: Developing...
      What does it take to develop a novel diagnostic medical device that can increase health equity globally? This keynote panel presentation will discuss a variety of challenges and successes th...
      Speaker: Asma H. Mirza , Tra T. Tran, MSc-GH
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
      2
      NOV 10, 2021 | 12:00 PM
      Confidence in your Calibrators - Introducing the MassTrak Endocrine Steroid Calibrator and Quality Control Sets
      Confidence in your Calibrators - Introducing the MassTrak Endocrine...
      The routine analysis of steroid hormones is critical in understanding the function of metabolic pathways that impact sexual characteristics, inflammation and blood pressure. Liquid Chromatog...
      Speaker: Dominic Foley
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
      Sponsored By: Waters (Clinical Diagnostics & Research)
      2
      NOV 10, 2021 | 10:30 AM
      Operation Moonshot: Rapid Translation of a SARS CoV2 LC-MS/MS Test from Research to Routine Use
      Operation Moonshot: Rapid Translation of a SARS CoV2 LC-MS/MS...
      The Moonshot program was established in the UK by The Department of Health and Social Care to explore novel technologies for the detection of SARS-COV-2. Mass spectrometry was identified as...
      Speaker: Dr. Rachel Carling
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
      Sponsored By: Waters (Clinical Diagnostics & Research)
      1
      NOV 10, 2021 | 9:00 AM
      Keynote Presentation: AI in Times of COVID-19: the COVID-Net Open Source Initiative
      Keynote Presentation: AI in Times of COVID-19: the COVID-Net Open...
      The COVID-19 pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective clinical decisi...
      Speaker: Alexander Wong, Ph.D., P.Eng., SMIEEE
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
      3
      NOV 10, 2021 | 6:00 AM
      Keynote Panel Presentation: Solid Phase Microextraction: New Developments in Bioanalysis and Medical Applications
      Keynote Panel Presentation: Solid Phase Microextraction: New Developments...
      Solid phase microextraction (SPME) is a versatile, non-exhaustive sample preparation tool that has been demonstrated to be well-suited for facile and effective analysis of a broad range of c...
      Speaker: Janusz Pawliszyn, PhD, FCIC, FRSC , Barbara Bojko, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
      3
      NOV 10, 2021 | 6:00 AM
      High-throughput, high resolution purity and heterogeneity characterization of biologics using breakthrough multi-capillary technology
      High-throughput, high resolution purity and heterogeneity characterization...
      Date: November 10, 2021 Time: 6:00am (PST), 9:00am (EST) Over the last 20 years, automated capillary electrophoresis (CE) has become an industry-preferred technique for quantitative purity a...
      Speaker: Fang Wang, PhD
      Sponsored By: SCIEX
      4
      NOV 09, 2021 | 11:00 AM
      Chemical cytoprotection for stress-free use of human stem cells in basic and translational research
      Chemical cytoprotection for stress-free use of human stem cells...
      Date: November 09, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Clinical translation of human pluripotent stem cells (hPSCs) requires advanced strategies that ensure safe and robust long-term gro...
      Speaker: Dr. Ilyas SingeƧ
      Sponsored By: Namocell
      5
      NOV 09, 2021 | 9:00 AM
      Advances in Celiac Disease Testing: From method validation to serological diagnosis
      Advances in Celiac Disease Testing: From method validation to...
      Date: November 9, 2021 Time: 9:00am (PDT), 12:00pm (EDT) CD serology plays an important role in CD screening, diagnosis and monitoring of dietary adherence and ongoing mucosal inflammation....
      Speaker: Lusia Sepiashvili , Jane Dickerson
      Sponsored By: Bio-Rad Laboratories
      9
      NOV 08, 2021 | 8:00 AM
      Learn how to maximize KingFisher instruments to automate DNA, RNA, proteins & cells for all applications
      Learn how to maximize KingFisher instruments to automate DNA,...
      Date: November 8, 2021 Time: 8:00am (PDT), 11:00am (EDT) Explore the adaptability of your KingFisher instrument. Discover all the ways your Thermo Scientific™ KingFisher™ system...
      Speaker: Ketil Pedersen, Ph.D , Emily Zeringer , Suraj Patel, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      9
      NOV 03, 2021 | 12:00 PM
      Treatment of Co-Occurring Methamphetamine and Opioid Use Disorders
      Treatment of Co-Occurring Methamphetamine and Opioid Use Disorders
      Stimulants are the drivers of the fourth wave of the US drug overdose epidemic. Although most national attention and resources have been targeted at combating opioid use due to the surge of...
      Speaker: Mariah M. Kalmin, PhD
      Presented at: Opioid Crisis Virtual Event Series 2021
      0
      NOV 03, 2021 | 6:00 AM
      Engaging in Opioid Use Disorder Stigma Reduction: An Overview
      Engaging in Opioid Use Disorder Stigma Reduction: An Overview
      In recent years substance-related overdoses, many of which involve opioids, have contributed to more deaths than car accidents. Opioid Use Disorder (OUD) is a medical condition that continue...
      Speaker: Ashley Yaugher, PhD
      Presented at: Opioid Crisis Virtual Event Series 2021
      1
    DEC 01, 2021 | 8:00 AM
    Resolving Challenges in Cell Media Culture Presentation
    Resolving Challenges in Cell Media Culture Presentation
    Date: December 01, 2021 Time: 8:00am (PDT), 11:00am (EDT) Discover how taking a holistic approach can help simplify and improve your cell culture media process workflows. In a discussion wit...
    Speaker: Michael De La Cruz, Ph.D.
    Sponsored By: FUJIFILM Irvine Scientific
    9
    NOV 30, 2021 | 11:00 AM
    Clinical value of measurable residual disease assessment in multiple myeloma
    Clinical value of measurable residual disease assessment in multiple...
    Date: November 30, 2021 Time: 11:00am (PDT), 2:00pm (EDT) In the recent years, measurable residual disease (MRD) assessment on multiple myeloma patients has gained increasing relevance. After...
    Speaker: Juan Flores-Montero, MD, PhD
    Sponsored By: Cytognos
    15
    NOV 30, 2021 | 10:00 AM
    The Role of the Laboratory in Managing Thyroid Health
    The Role of the Laboratory in Managing Thyroid Health
    Date: November 30, 2021 Time: 10:00am (PDT), 1:00pm (EDT) The prevalence of thyroid disease worldwide has served as a catalyst for healthcare providers to study various tools and methods to...
    Speaker: Dr. Tar-Choon Aw
    Sponsored By: Abbott
    16
    NOV 30, 2021 | 7:00 AM
    A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
    A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
    Date: November 30, 2021 Time: 7:00am (PDT), 10:00am (EDT) Wastewater Surveillance programs for SARS-CoV-2 are being implemented by health authorities globally. Many laboratories are currentl...
    Speaker: Subhanjan Mondal , Carlotta Olivero
    Sponsored By: Promega
    8 1
    NOV 18, 2021 | 9:00 AM
    Accelerating AAV capsid purity and genome integrity analysis of adeno-associated viruses (AAV) using multi-capillary gel electrophoresis
    Accelerating AAV capsid purity and genome integrity analysis of...
    Date: November 18, 2021 Time: 9:00am (PDT), 12:00pm (EDT) AAVs are attractive viral vectors for gene therapy due to their lack of pathogenicity, low immunogenicity, broad tropism and persist...
    Speaker: Tingting Li, MS
    Sponsored By: SCIEX
    3
     
     
  • NOV 18, 2021 | 8:00 AM
    Methods to advance your CAR T & CAR NK cell research
    Methods to advance your CAR T & CAR NK cell research
    Date: November 18, 2021 Time: 8:00am (PDT), 11:00am (EDT) Keep ahead in CAR T and CAR NK cell research. We introduce advanced techniques for generating and characterizing engineered immune c...
    Speaker: Dr. Julia Hengst , Saskia Rƶsch, PhD
    Sponsored By: Miltenyi Biotec
    5
    NOV 17, 2021 | 9:00 AM
    Transform your timelines: Cut development time through multi-capillary CE-SDS and cIEF analysis of mAbs and mAb variants
    Transform your timelines: Cut development time through multi-capillary...
    Date: November 18, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Therapeutic proteins such as monoclonal antibodies (mAbs) and mAb variants have been successfully applied in the treatment of cancer...
    Speaker: Marcia Santos
    Sponsored By: SCIEX
    2
    NOV 17, 2021 | 8:00 AM
    Exosomes: From pure isolation to standardized analysis by flow cytometry
    Exosomes: From pure isolation to standardized analysis by flow...
    Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
    Speaker: Ariadna Pascual Velazquez , Laura Müller , Stefan Wild, PhD
    Sponsored By: Miltenyi Biotec
    9
    NOV 17, 2021 | 6:00 AM
    Aldosterone and Renin Measurements in the Management of Patients with Hypertension
    Aldosterone and Renin Measurements in the Management of Patients...
    Date: November 17, 2021 Time: 6:00am (PDT), 9:00am (EDT) Primary Aldosteronism (PA) is a specifically treatable and potentially curable form of secondary hypertension. However, despite the r...
    Speaker: Paolo Mulatero
    Sponsored By: Diasorin
    9
    NOV 16, 2021 | 10:00 AM
    Towards a mechanistic understanding of motile and primary cilia with CLEM and cryo-electron tomography and expansion microscopy
    Towards a mechanistic understanding of motile and primary cilia...
    Date: November 16, 2021 Time: 10:00am PDT In this talk I will show how the power of modern electron microscopy (EM) techniques, coupled with light microscopy and expansion methods, can open...
    Speaker: Gaia Pigino
    Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
    Sponsored By: Thermo Fisher Scientific
    1
     
     
  • NOV 15, 2021 | 6:00 AM
    Fully automated RNA library preparation for sequencing respiratory viruses
    Fully automated RNA library preparation for sequencing respiratory...
    Date: November 15, 2021 Time: 6:00am (PDT), 9:00am (EDT) Targeted sequencing of respiratory viruses’ genomes is important to identify novel viral variants. Compared to amplicon sequenc...
    Speaker: Dr. Tomasz Zemojtel , Randy Pares
    Sponsored By: Beckman Coulter Life Sciences
    6
    NOV 10, 2021 | 11:55 PM
    COVID-19 Serology Testing in the Pandemic: Lessons Learned
    COVID-19 Serology Testing in the Pandemic: Lessons Learned
    Lab-on-a-chip platforms enable advanced processing, manipulation, and analysis of biological samples in miniaturized fluidic devices. Despite the numerous advantages, such as lower reagent a...
    Speaker: Raymond Suhandynata, PhD, NRCC (CC)
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
    1
    NOV 10, 2021 | 1:30 PM
    Advancements in UTI Testing: A Multi-omics Approach
    Advancements in UTI Testing: A Multi-omics Approach
    While clinical microbiology laboratories are pivotal in the identification and handling of infectious diseases, the microbiology lab environment is rapidly changing. Conventional testing met...
    Speaker: David Baunoch, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
    Sponsored By: Thermo Fisher Scientific
    3
    NOV 10, 2021 | 1:30 PM
    Keynote Panel Presentation: Successes and Challenges: Developing a 30-second Photonic Detection Diagnostic for the Price of a Latte
    Keynote Panel Presentation: Successes and Challenges: Developing...
    What does it take to develop a novel diagnostic medical device that can increase health equity globally? This keynote panel presentation will discuss a variety of challenges and successes th...
    Speaker: Asma H. Mirza , Tra T. Tran, MSc-GH
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
    2
    NOV 10, 2021 | 12:00 PM
    Confidence in your Calibrators - Introducing the MassTrak Endocrine Steroid Calibrator and Quality Control Sets
    Confidence in your Calibrators - Introducing the MassTrak Endocrine...
    The routine analysis of steroid hormones is critical in understanding the function of metabolic pathways that impact sexual characteristics, inflammation and blood pressure. Liquid Chromatog...
    Speaker: Dominic Foley
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
    Sponsored By: Waters (Clinical Diagnostics & Research)
    2
     
     
  • NOV 10, 2021 | 10:30 AM
    Operation Moonshot: Rapid Translation of a SARS CoV2 LC-MS/MS Test from Research to Routine Use
    Operation Moonshot: Rapid Translation of a SARS CoV2 LC-MS/MS...
    The Moonshot program was established in the UK by The Department of Health and Social Care to explore novel technologies for the detection of SARS-COV-2. Mass spectrometry was identified as...
    Speaker: Dr. Rachel Carling
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
    Sponsored By: Waters (Clinical Diagnostics & Research)
    1
    NOV 10, 2021 | 9:00 AM
    Keynote Presentation: AI in Times of COVID-19: the COVID-Net Open Source Initiative
    Keynote Presentation: AI in Times of COVID-19: the COVID-Net Open...
    The COVID-19 pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective clinical decisi...
    Speaker: Alexander Wong, Ph.D., P.Eng., SMIEEE
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
    3
    NOV 10, 2021 | 6:00 AM
    Keynote Panel Presentation: Solid Phase Microextraction: New Developments in Bioanalysis and Medical Applications
    Keynote Panel Presentation: Solid Phase Microextraction: New Developments...
    Solid phase microextraction (SPME) is a versatile, non-exhaustive sample preparation tool that has been demonstrated to be well-suited for facile and effective analysis of a broad range of c...
    Speaker: Janusz Pawliszyn, PhD, FCIC, FRSC , Barbara Bojko, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
    3
    NOV 10, 2021 | 6:00 AM
    High-throughput, high resolution purity and heterogeneity characterization of biologics using breakthrough multi-capillary technology
    High-throughput, high resolution purity and heterogeneity characterization...
    Date: November 10, 2021 Time: 6:00am (PST), 9:00am (EST) Over the last 20 years, automated capillary electrophoresis (CE) has become an industry-preferred technique for quantitative purity a...
    Speaker: Fang Wang, PhD
    Sponsored By: SCIEX
    4
    NOV 09, 2021 | 11:00 AM
    Chemical cytoprotection for stress-free use of human stem cells in basic and translational research
    Chemical cytoprotection for stress-free use of human stem cells...
    Date: November 09, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Clinical translation of human pluripotent stem cells (hPSCs) requires advanced strategies that ensure safe and robust long-term gro...
    Speaker: Dr. Ilyas SingeƧ
    Sponsored By: Namocell
    5
     
     
  • NOV 09, 2021 | 9:00 AM
    Advances in Celiac Disease Testing: From method validation to serological diagnosis
    Advances in Celiac Disease Testing: From method validation to...
    Date: November 9, 2021 Time: 9:00am (PDT), 12:00pm (EDT) CD serology plays an important role in CD screening, diagnosis and monitoring of dietary adherence and ongoing mucosal inflammation....
    Speaker: Lusia Sepiashvili , Jane Dickerson
    Sponsored By: Bio-Rad Laboratories
    9
    NOV 08, 2021 | 8:00 AM
    Learn how to maximize KingFisher instruments to automate DNA, RNA, proteins & cells for all applications
    Learn how to maximize KingFisher instruments to automate DNA,...
    Date: November 8, 2021 Time: 8:00am (PDT), 11:00am (EDT) Explore the adaptability of your KingFisher instrument. Discover all the ways your Thermo Scientific™ KingFisher™ system...
    Speaker: Ketil Pedersen, Ph.D , Emily Zeringer , Suraj Patel, Ph.D.
    Sponsored By: Thermo Fisher Scientific
    9
    NOV 03, 2021 | 12:00 PM
    Treatment of Co-Occurring Methamphetamine and Opioid Use Disorders
    Treatment of Co-Occurring Methamphetamine and Opioid Use Disorders
    Stimulants are the drivers of the fourth wave of the US drug overdose epidemic. Although most national attention and resources have been targeted at combating opioid use due to the surge of...
    Speaker: Mariah M. Kalmin, PhD
    Presented at: Opioid Crisis Virtual Event Series 2021
    0
    NOV 03, 2021 | 6:00 AM
    Engaging in Opioid Use Disorder Stigma Reduction: An Overview
    Engaging in Opioid Use Disorder Stigma Reduction: An Overview
    In recent years substance-related overdoses, many of which involve opioids, have contributed to more deaths than car accidents. Opioid Use Disorder (OUD) is a medical condition that continue...
    Speaker: Ashley Yaugher, PhD
    Presented at: Opioid Crisis Virtual Event Series 2021
    1
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