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    Human development

    Human development describes the stages of human life. Human development consists of 5 stages. Infancy (up to one year), toddler (age 1 - 5), childhood (age 3 - 11), adolescence (age 12 - 18), and adulthood. The study of human development aims to understand how people grow, develop, and change throughout their life.

    Webinars

    • APR 27, 2021 | 7:00 AM
      High Resolution Imaging of Zebrafish at Nano and Millimeter Scale
      High Resolution Imaging of Zebrafish at Nano and Millimeter Scale
      Date: April 27, 2021 Time: 7:00am (PDT), 11:00am (EDT) Visualization is an important step to address complex biological questions in vivo. The imaging process can widen the perspective of an...
      Speaker: Julien Resseguier , Claudia Florindo, PhD
      Sponsored By: Andor
      8
      APR 22, 2021 | 10:30 AM
      Extraction-free sensitive detection of viral RNA using direct RT-PCR chemistry
      Extraction-free sensitive detection of viral RNA using direct...
      Nucleic acid amplification tests (NAAT) are a reliable, sensitive, and accurate diagnostic approach used in viral detection. The approach involves the isolation of nucleic acids from a sampl...
      Speaker: Donald Green
      Presented at: Genetics Week Virtual Event Series 2021
      Sponsored By: Cytiva
      4 1
      APR 22, 2021 | 6:00 AM
      Panel Presentation: Powering the precision in "precision medicine" - The role of curated data, databases and knowledge: Does a gold standard exist?
      Panel Presentation: Powering the precision in "precision medicine"...
      As NGS panels grow, test interpretation becomes more complex and time-consuming / With the explosion of NGS data, the need for consolidated databases with reliable and transparent curation a...
      Speaker: Dominic John , Simon Forbes, PhD , Shawn Bauer , Lisa Barrow-Laing
      Presented at: Genetics Week Virtual Event Series 2021
      Sponsored By: QIAGEN
      2
      APR 22, 2021 | 10:00 AM
      Role of Chromosomal Microarray in the Era of Genome Sequencing
      Role of Chromosomal Microarray in the Era of Genome Sequencing
      Date: April 22, 2021 Time: 10:00am (CEST), 4:00pm (CST) Advancements in technologies have revolutionized the genetic landscape. Chromosomal microarray analysis (CMA) becomes a proven method...
      Speaker: Richard Choy, BSc (Brad.); MSc(Med) (Birm.); PhD (CUHK)Professor
      Sponsored By: Agilent
      5
      APR 22, 2021 | 12:00 AM
      Laboratory Implementation of Clinical Genomics in Children
      Laboratory Implementation of Clinical Genomics in Children
      Laboratory implementation of clinical genomics in children requires customization of analytical tools tailored to profile the divergent mutational landscape in childhood tumors. The relative...
      Speaker: Angshumoy Roy, MD, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      2
      APR 22, 2021 | 12:00 AM
      Using AI and Predictive Algorithms to Help Advanced Cancer Patients Identify the Best Treatment Options
      Using AI and Predictive Algorithms to Help Advanced Cancer Patients...
      Advanced cancer patients, individuals that have a <50% chance of 5 year-survival and have exhausted standard of care options, are often seeking for innovative therapies. These drugs may b...
      Speaker: Kenny Wong, MS CGC
      Presented at: Genetics Week Virtual Event Series 2021
      2
      APR 21, 2021 | 10:30 AM
      Panel Presentation: Driving lab efficiency with PCR power
      Panel Presentation: Driving lab efficiency with PCR power
      Detection and/or amplification of target DNA sequences by polymerase chain reaction (PCR) is a prevalent method in molecular biology. PCR has a broad range of applications, including use in...
      Speaker: Kyle Hondorp , Marija Navickaitė
      Presented at: Genetics Week Virtual Event Series 2021
      Sponsored By: Thermo Fisher Scientific
      3
      APR 21, 2021 | 5:00 PM
      Immunology Researchers share their Spatial Discoveries in SARS-CoV-2 host response and in multiple sclerosis
      Immunology Researchers share their Spatial Discoveries in SARS-CoV-2...
      Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
      Speaker: Doug Brown, PhD , Susanne Krasemann, MD, PhD , Michelle Naughton, PhD
      Sponsored By: NanoString Technologies, Illumina
      5
      APR 21, 2021 | 7:30 AM
      Panel Presentation: Next-Generation Sequencing in the Global Response to the COVID-19 Pandemic
      Panel Presentation: Next-Generation Sequencing in the Global Response...
      The SARS-CoV-2 pandemic is challenging our health care systems and has profoundly impacted our society. Due to the poor global public health response, SARS-CoV-2 has developed many variants....
      Speaker: Eric Allen, MBA, M. Eng. Bioengineering , Michael Oberholzer, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      2
      APR 21, 2021 | 6:00 AM
      Keynote Presentation: High-throughput Diagnostics and Sequencing at the Pandemic Response Lab NYC
      Keynote Presentation: High-throughput Diagnostics and Sequencing...
      Controlling the spread of the 2019 novel coronavirus SARS-CoV-2 and ensuring a return to 'normal' activities in a post-COVID world requires two complementary efforts: 1) Widespread a...
      Speaker: Jon M. Laurent, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      2
      APR 21, 2021 | 12:00 AM
      A Saliva-Based RT-PCR SARS-CoV-2 Detection Assay: Development and Deployment
      A Saliva-Based RT-PCR SARS-CoV-2 Detection Assay: Development...
      A One-Step RT-qPCR assay based on the CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel has been developed which can effectively detect SARS-CoV-2 particles from saliv...
      Speaker: Suzie Alarcon, CGMBS, MB(ASCP)ᶜᴹ
      Presented at: Genetics Week Virtual Event Series 2021
      3
      APR 21, 2021 | 12:00 AM
      Liquid Biopsy-based Detection of Early Stage Gynecological Cancers
      Liquid Biopsy-based Detection of Early Stage Gynecological Cancers
      According to the American Cancer Society, in there were an estimated 110,070 new cases diagnosed and approximately 32,120 deaths from gynecologic cancers in the U.S. in 2018. Of the five mos...
      Speaker: Lesley E. Northrop, PhD, FACMG
      Presented at: Genetics Week Virtual Event Series 2021
      2
      APR 21, 2021 | 12:00 AM
      Hybrid Capture SARS-CoV-2 NGS Assay and COVID-Dx: a robust end to end solution for viral detection and surveillance of genetic variants
      Hybrid Capture SARS-CoV-2 NGS Assay and COVID-Dx: a robust end...
      As the SARS-CoV-2 continues to spread and evolve and vaccination efforts are under way, countries around the world are confronting new public health challenges due to the emergence and rapid...
      Speaker: Mara Couto-Rodriguez
      Presented at: Genetics Week Virtual Event Series 2021
      1
      APR 20, 2021 | 4:30 PM
      C.E. CREDITS
      High-throughput clinical and environmental viral extraction and sequencing
      High-throughput clinical and environmental viral extraction and...
      COVID-19 is a severe disease that has caused >1 million deaths in under one year. As this disease is novel, the molecular and cellular underpinnings of the progressive tissue injury are p...
      Speaker: Christopher Mason, Ph.D
      Presented at: Genetics Week Virtual Event Series 2021
      Sponsored By: Tecan
      2
      APR 20, 2021 | 3:00 PM
      Panel Presentation: Accelerating precision oncology with matched FFPE and plasma biospecimens characterized using Discovery's SpecimenSeq™ NGS Service and QIAGEN's QIAseq Multimodal Panels
      Panel Presentation: Accelerating precision oncology with matched...
      Bridging a deep understanding of molecular profiles with clinical information is critical to developing innovative precision medicine tools in oncology. Discovery’s recently launched S...
      Speaker: Nathan Henson, MS , Donald Skifter, PhD, MBA
      Presented at: Genetics Week Virtual Event Series 2021
      Sponsored By: QIAGEN
      2
      APR 20, 2021 | 10:00 AM
      Use of a New 3D Pluripotent Stem Cell Suspension Culture Medium for Rapid Scale-Up and Downstream Differentiation of Pluripotent Stem Cells
      Use of a New 3D Pluripotent Stem Cell Suspension Culture Medium...
      Date: April 20, 2021 Time: 10:00am (PST) In order to generate sufficient numbers of pluripotent stem cells (PSCs) for downstream applications, three-dimensional (3D) suspension cultures offe...
      Speaker: Michael Akenhead , Michael Derr
      Sponsored By: Thermo Fisher Scientific
      5
      APR 20, 2021 | 5:00 PM
      Researchers share their Spatial Discoveries in Cancer Research
      Researchers share their Spatial Discoveries in Cancer Research
      Date: April 20, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers on Oncology - Professor Joan Seoane Prof. Joan Seoane, Group Leader and Director of the Translational Re...
      Speaker: Noel De Miranda , Vasilis Stavrinides, MD
      Sponsored By: NanoString Technologies, Illumina
      4
      APR 20, 2021 | 7:30 AM
      C.E. CREDITS
      Keynote Presentation: A structural variation map of 499 Han Chinese individuals using long-read sequencing data
      Keynote Presentation: A structural variation map of 499 Han Chinese...
      Structural variants (SVs) are essential in human evolution and genetic disease but remain understudied. This is especially the case for non-Caucasian ethnicities. We report, for the first ti...
      Speaker: Fritz Sedlazeck, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      1
      APR 20, 2021 | 12:00 AM
      Studying Promoter and Isoform Diversity with Long-Read Transcriptome Sequencing
      Studying Promoter and Isoform Diversity with Long-Read Transcriptome...
      Learning Objectives: 1. Learn about alternative promoters and their role in cancer 2. Learn how long read RNA-Seq helps to study the transcriptome...
      Speaker: Jonathan Göke
      Presented at: Genetics Week Virtual Event Series 2021
      1
      APR 20, 2021 | 12:00 AM
      C.E. CREDITS
      Developing disease insights with genotype-specific regulatory networks
      Developing disease insights with genotype-specific regulatory...
      The recent explosion in the sample sizes and diversity of omics assays has created exciting new opportunities for biomedical scientists. However, connecting these omics data types in an inte...
      Speaker: John Platig, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      2
      APR 20, 2021 | 12:00 AM
      Illuminating Biology with Spatially Resolved, Single-cell Transcriptomics
      Illuminating Biology with Spatially Resolved, Single-cell Transcriptomics
      Biological systems are comprised of numerous cell types, intricately organized to form functional tissues and organs. Cell atlas initiatives with single-cell RNA sequencing have begun to cha...
      Speaker: Jiang He
      Presented at: Genetics Week Virtual Event Series 2021
      1
      APR 20, 2021 | 12:00 AM
      Towards a Comprehensive Variation Benchmark for Medically-Relevant Autosomal Genes
      Towards a Comprehensive Variation Benchmark for Medically-Relevant...
      The Genome in a Bottle Consortium has published benchmarks for variant calling, but some challenging medically-relevant genes have been partially or fully excluded due to mapping challenges,...
      Speaker: Justin Wagner, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      1
      APR 20, 2021 | 12:00 AM
      Epigenetic Aging Studies in Mammals
      Epigenetic Aging Studies in Mammals
      In mammals, DNA methylation is an epigenetic mark that regulates gene expression by serving as a maintainable mark whose absence marks promoters and enhancers. Recent epidemiological studies...
      Speaker: Steve Horvath
      Presented at: Genetics Week Virtual Event Series 2021
      6
      APR 15, 2021 | 8:00 AM
      Human Pluripotent Stem Cells as a Model for Neurodevelopmental Toxicity
      Human Pluripotent Stem Cells as a Model for Neurodevelopmental...
      Date: April 15, 2021 Time: 8:00am PST Stem cell’s unique properties confer them a multitude of potential applications in the fields of cellular therapy, disease modelling and drug scre...
      Speaker: Cláudia Miranda
      Sponsored By: Thermo Fisher Scientific/Gibco
      4
    APR 27, 2021 | 7:00 AM
    High Resolution Imaging of Zebrafish at Nano and Millimeter Scale
    High Resolution Imaging of Zebrafish at Nano and Millimeter Scale
    Date: April 27, 2021 Time: 7:00am (PDT), 11:00am (EDT) Visualization is an important step to address complex biological questions in vivo. The imaging process can widen the perspective of an...
    Speaker: Julien Resseguier , Claudia Florindo, PhD
    Sponsored By: Andor
    8
    APR 22, 2021 | 10:30 AM
    Extraction-free sensitive detection of viral RNA using direct RT-PCR chemistry
    Extraction-free sensitive detection of viral RNA using direct...
    Nucleic acid amplification tests (NAAT) are a reliable, sensitive, and accurate diagnostic approach used in viral detection. The approach involves the isolation of nucleic acids from a sampl...
    Speaker: Donald Green
    Presented at: Genetics Week Virtual Event Series 2021
    Sponsored By: Cytiva
    4 1
    APR 22, 2021 | 6:00 AM
    Panel Presentation: Powering the precision in "precision medicine" - The role of curated data, databases and knowledge: Does a gold standard exist?
    Panel Presentation: Powering the precision in "precision medicine"...
    As NGS panels grow, test interpretation becomes more complex and time-consuming / With the explosion of NGS data, the need for consolidated databases with reliable and transparent curation a...
    Speaker: Dominic John , Simon Forbes, PhD , Shawn Bauer , Lisa Barrow-Laing
    Presented at: Genetics Week Virtual Event Series 2021
    Sponsored By: QIAGEN
    2
    APR 22, 2021 | 10:00 AM
    Role of Chromosomal Microarray in the Era of Genome Sequencing
    Role of Chromosomal Microarray in the Era of Genome Sequencing
    Date: April 22, 2021 Time: 10:00am (CEST), 4:00pm (CST) Advancements in technologies have revolutionized the genetic landscape. Chromosomal microarray analysis (CMA) becomes a proven method...
    Speaker: Richard Choy, BSc (Brad.); MSc(Med) (Birm.); PhD (CUHK)Professor
    Sponsored By: Agilent
    5
    APR 22, 2021 | 12:00 AM
    Laboratory Implementation of Clinical Genomics in Children
    Laboratory Implementation of Clinical Genomics in Children
    Laboratory implementation of clinical genomics in children requires customization of analytical tools tailored to profile the divergent mutational landscape in childhood tumors. The relative...
    Speaker: Angshumoy Roy, MD, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    2
     
     
  • APR 22, 2021 | 12:00 AM
    Using AI and Predictive Algorithms to Help Advanced Cancer Patients Identify the Best Treatment Options
    Using AI and Predictive Algorithms to Help Advanced Cancer Patients...
    Advanced cancer patients, individuals that have a <50% chance of 5 year-survival and have exhausted standard of care options, are often seeking for innovative therapies. These drugs may b...
    Speaker: Kenny Wong, MS CGC
    Presented at: Genetics Week Virtual Event Series 2021
    2
    APR 21, 2021 | 10:30 AM
    Panel Presentation: Driving lab efficiency with PCR power
    Panel Presentation: Driving lab efficiency with PCR power
    Detection and/or amplification of target DNA sequences by polymerase chain reaction (PCR) is a prevalent method in molecular biology. PCR has a broad range of applications, including use in...
    Speaker: Kyle Hondorp , Marija Navickaitė
    Presented at: Genetics Week Virtual Event Series 2021
    Sponsored By: Thermo Fisher Scientific
    3
    APR 21, 2021 | 5:00 PM
    Immunology Researchers share their Spatial Discoveries in SARS-CoV-2 host response and in multiple sclerosis
    Immunology Researchers share their Spatial Discoveries in SARS-CoV-2...
    Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
    Speaker: Doug Brown, PhD , Susanne Krasemann, MD, PhD , Michelle Naughton, PhD
    Sponsored By: NanoString Technologies, Illumina
    5
    APR 21, 2021 | 7:30 AM
    Panel Presentation: Next-Generation Sequencing in the Global Response to the COVID-19 Pandemic
    Panel Presentation: Next-Generation Sequencing in the Global Response...
    The SARS-CoV-2 pandemic is challenging our health care systems and has profoundly impacted our society. Due to the poor global public health response, SARS-CoV-2 has developed many variants....
    Speaker: Eric Allen, MBA, M. Eng. Bioengineering , Michael Oberholzer, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    2
    APR 21, 2021 | 6:00 AM
    Keynote Presentation: High-throughput Diagnostics and Sequencing at the Pandemic Response Lab NYC
    Keynote Presentation: High-throughput Diagnostics and Sequencing...
    Controlling the spread of the 2019 novel coronavirus SARS-CoV-2 and ensuring a return to 'normal' activities in a post-COVID world requires two complementary efforts: 1) Widespread a...
    Speaker: Jon M. Laurent, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    2
     
     
  • APR 21, 2021 | 12:00 AM
    A Saliva-Based RT-PCR SARS-CoV-2 Detection Assay: Development and Deployment
    A Saliva-Based RT-PCR SARS-CoV-2 Detection Assay: Development...
    A One-Step RT-qPCR assay based on the CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel has been developed which can effectively detect SARS-CoV-2 particles from saliv...
    Speaker: Suzie Alarcon, CGMBS, MB(ASCP)ᶜᴹ
    Presented at: Genetics Week Virtual Event Series 2021
    3
    APR 21, 2021 | 12:00 AM
    Liquid Biopsy-based Detection of Early Stage Gynecological Cancers
    Liquid Biopsy-based Detection of Early Stage Gynecological Cancers
    According to the American Cancer Society, in there were an estimated 110,070 new cases diagnosed and approximately 32,120 deaths from gynecologic cancers in the U.S. in 2018. Of the five mos...
    Speaker: Lesley E. Northrop, PhD, FACMG
    Presented at: Genetics Week Virtual Event Series 2021
    2
    APR 21, 2021 | 12:00 AM
    Hybrid Capture SARS-CoV-2 NGS Assay and COVID-Dx: a robust end to end solution for viral detection and surveillance of genetic variants
    Hybrid Capture SARS-CoV-2 NGS Assay and COVID-Dx: a robust end...
    As the SARS-CoV-2 continues to spread and evolve and vaccination efforts are under way, countries around the world are confronting new public health challenges due to the emergence and rapid...
    Speaker: Mara Couto-Rodriguez
    Presented at: Genetics Week Virtual Event Series 2021
    1
    APR 20, 2021 | 4:30 PM
    C.E. CREDITS
    High-throughput clinical and environmental viral extraction and sequencing
    High-throughput clinical and environmental viral extraction and...
    COVID-19 is a severe disease that has caused >1 million deaths in under one year. As this disease is novel, the molecular and cellular underpinnings of the progressive tissue injury are p...
    Speaker: Christopher Mason, Ph.D
    Presented at: Genetics Week Virtual Event Series 2021
    Sponsored By: Tecan
    2
    APR 20, 2021 | 3:00 PM
    Panel Presentation: Accelerating precision oncology with matched FFPE and plasma biospecimens characterized using Discovery's SpecimenSeq™ NGS Service and QIAGEN's QIAseq Multimodal Panels
    Panel Presentation: Accelerating precision oncology with matched...
    Bridging a deep understanding of molecular profiles with clinical information is critical to developing innovative precision medicine tools in oncology. Discovery’s recently launched S...
    Speaker: Nathan Henson, MS , Donald Skifter, PhD, MBA
    Presented at: Genetics Week Virtual Event Series 2021
    Sponsored By: QIAGEN
    2
     
     
  • APR 20, 2021 | 10:00 AM
    Use of a New 3D Pluripotent Stem Cell Suspension Culture Medium for Rapid Scale-Up and Downstream Differentiation of Pluripotent Stem Cells
    Use of a New 3D Pluripotent Stem Cell Suspension Culture Medium...
    Date: April 20, 2021 Time: 10:00am (PST) In order to generate sufficient numbers of pluripotent stem cells (PSCs) for downstream applications, three-dimensional (3D) suspension cultures offe...
    Speaker: Michael Akenhead , Michael Derr
    Sponsored By: Thermo Fisher Scientific
    5
    APR 20, 2021 | 5:00 PM
    Researchers share their Spatial Discoveries in Cancer Research
    Researchers share their Spatial Discoveries in Cancer Research
    Date: April 20, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers on Oncology - Professor Joan Seoane Prof. Joan Seoane, Group Leader and Director of the Translational Re...
    Speaker: Noel De Miranda , Vasilis Stavrinides, MD
    Sponsored By: NanoString Technologies, Illumina
    4
    APR 20, 2021 | 7:30 AM
    C.E. CREDITS
    Keynote Presentation: A structural variation map of 499 Han Chinese individuals using long-read sequencing data
    Keynote Presentation: A structural variation map of 499 Han Chinese...
    Structural variants (SVs) are essential in human evolution and genetic disease but remain understudied. This is especially the case for non-Caucasian ethnicities. We report, for the first ti...
    Speaker: Fritz Sedlazeck, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    1
    APR 20, 2021 | 12:00 AM
    Studying Promoter and Isoform Diversity with Long-Read Transcriptome Sequencing
    Studying Promoter and Isoform Diversity with Long-Read Transcriptome...
    Learning Objectives: 1. Learn about alternative promoters and their role in cancer 2. Learn how long read RNA-Seq helps to study the transcriptome...
    Speaker: Jonathan Göke
    Presented at: Genetics Week Virtual Event Series 2021
    1
    APR 20, 2021 | 12:00 AM
    C.E. CREDITS
    Developing disease insights with genotype-specific regulatory networks
    Developing disease insights with genotype-specific regulatory...
    The recent explosion in the sample sizes and diversity of omics assays has created exciting new opportunities for biomedical scientists. However, connecting these omics data types in an inte...
    Speaker: John Platig, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    2
     
     
  • APR 20, 2021 | 12:00 AM
    Illuminating Biology with Spatially Resolved, Single-cell Transcriptomics
    Illuminating Biology with Spatially Resolved, Single-cell Transcriptomics
    Biological systems are comprised of numerous cell types, intricately organized to form functional tissues and organs. Cell atlas initiatives with single-cell RNA sequencing have begun to cha...
    Speaker: Jiang He
    Presented at: Genetics Week Virtual Event Series 2021
    1
    APR 20, 2021 | 12:00 AM
    Towards a Comprehensive Variation Benchmark for Medically-Relevant Autosomal Genes
    Towards a Comprehensive Variation Benchmark for Medically-Relevant...
    The Genome in a Bottle Consortium has published benchmarks for variant calling, but some challenging medically-relevant genes have been partially or fully excluded due to mapping challenges,...
    Speaker: Justin Wagner, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    1
    APR 20, 2021 | 12:00 AM
    Epigenetic Aging Studies in Mammals
    Epigenetic Aging Studies in Mammals
    In mammals, DNA methylation is an epigenetic mark that regulates gene expression by serving as a maintainable mark whose absence marks promoters and enhancers. Recent epidemiological studies...
    Speaker: Steve Horvath
    Presented at: Genetics Week Virtual Event Series 2021
    6
    APR 15, 2021 | 8:00 AM
    Human Pluripotent Stem Cells as a Model for Neurodevelopmental Toxicity
    Human Pluripotent Stem Cells as a Model for Neurodevelopmental...
    Date: April 15, 2021 Time: 8:00am PST Stem cell’s unique properties confer them a multitude of potential applications in the fields of cellular therapy, disease modelling and drug scre...
    Speaker: Cláudia Miranda
    Sponsored By: Thermo Fisher Scientific/Gibco
    4
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