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    Dna structure

    Deoxyribonucleic acid (DNA) is made up of two strands winding around each other to generate a "double helix". The backbone of each individual strand consists of sugar and phosphate groups. Each sugar is attached to a base: adenine (A), cytosine (C), guanine (G), or thymine (T).

    Webinars

    • MAR 27, 2024 | 9:00 AM
      PART 1: Utilizing the 6-base genome to investigate the dynamics of enhancer DNA methylation during cellular differentiation
      PART 1: Utilizing the 6-base genome to investigate the dynamics...
      Join Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, to learn more about how the Hodges Lab is utilizing the 6-base genome to investigate the dynamics of enha...
      Speaker: Dr. Emily Hodges
      Sponsored By: biomodal
      11
      JAN 23, 2024 | 11:00 AM
      Maximizing the Potential of 3D Organoid Research with Automated Isolation
      Maximizing the Potential of 3D Organoid Research with Automated...
      The study of 3D organoids has transformed biomedical research, offering a more accurate representation of in vivo conditions. Maximizing the potential of 3D organoid research requires advanc...
      Speaker: Andris Abramenkovs
      Presented at: The Future of Biomedicine: Reproducible Advanced Cell Systems and Translational Insights
      3
      OCT 24, 2023 | 10:00 AM
      An epic advance in epigenomics: Automated CUT&RUN enables chromatin profiling for scaled research & drug discovery applications
      An epic advance in epigenomics: Automated CUT&RUN enables chromatin...
      Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
      Speaker: Andrea Johnstone, Ph.D. , Lori Euler
      Sponsored By: Beckman Coulter Life Sciences
      30
      JUL 26, 2023 | 4:05 PM
      Discovery and engineering of a miniature CRISPR-Cas type V-L system
      Discovery and engineering of a miniature CRISPR-Cas type V-L system
      Employing a metagenomic search, we identified a family of miniature CRISPR-Cas type V-L systems capable of RNA-guided dsDNA target cleavage without a tracrRNA. A bacterial depletion screen r...
      Speaker: Lauren Alfonse
      Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
      6
      MAR 07, 2023 | 9:00 AM
      Enabling High-throughput Biology with New Technologies for Synthetic Construct Sequencing
      Enabling High-throughput Biology with New Technologies for Synthetic...
      Date: March 07, 2023 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CET) The ability to synthesize and sequence vast numbers of DNA constructs is a cornerstone of modern high-throughput biologic...
      Speaker: Joseph C. Mellor, Ph.D. , Henry Chan, Ph.D. , Bryan Jiang
      Sponsored By: seqWell
      15
      FEB 15, 2023 | 7:00 AM
      Scattering Microscopy: Label-Free Imaging Approaches
      Scattering Microscopy: Label-Free Imaging Approaches
      Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
      Speaker: Philipp Kukura , Francesco Reina , Matthew Kose-Dunn , Phil Allen
      Sponsored By: Teledyne Photometrics
      28
      NOV 17, 2022 | 11:00 AM
      EM ICE - Workflows in Every Direction
      EM ICE - Workflows in Every Direction
      Date: November 17, 2022 Time: 11:00am (PST), 2:00pm (EST), 8:00pm (CEST) High pressure freezing offers versatile and deep capability in the study of intricate changes in fine structure or ce...
      Speaker: Seth Villarreal
      Sponsored By: Leica Microsystems
      10
      NOV 17, 2022 | 8:00 AM
      Getting started in Cryo-EM: Virtual Workshop
      Getting started in Cryo-EM: Virtual Workshop
      Date: November 17, 2022 Time: 8:00am PST, 11:00am EST Genome editing is—or will soon be—in the clinic for several diseases and more applications are currently under development....
      Speaker: Natalia de Val , Zuben Brown , Veer Bhatt
      Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
      Sponsored By: Thermo Fisher Scientific
      11
      MAY 24, 2022 | 11:00 AM
      Next-Generation Sequencing (NGS) Assessment of Homologous Recombination Deficiency (HRD): Expanding NGS Data to View Events Associated with Genomic Instability
      Next-Generation Sequencing (NGS) Assessment of Homologous Recombination...
      Date: May 24, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 7:00pm (CEST) NGS tumor profiling has become the mainstay of modern cancer therapy. Several NCCN-guided and FDA-approved therapies are c...
      Speaker: Dr. Christopher Lum, M.D. , Zan Halford, M.S. SMB(ASCP)CM,
      Sponsored By: BioDiscovery, A Bionano Genomics Company
      18
      MAY 19, 2022 | 8:00 AM
      Automated sample preparation for reproducible clinical proteomics
      Automated sample preparation for reproducible clinical proteomics
      Date: May 19, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Mass spectrometry (MS)-based proteomic technologies are increasingly applied in a clinical context for disease classific...
      Speaker: Jeroen Krijgsveld , Nicolas Autret, PhD , Ignasi Forné, PhD
      Sponsored By: Covaris, Inc.
      14
      MAR 09, 2022 | 8:00 AM
      Biosecurity for Genome Engineering: Safety First and the SeqScreen Solution for Functional Predictions
      Biosecurity for Genome Engineering: Safety First and the SeqScreen...
      Date: March 09, 2021 Time: 08:00am (PST), 11:00am (EST), 5:00pm (CEST) Bioengineering technologies hold enormous potential to solve many of our world’s pressing problems. However, they...
      Speaker: Todd Treangen, PhD , Krista Ternus, PhD, PMP , Beth Vitalis, PhD
      Sponsored By: Inscripta
      5
      FEB 09, 2022 | 9:00 AM
      An Approach to Ultrasensitive Detection and Quantification of Copy Number Variations (CNVs) and Mutations
      An Approach to Ultrasensitive Detection and Quantification of...
      Date: February 09, 2021 Time: 09:00am (PST), 12:00pm (EST) In this webinar we introduce quantitative amplicon sequencing (QASeq): a highly-sensitive and robust NGS-based method for the detec...
      Speaker: Nicolas Garreau de Loubresse, Ph.D. , Jinny Zhang, Ph.D.
      Sponsored By: Nuprobe
      20
      OCT 14, 2021 | 7:00 AM
      Heterologous Protein Engineering and characterization of native regulatory elements  in E. coli using Massively Parallel CRISPR Editing
      Heterologous Protein Engineering and characterization of native...
      Date: October 14, 2021 Time: 7:00am (PDT), 10:00am (EDT) Heterologous protein expression in model organisms has many applications, including protein engineering, production of industrial enz...
      Speaker: Tyson Shepherd, PhD
      Sponsored By: Inscripta
      22
      SEP 22, 2021 | 11:00 PM
      Failing Tethers Destabilize Neutrophil Rolling and Form Elongated Neutrophil-Derived Structures (ENDS) in the Blood Circulation
      Failing Tethers Destabilize Neutrophil Rolling and Form Elongated...
      Neutrophils are the most abundant immune cells in human blood and are crucial for host defense against bacterial and fungal infections. Neutrophils are made mainly in the bone marrow from wh...
      Speaker: Alex Marki
      Presented at: Cell Biology Virtual Event Series 2021
      1
      JUL 01, 2021 | 8:00 AM
      Quality control advancements in therapeutic genome editing and biomanufacturing
      Quality control advancements in therapeutic genome editing and...
      Date: July 1, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) What’s driving precision-medicine innovations? New advances in gene and cell therapy manufacturing, along with more...
      Speaker: Imen Mestiri, PhD
      Sponsored By: Genomic Vision
      9
      JUN 30, 2021 | 7:00 AM
      Optical Genome Mapping: Unrivaled Structural Variant Detection for Cancer Research and Precision Medicine
      Optical Genome Mapping: Unrivaled Structural Variant Detection...
      Date: June 30, 2021 Time: 7:00am (PDT), 8:00am (EDT) Join us to discover how Optical genome mapping (OGM) mapping can help you in the characterization of complex samples. OGM is a non-sequen...
      Speaker: Yannick Delpu, PhD , Darren "Ben" Finlay, PhD
      Sponsored By: Bionano
      8
      JUN 29, 2021 | 11:00 AM
      Advancing Cellular Ultrastructure Research with Freeze-Fracture and Freeze-Etching
      Advancing Cellular Ultrastructure Research with Freeze-Fracture...
      Date: June 29, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Freeze-fracture and freeze-etching are useful tools for studying flexible membrane-associated structures such as tight junctions or the...
      Speaker: Evan Krystofiak , Seth Villarreal
      Sponsored By: Leica Microsystems
      9 1
      JUN 24, 2021 | 7:00 AM
      Improved quantitative understanding of oncological replication kinetics  using molecular combing
      Improved quantitative understanding of oncological replication...
      Date: June 24, 2021 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Problem: A comprehensive mechanistic understanding of how genetic alterations impact cancer development and therapeutic i...
      Speaker: Mario Avarello, MSc
      Sponsored By: Genomic Vision
      3
      JUN 10, 2021 | 8:55 AM
      Next Level of Interactome: Methods for Discovering Novel Protein-Nucleic  Acid Interactions from Complex Samples
      Next Level of Interactome: Methods for Discovering Novel Protein-Nucleic...
      Mass spectrometry-based proteomics methods are finding increasing use in structural biology research. Beyond simple interaction networks, information about stable protein-protein, protein-li...
      Speaker: Henning Urlaub
      Presented at: Shaping the Future of LC-MS in Life Science Together
      1
      JUN 10, 2021 | 7:00 AM
      Simplify complex genetic diseases by quantifying structural and copy number variants
      Simplify complex genetic diseases by quantifying structural and...
      Date: June 10, 2021 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Discover how to categorize small-to-large genetic modifications using molecular combing. Our Proprietary Genome Morse Cod...
      Speaker: Mario Avarello, MSc
      Sponsored By: Genomic Vision
      8 1
      JUN 03, 2021 | 8:00 AM
      How molecular combing technology is transforming genomic research through visualizing DNA at the single-molecule level
      How molecular combing technology is transforming genomic research...
      Date: June 3, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Molecular combing provides unbiased quantification and characterization of DNA structure and dynamics by imaging single DN...
      Speaker: Mark Lynch
      Sponsored By: Genomic Vision
      11 1
      MAY 25, 2021 | 8:00 AM
      Complete Workflow Solution from Gene-to-Protein
      Complete Workflow Solution from Gene-to-Protein
      Date: May 25, 2021 Time: 8:00am (PDT) Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, bu...
      Speaker: Stephan Fath, PhD
      Sponsored By: Thermo Fisher Scientific
      16 1
      MAY 11, 2021 | 10:00 AM
      Secure Your Next Great Discovery
      Secure Your Next Great Discovery
      Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
      Speaker: Paulina Kocjan , Kate Meola , Zareh Zurabyan
      Presented at: Eppendorf Planet of Knowledge - A New Dimension
      Sponsored By: Eppendorf
      8
      MAY 05, 2021 | 12:00 AM
      Leveraging Bioinformatic Resources to Better Tackle Challenging Biological Substrates and DNA Profiles
      Leveraging Bioinformatic Resources to Better Tackle Challenging...
      Short tandem repeats (STRs) are gold-standard genetic loci used for source attribution of evidentiary material in legal matters. Their power lies in their high heterozygosity and large allel...
      Speaker: Frank Wendt, PhD
      Presented at: Forensic Sciences Virtual Event Series 2021
      1
    MAR 27, 2024 | 9:00 AM
    PART 1: Utilizing the 6-base genome to investigate the dynamics of enhancer DNA methylation during cellular differentiation
    PART 1: Utilizing the 6-base genome to investigate the dynamics...
    Join Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, to learn more about how the Hodges Lab is utilizing the 6-base genome to investigate the dynamics of enha...
    Speaker: Dr. Emily Hodges
    Sponsored By: biomodal
    11
    JAN 23, 2024 | 11:00 AM
    Maximizing the Potential of 3D Organoid Research with Automated Isolation
    Maximizing the Potential of 3D Organoid Research with Automated...
    The study of 3D organoids has transformed biomedical research, offering a more accurate representation of in vivo conditions. Maximizing the potential of 3D organoid research requires advanc...
    Speaker: Andris Abramenkovs
    Presented at: The Future of Biomedicine: Reproducible Advanced Cell Systems and Translational Insights
    3
    OCT 24, 2023 | 10:00 AM
    An epic advance in epigenomics: Automated CUT&RUN enables chromatin profiling for scaled research & drug discovery applications
    An epic advance in epigenomics: Automated CUT&RUN enables chromatin...
    Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
    Speaker: Andrea Johnstone, Ph.D. , Lori Euler
    Sponsored By: Beckman Coulter Life Sciences
    30
    JUL 26, 2023 | 4:05 PM
    Discovery and engineering of a miniature CRISPR-Cas type V-L system
    Discovery and engineering of a miniature CRISPR-Cas type V-L system
    Employing a metagenomic search, we identified a family of miniature CRISPR-Cas type V-L systems capable of RNA-guided dsDNA target cleavage without a tracrRNA. A bacterial depletion screen r...
    Speaker: Lauren Alfonse
    Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
    6
    MAR 07, 2023 | 9:00 AM
    Enabling High-throughput Biology with New Technologies for Synthetic Construct Sequencing
    Enabling High-throughput Biology with New Technologies for Synthetic...
    Date: March 07, 2023 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CET) The ability to synthesize and sequence vast numbers of DNA constructs is a cornerstone of modern high-throughput biologic...
    Speaker: Joseph C. Mellor, Ph.D. , Henry Chan, Ph.D. , Bryan Jiang
    Sponsored By: seqWell
    15
     
     
  • FEB 15, 2023 | 7:00 AM
    Scattering Microscopy: Label-Free Imaging Approaches
    Scattering Microscopy: Label-Free Imaging Approaches
    Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
    Speaker: Philipp Kukura , Francesco Reina , Matthew Kose-Dunn , Phil Allen
    Sponsored By: Teledyne Photometrics
    28
    NOV 17, 2022 | 11:00 AM
    EM ICE - Workflows in Every Direction
    EM ICE - Workflows in Every Direction
    Date: November 17, 2022 Time: 11:00am (PST), 2:00pm (EST), 8:00pm (CEST) High pressure freezing offers versatile and deep capability in the study of intricate changes in fine structure or ce...
    Speaker: Seth Villarreal
    Sponsored By: Leica Microsystems
    10
    NOV 17, 2022 | 8:00 AM
    Getting started in Cryo-EM: Virtual Workshop
    Getting started in Cryo-EM: Virtual Workshop
    Date: November 17, 2022 Time: 8:00am PST, 11:00am EST Genome editing is—or will soon be—in the clinic for several diseases and more applications are currently under development....
    Speaker: Natalia de Val , Zuben Brown , Veer Bhatt
    Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
    Sponsored By: Thermo Fisher Scientific
    11
    MAY 24, 2022 | 11:00 AM
    Next-Generation Sequencing (NGS) Assessment of Homologous Recombination Deficiency (HRD): Expanding NGS Data to View Events Associated with Genomic Instability
    Next-Generation Sequencing (NGS) Assessment of Homologous Recombination...
    Date: May 24, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 7:00pm (CEST) NGS tumor profiling has become the mainstay of modern cancer therapy. Several NCCN-guided and FDA-approved therapies are c...
    Speaker: Dr. Christopher Lum, M.D. , Zan Halford, M.S. SMB(ASCP)CM,
    Sponsored By: BioDiscovery, A Bionano Genomics Company
    18
    MAY 19, 2022 | 8:00 AM
    Automated sample preparation for reproducible clinical proteomics
    Automated sample preparation for reproducible clinical proteomics
    Date: May 19, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Mass spectrometry (MS)-based proteomic technologies are increasingly applied in a clinical context for disease classific...
    Speaker: Jeroen Krijgsveld , Nicolas Autret, PhD , Ignasi Forné, PhD
    Sponsored By: Covaris, Inc.
    14
     
     
  • MAR 09, 2022 | 8:00 AM
    Biosecurity for Genome Engineering: Safety First and the SeqScreen Solution for Functional Predictions
    Biosecurity for Genome Engineering: Safety First and the SeqScreen...
    Date: March 09, 2021 Time: 08:00am (PST), 11:00am (EST), 5:00pm (CEST) Bioengineering technologies hold enormous potential to solve many of our world’s pressing problems. However, they...
    Speaker: Todd Treangen, PhD , Krista Ternus, PhD, PMP , Beth Vitalis, PhD
    Sponsored By: Inscripta
    5
    FEB 09, 2022 | 9:00 AM
    An Approach to Ultrasensitive Detection and Quantification of Copy Number Variations (CNVs) and Mutations
    An Approach to Ultrasensitive Detection and Quantification of...
    Date: February 09, 2021 Time: 09:00am (PST), 12:00pm (EST) In this webinar we introduce quantitative amplicon sequencing (QASeq): a highly-sensitive and robust NGS-based method for the detec...
    Speaker: Nicolas Garreau de Loubresse, Ph.D. , Jinny Zhang, Ph.D.
    Sponsored By: Nuprobe
    20
    OCT 14, 2021 | 7:00 AM
    Heterologous Protein Engineering and characterization of native regulatory elements  in E. coli using Massively Parallel CRISPR Editing
    Heterologous Protein Engineering and characterization of native...
    Date: October 14, 2021 Time: 7:00am (PDT), 10:00am (EDT) Heterologous protein expression in model organisms has many applications, including protein engineering, production of industrial enz...
    Speaker: Tyson Shepherd, PhD
    Sponsored By: Inscripta
    22
    SEP 22, 2021 | 11:00 PM
    Failing Tethers Destabilize Neutrophil Rolling and Form Elongated Neutrophil-Derived Structures (ENDS) in the Blood Circulation
    Failing Tethers Destabilize Neutrophil Rolling and Form Elongated...
    Neutrophils are the most abundant immune cells in human blood and are crucial for host defense against bacterial and fungal infections. Neutrophils are made mainly in the bone marrow from wh...
    Speaker: Alex Marki
    Presented at: Cell Biology Virtual Event Series 2021
    1
    JUL 01, 2021 | 8:00 AM
    Quality control advancements in therapeutic genome editing and biomanufacturing
    Quality control advancements in therapeutic genome editing and...
    Date: July 1, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) What’s driving precision-medicine innovations? New advances in gene and cell therapy manufacturing, along with more...
    Speaker: Imen Mestiri, PhD
    Sponsored By: Genomic Vision
    9
     
     
  • JUN 30, 2021 | 7:00 AM
    Optical Genome Mapping: Unrivaled Structural Variant Detection for Cancer Research and Precision Medicine
    Optical Genome Mapping: Unrivaled Structural Variant Detection...
    Date: June 30, 2021 Time: 7:00am (PDT), 8:00am (EDT) Join us to discover how Optical genome mapping (OGM) mapping can help you in the characterization of complex samples. OGM is a non-sequen...
    Speaker: Yannick Delpu, PhD , Darren "Ben" Finlay, PhD
    Sponsored By: Bionano
    8
    JUN 29, 2021 | 11:00 AM
    Advancing Cellular Ultrastructure Research with Freeze-Fracture and Freeze-Etching
    Advancing Cellular Ultrastructure Research with Freeze-Fracture...
    Date: June 29, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Freeze-fracture and freeze-etching are useful tools for studying flexible membrane-associated structures such as tight junctions or the...
    Speaker: Evan Krystofiak , Seth Villarreal
    Sponsored By: Leica Microsystems
    9 1
    JUN 24, 2021 | 7:00 AM
    Improved quantitative understanding of oncological replication kinetics  using molecular combing
    Improved quantitative understanding of oncological replication...
    Date: June 24, 2021 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Problem: A comprehensive mechanistic understanding of how genetic alterations impact cancer development and therapeutic i...
    Speaker: Mario Avarello, MSc
    Sponsored By: Genomic Vision
    3
    JUN 10, 2021 | 8:55 AM
    Next Level of Interactome: Methods for Discovering Novel Protein-Nucleic  Acid Interactions from Complex Samples
    Next Level of Interactome: Methods for Discovering Novel Protein-Nucleic...
    Mass spectrometry-based proteomics methods are finding increasing use in structural biology research. Beyond simple interaction networks, information about stable protein-protein, protein-li...
    Speaker: Henning Urlaub
    Presented at: Shaping the Future of LC-MS in Life Science Together
    1
    JUN 10, 2021 | 7:00 AM
    Simplify complex genetic diseases by quantifying structural and copy number variants
    Simplify complex genetic diseases by quantifying structural and...
    Date: June 10, 2021 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Discover how to categorize small-to-large genetic modifications using molecular combing. Our Proprietary Genome Morse Cod...
    Speaker: Mario Avarello, MSc
    Sponsored By: Genomic Vision
    8 1
     
     
  • JUN 03, 2021 | 8:00 AM
    How molecular combing technology is transforming genomic research through visualizing DNA at the single-molecule level
    How molecular combing technology is transforming genomic research...
    Date: June 3, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Molecular combing provides unbiased quantification and characterization of DNA structure and dynamics by imaging single DN...
    Speaker: Mark Lynch
    Sponsored By: Genomic Vision
    11 1
    MAY 25, 2021 | 8:00 AM
    Complete Workflow Solution from Gene-to-Protein
    Complete Workflow Solution from Gene-to-Protein
    Date: May 25, 2021 Time: 8:00am (PDT) Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, bu...
    Speaker: Stephan Fath, PhD
    Sponsored By: Thermo Fisher Scientific
    16 1
    MAY 11, 2021 | 10:00 AM
    Secure Your Next Great Discovery
    Secure Your Next Great Discovery
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    Speaker: Paulina Kocjan , Kate Meola , Zareh Zurabyan
    Presented at: Eppendorf Planet of Knowledge - A New Dimension
    Sponsored By: Eppendorf
    8
    MAY 05, 2021 | 12:00 AM
    Leveraging Bioinformatic Resources to Better Tackle Challenging Biological Substrates and DNA Profiles
    Leveraging Bioinformatic Resources to Better Tackle Challenging...
    Short tandem repeats (STRs) are gold-standard genetic loci used for source attribution of evidentiary material in legal matters. Their power lies in their high heterozygosity and large allel...
    Speaker: Frank Wendt, PhD
    Presented at: Forensic Sciences Virtual Event Series 2021
    1
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