Lysosomes are particular vesicles inside cells that digest enormous particles using hydrolytic chemicals. Lysosomes hold proteins that were made by the cell. The reason for the lysosome is to process things. Lysosomes are membrane bound, and help in the breakdown of old cell parts.
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Capturing membrane proteins in their native membrane nanodomain contexts Kallol Gupta, Ph.D. The intricate molecular environment of the native membrane profoundly influences every aspect of...
Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that i...
Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that closely mimic the complex structure and functionality of human organs. They offer more accurate...
Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that closely mimic the complex structure and functionality of human organs. They offer more accurate...
Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder with multiple motor and non-motor symptoms. PD is characterized by the presence on proteinaceous neuronal...
Autosomal dominant missense mutations that hyperactivate the LRRK2 protein kinase are a common cause of inherited Parkinson’s disease and therapeutic efficacy of LRRK2 inhibitors is be...